Literature DB >> 26996833

The Balancing Act of Ribonucleotides in DNA.

Susana M Cerritelli1, Robert J Crouch2.   

Abstract

The abundance of ribonucleotides in DNA remained undetected until recently because they are efficiently removed by the ribonucleotide excision repair (RER) pathway, a process similar to Okazaki fragment (OF) processing after incision by Ribonuclease H2 (RNase H2). All DNA polymerases incorporate ribonucleotides during DNA synthesis. How many, when, and why they are incorporated has been the focus of intense work during recent years by many labs. In this review, we discuss recent advances in ribonucleotide incorporation by eukaryotic DNA polymerases that suggest an evolutionarily conserved role for ribonucleotides in DNA. We also review the data that indicate that removal of ribonucleotides has an important role in maintaining genome stability. Published by Elsevier Ltd.

Entities:  

Keywords:  Aicardi–Goutières syndrome; DNA polymerase; RER; RNase H2; steric gate; systemic lupus erythematosus

Mesh：

Substances：

Year:  2016        PMID： 26996833      PMCID： PMC4851601          DOI： 10.1016/j.tibs.2016.02.005

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  84 in total

1.  Division of labor at the eukaryotic replication fork.

Authors:  Stephanie A Nick McElhinny; Dmitry A Gordenin; Carrie M Stith; Peter M J Burgers; Thomas A Kunkel
Journal:  Mol Cell       Date:  2008-04-25       Impact factor: 17.970

2.  Molecular insights into DNA polymerase deterrents for ribonucleotide insertion.

Authors:  Nisha A Cavanaugh; William A Beard; Vinod K Batra; Lalith Perera; Lee G Pedersen; Samuel H Wilson
Journal:  J Biol Chem       Date:  2011-07-06       Impact factor: 5.157

3.  Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts.

Authors:  Bjorn Rydberg; John Game
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-10       Impact factor: 11.205

4.  Ribonucleotide incorporation by yeast DNA polymerase ζ.

Authors:  Alena V Makarova; Stephanie A Nick McElhinny; Brian E Watts; Thomas A Kunkel; Peter M Burgers
Journal:  DNA Repair (Amst)       Date:  2014-03-24

5.  In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta.

Authors:  Y I Pavlov; P V Shcherbakova; T A Kunkel
Journal:  Genetics       Date:  2001-09       Impact factor: 4.562

6.  RNase H2-initiated ribonucleotide excision repair.

Authors:  Justin L Sparks; Hyongi Chon; Susana M Cerritelli; Thomas A Kunkel; Erik Johansson; Robert J Crouch; Peter M Burgers
Journal:  Mol Cell       Date:  2012-08-02       Impact factor: 17.970

7.  Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity.

Authors:  Bjoern Hiller; Martin Achleitner; Silke Glage; Ronald Naumann; Rayk Behrendt; Axel Roers
Journal:  J Exp Med       Date:  2012-07-16       Impact factor: 14.307

8.  The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.

Authors:  Martin A M Reijns; Doryen Bubeck; Lucien C D Gibson; Stephen C Graham; George S Baillie; E Yvonne Jones; Andrew P Jackson
Journal:  J Biol Chem       Date:  2010-12-22       Impact factor: 5.157

Review 9.  Structure-function studies of DNA polymerase λ.

Authors:  Katarzyna Bebenek; Lars C Pedersen; Thomas A Kunkel
Journal:  Biochemistry       Date:  2014-04-23       Impact factor: 3.162

10.  RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA.

Authors:  Federico Lazzaro; Daniele Novarina; Flavio Amara; Danielle L Watt; Jana E Stone; Vincenzo Costanzo; Peter M Burgers; Thomas A Kunkel; Paolo Plevani; Marco Muzi-Falconi
Journal:  Mol Cell       Date:  2012-01-13       Impact factor: 17.970
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  31 in total

1.  Both R-loop removal and ribonucleotide excision repair activities of RNase H2 contribute substantially to chromosome stability.

Authors:  Deborah A Cornelio; Hailey N C Sedam; Jessica A Ferrarezi; Nadia M V Sampaio; Juan Lucas Argueso
Journal:  DNA Repair (Amst)       Date:  2017-02-20

Review 2.  RNase H2-RED carpets the path to eukaryotic RNase H2 functions.

Authors:  Susana M Cerritelli; Robert J Crouch
Journal:  DNA Repair (Amst)       Date:  2019-10-23

3.  Effects of neutral salts and pH on the activity and stability of human RNase H2.

Authors:  Misato Baba; Kenji Kojima; Rihoko Nakase; Shota Imai; Tomomi Yamasaki; Teisuke Takita; Robert J Crouch; Kiyoshi Yasukawa
Journal:  J Biochem       Date:  2017-09-01       Impact factor: 3.387

Review 4.  Genome instabilities arising from ribonucleotides in DNA.

Authors:  Hannah L Klein
Journal:  DNA Repair (Amst)       Date:  2017-06-09

5.  Mitochondrial DNA Damage: Prevalence, Biological Consequence, and Emerging Pathways.

Authors:  Linlin Zhao; Philip Sumberaz
Journal:  Chem Res Toxicol       Date:  2020-06-18       Impact factor: 3.739

Review 6.  Ribonucleotide discrimination by translesion synthesis DNA polymerases.

Authors:  Alexandra Vaisman; Roger Woodgate
Journal:  Crit Rev Biochem Mol Biol       Date:  2018-07-04       Impact factor: 8.250

7.  Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.

Authors:  Elisa Mentegari; Emmanuele Crespan; Laura Bavagnoli; Miroslava Kissova; Federica Bertoletti; Simone Sabbioneda; Ralph Imhof; Shana J Sturla; Arman Nilforoushan; Ulrich Hübscher; Barbara van Loon; Giovanni Maga
Journal:  Nucleic Acids Res       Date:  2017-03-17       Impact factor: 16.971

8.  Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.

Authors:  Shar-Yin N Huang; Jessica S Williams; Mercedes E Arana; Thomas A Kunkel; Yves Pommier
Journal:  EMBO J       Date:  2016-12-08       Impact factor: 11.598

9.  Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA.

Authors:  Matilde Clarissa Malfatti; Ghislaine Henneke; Sathya Balachander; Kyung Duk Koh; Gary Newnam; Ryo Uehara; Robert J Crouch; Francesca Storici; Gianluca Tell
Journal:  J Biol Chem       Date:  2019-07-12       Impact factor: 5.157

Review 10.  Ribonucleotide incorporation into DNA during DNA replication and its consequences.

Authors:  Zhi-Xiong Zhou; Jessica S Williams; Scott A Lujan; Thomas A Kunkel
Journal:  Crit Rev Biochem Mol Biol       Date:  2021-01-18       Impact factor: 8.250
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