Literature DB >> 26948981

Hormetic and anti-inflammatory properties of oxidized phospholipids.

Christina Mauerhofer1, Maria Philippova2, Olga V Oskolkova1, Valery N Bochkov3.   

Abstract

Oxidized phospholipids are generally recognized as deleterious factors involved in disease pathogenesis. This review summarizes the data suggesting that under certain biological conditions the opposite is correct, namely that OxPLs can also induce protective effects. Examples that are discussed in the review include upregulation of antioxidant genes, inhibition of inflammatory signaling pathways through Nrf2-dependent and -independent mechanisms, antagonism of Toll-like receptors, immuno-modulating and immuno-suppressive action of OxPLs in adaptive immunity and autoimmune disease, activation of PPARs known for their anti-inflammatory action, as well as protective action against lung edema in acute lung inflammation. The data support the notion that oxidation of phospholipids provides a negative feedback preventing damage to host tissues due to uncontrolled inflammation and oxidative stress.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Hormesis; Immuno-modulation; Inflammation; Lung barrier; PPAR; TLR

Mesh：

Substances：

Year:  2016        PMID： 26948981     DOI： 10.1016/j.mam.2016.02.003

Source DB:  PubMed          Journal:  Mol Aspects Med        ISSN： 0098-2997


  11 in total

Review 1.  The effect of oxidized phospholipids on phenotypic polarization and function of macrophages.

Authors:  Vlad Serbulea; Dory DeWeese; Norbert Leitinger
Journal:  Free Radic Biol Med       Date:  2017-02-21       Impact factor: 7.376

Review 2.  European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Authors:  Javier Egea; Isabel Fabregat; Yves M Frapart; Pietro Ghezzi; Agnes Görlach; Thomas Kietzmann; Kateryna Kubaichuk; Ulla G Knaus; Manuela G Lopez; Gloria Olaso-Gonzalez; Andreas Petry; Rainer Schulz; Jose Vina; Paul Winyard; Kahina Abbas; Opeyemi S Ademowo; Catarina B Afonso; Ioanna Andreadou; Haike Antelmann; Fernando Antunes; Mutay Aslan; Markus M Bachschmid; Rui M Barbosa; Vsevolod Belousov; Carsten Berndt; David Bernlohr; Esther Bertrán; Alberto Bindoli; Serge P Bottari; Paula M Brito; Guia Carrara; Ana I Casas; Afroditi Chatzi; Niki Chondrogianni; Marcus Conrad; Marcus S Cooke; João G Costa; Antonio Cuadrado; Pham My-Chan Dang; Barbara De Smet; Bilge Debelec-Butuner; Irundika H K Dias; Joe Dan Dunn; Amanda J Edson; Mariam El Assar; Jamel El-Benna; Péter Ferdinandy; Ana S Fernandes; Kari E Fladmark; Ulrich Förstermann; Rashid Giniatullin; Zoltán Giricz; Anikó Görbe; Helen Griffiths; Vaclav Hampl; Alina Hanf; Jan Herget; Pablo Hernansanz-Agustín; Melanie Hillion; Jingjing Huang; Serap Ilikay; Pidder Jansen-Dürr; Vincent Jaquet; Jaap A Joles; Balaraman Kalyanaraman; Danylo Kaminskyy; Mahsa Karbaschi; Marina Kleanthous; Lars-Oliver Klotz; Bato Korac; Kemal Sami Korkmaz; Rafal Koziel; Damir Kračun; Karl-Heinz Krause; Vladimír Křen; Thomas Krieg; João Laranjinha; Antigone Lazou; Huige Li; Antonio Martínez-Ruiz; Reiko Matsui; Gethin J McBean; Stuart P Meredith; Joris Messens; Verónica Miguel; Yuliya Mikhed; Irina Milisav; Lidija Milković; Antonio Miranda-Vizuete; Miloš Mojović; María Monsalve; Pierre-Alexis Mouthuy; John Mulvey; Thomas Münzel; Vladimir Muzykantov; Isabel T N Nguyen; Matthias Oelze; Nuno G Oliveira; Carlos M Palmeira; Nikoletta Papaevgeniou; Aleksandra Pavićević; Brandán Pedre; Fabienne Peyrot; Marios Phylactides; Gratiela G Pircalabioru; Andrew R Pitt; Henrik E Poulsen; Ignacio Prieto; Maria Pia Rigobello; Natalia Robledinos-Antón; Leocadio Rodríguez-Mañas; Anabela P Rolo; Francis Rousset; Tatjana Ruskovska; Nuno Saraiva; Shlomo Sasson; Katrin Schröder; Khrystyna Semen; Tamara Seredenina; Anastasia Shakirzyanova; Geoffrey L Smith; Thierry Soldati; Bebiana C Sousa; Corinne M Spickett; Ana Stancic; Marie José Stasia; Holger Steinbrenner; Višnja Stepanić; Sebastian Steven; Kostas Tokatlidis; Erkan Tuncay; Belma Turan; Fulvio Ursini; Jan Vacek; Olga Vajnerova; Kateřina Valentová; Frank Van Breusegem; Lokman Varisli; Elizabeth A Veal; A Suha Yalçın; Olha Yelisyeyeva; Neven Žarković; Martina Zatloukalová; Jacek Zielonka; Rhian M Touyz; Andreas Papapetropoulos; Tilman Grune; Santiago Lamas; Harald H H W Schmidt; Fabio Di Lisa; Andreas Daiber
Journal:  Redox Biol       Date:  2017-05-18       Impact factor: 11.799

