Literature DB >> 26989767

Slowing down the Grand Touring Prototype speed of cancer cells.

Anna Bianchi-Smiraglia1, Mikhail A Nikiforov1.   

Abstract

Enzymes involved in de novo production of guanosine triphosphate (GTP) have been recently revealed as integral components of melanoma progression through modulation of the activity of small GTPases. Here, we discuss the biology and therapeutic implications of these findings.

Entities:  

Year:  2015        PMID： 26989767      PMCID： PMC4792095          DOI： 10.1080/23723556.2015.1052181

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

Authors:  Imanol Arozarena; Berta Sanchez-Laorden; Leisl Packer; Cristina Hidalgo-Carcedo; Robert Hayward; Amaya Viros; Erik Sahai; Richard Marais
Journal:  Cancer Cell       Date:  2011-01-06       Impact factor: 31.743

2.  Modulation of cell motility by spatial repositioning of enzymatic ATP/ADP exchange capacity.

Authors:  Remco van Horssen; Edwin Janssen; Wilma Peters; Loes van de Pasch; Mariska M Te Lindert; Michiel M T van Dommelen; Peter C Linssen; Timo L M Ten Hagen; Jack A M Fransen; Bé Wieringa
Journal:  J Biol Chem       Date:  2008-11-12       Impact factor: 5.157

3.  Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity.

Authors:  A Bianchi-Smiraglia; J A Wawrzyniak; A Bagati; E K Marvin; J Ackroyd; S Moparthy; W Bshara; E E Fink; C E Foley; G E Morozevich; A E Berman; D S Shewach; M A Nikiforov
Journal:  Cell Death Differ       Date:  2015-04-24       Impact factor: 15.828

4.  Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid.

Authors:  Sophie Domhan; Stefan Muschal; Christian Schwager; Christian Morath; Ute Wirkner; Wilhelm Ansorge; Christian Maercker; Martin Zeier; Peter E Huber; Amir Abdollahi
Journal:  Mol Cancer Ther       Date:  2008-06       Impact factor: 6.261

5.  Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence.

Authors:  Sudha Mannava; Kalyana C Moparthy; Linda J Wheeler; Venkatesh Natarajan; Shoshanna N Zucker; Emily E Fink; Michael Im; Sheryl Flanagan; William C Burhans; Nathalie C Zeitouni; Donna S Shewach; Christopher K Mathews; Mikhail A Nikiforov
Journal:  Am J Pathol       Date:  2012-12-12       Impact factor: 4.307

6.  Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.

Authors:  Sudha Mannava; Vladimir Grachtchouk; Linda J Wheeler; Michael Im; Dazhong Zhuang; Elena G Slavina; Christopher K Mathews; Donna S Shewach; Mikhail A Nikiforov
Journal:  Cell Cycle       Date:  2008-06-03       Impact factor: 4.534

7.  A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.

Authors:  Joseph A Wawrzyniak; Anna Bianchi-Smiraglia; Wiam Bshara; Sudha Mannava; Jeff Ackroyd; Archis Bagati; Angela R Omilian; Michael Im; Natalia Fedtsova; Jeffrey C Miecznikowski; Kalyana C Moparthy; Shoshanna N Zucker; Qianqian Zhu; Nadezhda I Kozlova; Albert E Berman; Keith S Hoek; Andrei V Gudkov; Donna S Shewach; Carl D Morrison; Mikhail A Nikiforov
Journal:  Cell Rep       Date:  2013-10-17       Impact factor: 9.423

8.  Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators.

Authors:  Hiromi Imamura; Kim P Huynh Nhat; Hiroko Togawa; Kenta Saito; Ryota Iino; Yasuyuki Kato-Yamada; Takeharu Nagai; Hiroyuki Noji
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-31       Impact factor: 11.205

9.  Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.

Authors:  Sudha Mannava; Kalyana C Moparthy; Linda J Wheeler; Katerina I Leonova; Joseph A Wawrzyniak; Anna Bianchi-Smiraglia; Albert E Berman; Sheryl Flanagan; Donna S Shewach; Nathalie C Zeitouni; Andrei V Gudkov; Christopher K Mathews; Mikhail A Nikiforov
Journal:  Aging (Albany NY)       Date:  2012-12       Impact factor: 5.682

10.  Mycophenolic acid inhibits migration and invasion of gastric cancer cells via multiple molecular pathways.

Authors:  Boying Dun; Ashok Sharma; Yong Teng; Haitao Liu; Sharad Purohit; Heng Xu; Lingwen Zeng; Jin-Xiong She
Journal:  PLoS One       Date:  2013-11-15       Impact factor: 3.240
  10 in total
  1 in total

1.  Viagra releases the brakes on melanoma growth.

Authors:  Robert Feil
Journal:  Mol Cell Oncol       Date:  2016-05-31
  1 in total

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