Literature DB >> 29057299

Viagra releases the brakes on melanoma growth.

Robert Feil1.   

Abstract

Use of the phosphodiesterase 5 (PDE5) blocker sildenafil (Viagra) has been linked to an increased risk of melanoma. In a recent study we discovered a growth-promoting cGMP pathway in melanoma cells. cGMP degradation via PDE5 acts as a brake on this pathway. Inhibition of PDE5 releases this brake, providing a mechanism for the promelanoma effects of sildenafil.

Entities:  

Keywords:  CNP; Cancer; GTP; PKG; cGK; cyclic nucleotide; guanylate cyclase; phosphodiesterase inhibitor; tumor growth

Year:  2016        PMID： 29057299      PMCID： PMC5644484          DOI： 10.1080/23723556.2016.1188874

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

Authors:  Imanol Arozarena; Berta Sanchez-Laorden; Leisl Packer; Cristina Hidalgo-Carcedo; Robert Hayward; Amaya Viros; Erik Sahai; Richard Marais
Journal:  Cancer Cell       Date:  2011-01-06       Impact factor: 31.743

2.  Associations Do Not Equal Causation: Clinical Relevance of Statistical Associations of Phosphodiesterase Type 5 Inhibitors with Prostate Cancer Progression and Melanoma.

Authors:  Stacy Loeb; Thorsten Schlomm; Pär Stattin
Journal:  Eur Urol       Date:  2015-07-31       Impact factor: 20.096

3.  Transgenic mice for cGMP imaging.

Authors:  Martin Thunemann; Lai Wen; Matthias Hillenbrand; Angelos Vachaviolos; Susanne Feil; Thomas Ott; Xiaoxing Han; Dai Fukumura; Rakesh K Jain; Michael Russwurm; Cor de Wit; Robert Feil
Journal:  Circ Res       Date:  2013-06-25       Impact factor: 17.367

4.  Use of Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction and Risk of Malignant Melanoma.

Authors:  Stacy Loeb; Yasin Folkvaljon; Mats Lambe; David Robinson; Hans Garmo; Christian Ingvar; Pär Stattin
Journal:  JAMA       Date:  2015 Jun 23-30       Impact factor: 56.272

5.  Slowing down the Grand Touring Prototype speed of cancer cells.

Authors:  Anna Bianchi-Smiraglia; Mikhail A Nikiforov
Journal:  Mol Cell Oncol       Date:  2015-06-10

6.  Sildenafil use and increased risk of incident melanoma in US men: a prospective cohort study.

Authors:  Wen-Qing Li; Abrar A Qureshi; Kathleen C Robinson; Jiali Han
Journal:  JAMA Intern Med       Date:  2014-06       Impact factor: 21.873

7.  Melanoma, Viagra, and PDE5 Inhibitors: Proliferation and Metastasis.

Authors:  Miles D Houslay
Journal:  Trends Cancer       Date:  2016-03-17

8.  A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.

Authors:  Wiebke Wolfsgruber; Susanne Feil; Sabine Brummer; Oliver Kuppinger; Franz Hofmann; Robert Feil
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

9.  Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth.

Authors:  Sandeep Dhayade; Susanne Kaesler; Tobias Sinnberg; Hyazinth Dobrowinski; Stefanie Peters; Ulrike Naumann; He Liu; Robert E Hunger; Martin Thunemann; Tilo Biedermann; Birgit Schittek; Hans-Uwe Simon; Susanne Feil; Robert Feil
Journal:  Cell Rep       Date:  2016-03-10       Impact factor: 9.423

10.  Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function.

Authors:  Paolo Serafini; Kristen Meckel; Michael Kelso; Kimberly Noonan; Joseph Califano; Wayne Koch; Luigi Dolcetti; Vincenzo Bronte; Ivan Borrello
Journal:  J Exp Med       Date:  2006-11-13       Impact factor: 14.307
  10 in total
  3 in total

Review 1.  cGMP Signaling and Vascular Smooth Muscle Cell Plasticity.

Authors:  Moritz Lehners; Hyazinth Dobrowinski; Susanne Feil; Robert Feil
Journal:  J Cardiovasc Dev Dis       Date:  2018-04-19

2.  No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma.

Authors:  Jenny Z Wang; Stephanie Le; Claire Alexanian; Sucharita Boddu; Alexander Merleev; Alina Marusina; Emanual Maverakis
Journal:  World J Mens Health       Date:  2018-10-10       Impact factor: 5.400

Review 3.  Guanylyl Cyclase-cGMP Signaling Pathway in Melanocytes: Differential Effects of Altered Gravity in Non-Metastatic and Metastatic Cells.

Authors:  Krassimira Ivanova; Ruth Hemmersbach
Journal:  Int J Mol Sci       Date:  2020-02-08       Impact factor: 5.923
  3 in total

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