| Literature DB >> 26969274 |
Kazuyo Yasuda1, Yoshihiko Hirohashi2, Takafumi Kuroda3, Akari Takaya1, Terufumi Kubo1, Takayuki Kanaseki1, Tomohide Tsukahara1, Tadashi Hasegawa4, Tsuyoshi Saito3, Noriyuki Sato1, Toshihiko Torigoe5.
Abstract
Cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) are defined as small subpopulation of cancer cells that are endowed with higher tumor-initiating ability. CSCs/CICs are resistant to standard cancer therapies including chemotherapy and radiotherapy, and they are thus thought to be responsible for cancer recurrence and metastasis. Therefore, elucidation of molecular mechanisms of CSCs/CICs is essential to cure cancer. In this study, we analyzed the gene expression profiles of gynecological CSCs/CICs isolated as aldehyde dehydrogenase high (ALDH(high)) cells, and found that MAPK13, PTTG1IP, CAPN1 and UBQLN2 were preferentially expressed in CSCs/CICs. MAPK13 is expressed in uterine, ovary, stomach, colon, liver and kidney cancer tissues at higher levels compared with adjacent normal tissues. MAPK13 gene knockdown using siRNA reduced the ALDH(high) population and abrogated the tumor-initiating ability. These results indicate that MAPK13 is expressed in gynecological CSCs/CICs and has roles in the maintenance of CSCs/CICs and tumor-initiating ability, and MAPK13 might be a novel molecular target for treatment-resistant CSCs/CICs.Entities:
Keywords: Cancer stem cell; Gynecologic cancer; MAPK13; Tumor-initiation
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Year: 2016 PMID： 26969274 DOI： 10.1016/j.bbrc.2016.03.004
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575