Review 3.  Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins.

Authors:  Jenny Schröter; Jürgen Schiller
Journal:  Oxid Med Cell Longev       Date:  2016-12-20       Impact factor: 6.543

Review 4.  Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

Authors:  O S Ademowo; H K I Dias; D G A Burton; H R Griffiths
Journal:  Biogerontology       Date:  2017-05-24       Impact factor: 4.277

Review 5.  Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives.

Authors:  Ronan Lordan; Alexandros Tsoupras; Ioannis Zabetakis; Constantinos A Demopoulos
Journal:  Molecules       Date:  2019-12-03       Impact factor: 4.411

6.  Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.

Authors:  Vlad Serbulea; Clint M Upchurch; Katelyn W Ahern; Gael Bories; Paxton Voigt; Dory E DeWeese; Akshaya K Meher; Thurl E Harris; Norbert Leitinger
Journal:  Mol Metab       Date:  2017-11-07       Impact factor: 7.422

7.  Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms.

Authors:  Taras Afonyushkin; Olga V Oskolkova; Valery N Bochkov
Journal:  Angiogenesis       Date:  2018-01-12       Impact factor: 9.596

8.  The complex association between the antioxidant defense system and clinical status in early psychosis.

Authors:  Saínza García; Susana Alberich; Mónica Martínez-Cengotitabengoa; Celso Arango; Josefina Castro-Fornieles; Mara Parellada; Inmaculada Baeza; Carmen Moreno; Juan Antonio Micó; Esther Berrocoso; Montserrat Graell; Soraya Otero; Tatiana Simal; Ana González-Pinto
Journal:  PLoS One       Date:  2018-04-26       Impact factor: 3.240

9.  Role for Lipids Secreted by Irradiated Peripheral Blood Mononuclear Cells in Inflammatory Resolution in Vitro.

Authors:  Layla Panahipour; Evgeniya Kochergina; Maria Laggner; Matthias Zimmermann; Michael Mildner; Hendrik J Ankersmit; Reinhard Gruber
Journal:  Int J Mol Sci       Date:  2020-06-30       Impact factor: 6.208

Review 10.  Innate sensing of oxidation-specific epitopes in health and disease.

Authors:  Christoph J Binder; Nikolina Papac-Milicevic; Joseph L Witztum
Journal:  Nat Rev Immunol       Date:  2016-06-27       Impact factor: 53.106
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