Literature DB >> 2695083

What is the role of the cys-his motif in retroviral nucleocapsid (NC) proteins?

R A Katz, J E Jentoft.   

Abstract

Retroviruses encode a small, basic nucleocapsid (NC) protein that is found complexed to genomic RNA within the viral particle. The NC protein appears to function not only in a histone-like manner in packaging the RNA into the particle but also in specifically selecting the viral genomic RNA for packaging. A cysteine-histidine (cys-his) region, usually composed of 14 amino acids and reminiscent of the 'zinc fingers' of transcription factors, is the only highly conserved sequence element among the retroviral NC proteins. This review discusses the biochemical properties of NC, and its possible role(s) in retroviral replication. We also speculate on how the biochemical properties may relate to its function in RNA recognition and packaging.

Entities:  

Mesh:

Substances:

Year:  1989        PMID: 2695083     DOI: 10.1002/bies.950110605

Source DB:  PubMed          Journal:  Bioessays        ISSN: 0265-9247            Impact factor:   4.345


  16 in total

1.  FARE, a new family of foldback transposons in Arabidopsis.

Authors:  A J Windsor; C S Waddell
Journal:  Genetics       Date:  2000-12       Impact factor: 4.562

2.  Comparative analysis of protein domain organization.

Authors:  Yuzhen Ye; Adam Godzik
Journal:  Genome Res       Date:  2004-03       Impact factor: 9.043

3.  Terminal region recognition factor 1, a DNA-binding protein recognizing the inverted terminal repeats of the pGKl linear DNA plasmids.

Authors:  D G McNeel; F Tamanoi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

4.  Functional and physical interaction between the yeast splicing factors Slu7 and Prp18.

Authors:  X Zhang; B Schwer
Journal:  Nucleic Acids Res       Date:  1997-06-01       Impact factor: 16.971

5.  Sequence analysis of a cDNA containing the gag and prot regions of the soybean retrovirus-like element, SIRE-1.

Authors:  Y A Bi; H M Laten
Journal:  Plant Mol Biol       Date:  1996-03       Impact factor: 4.076

6.  Point mutations in the proximal Cys-His box of Rous sarcoma virus nucleocapsid protein.

Authors:  P Dupraz; S Oertle; C Meric; P Damay; P F Spahr
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

7.  Redox potential regulates binding of universal minicircle sequence binding protein at the kinetoplast DNA replication origin.

Authors:  Itay Onn; Neta Milman-Shtepel; Joseph Shlomai
Journal:  Eukaryot Cell       Date:  2004-04

8.  Effect of rearrangements and duplications of the Cys-His motifs of Rous sarcoma virus nucleocapsid protein.

Authors:  N E Bowles; P Damay; P F Spahr
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103

9.  Tightly bound zinc in human immunodeficiency virus type 1, human T-cell leukemia virus type I, and other retroviruses.

Authors:  J W Bess; P J Powell; H J Issaq; L J Schumack; M K Grimes; L E Henderson; L O Arthur
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

10.  Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1.

Authors:  M F Summers; L E Henderson; M R Chance; J W Bess; T L South; P R Blake; I Sagi; G Perez-Alvarado; R C Sowder; D R Hare
Journal:  Protein Sci       Date:  1992-05       Impact factor: 6.725

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.