Oxidized phospholipids are products of lipid oxidation that are found on oxidized low-density lipoproteins and apoptotic cell membranes. These biologically active lipids were shown to affect a variety of cell types and attributed pro-as well as anti-inflammatory effects. In particular, macrophages exposed to oxidized phospholipids drastically change their gene expression pattern and function. These 'Mox,'macrophages were identified in atherosclerotic lesions, however, it remains unclear how lipid oxidation products are sensed by macrophages and how they influence their biological function. Here, we review recent developments in the field that provide insight into the structure, recognition, and downstream signaling of oxidized phospholipids in macrophages.
Oxidized n class="Chemical">phospholipids are products of lipid oxidation that are found on oxidized low-density lipoproteins and apoptotic cell membranes. These biologically active lipids were shown to affect a variety of cell types and attributed pro-as well as anti-inflammatory effects. In particular, macrophages exposed to oxidized phospholipids drastically change their gene expression pattern and function. These 'Mox,'macrophages were identified in atherosclerotic lesions, however, it remains unclear how lipid oxidation products are sensed by macrophages and how they influence their biological function. Here, we review recent developments in the field that provide insight into the structure, recognition, and downstream signaling of oxidized phospholipids in macrophages.
Authors: Stefan Blüml; Stefanie Kirchberger; Valery N Bochkov; Gerhard Krönke; Karl Stuhlmeier; Otto Majdic; Gerhard J Zlabinger; Walter Knapp; Bernd R Binder; Johannes Stöckl; Norbert Leitinger Journal: J Immunol Date: 2005-07-01 Impact factor: 5.422
Authors: Aaron V Pontsler; Andy St Hilaire; Gopal K Marathe; Guy A Zimmerman; Thomas M McIntyre Journal: J Biol Chem Date: 2002-01-23 Impact factor: 5.157
Authors: Soumya Panigrahi; Yi Ma; Li Hong; Detao Gao; Xiaoxia Z West; Robert G Salomon; Tatiana V Byzova; Eugene A Podrez Journal: Circ Res Date: 2012-10-15 Impact factor: 17.367
Authors: A D Watson; M Navab; S Y Hama; A Sevanian; S M Prescott; D M Stafforini; T M McIntyre; B N Du; A M Fogelman; J A Berliner Journal: J Clin Invest Date: 1995-02 Impact factor: 14.808
Authors: Olga V Oskolkova; Taras Afonyushkin; Beatrix Preinerstorfer; Wolfgang Bicker; Elena von Schlieffen; Eva Hainzl; Svitlana Demyanets; Gernot Schabbauer; Wolfgang Lindner; Alexandros D Tselepis; Johann Wojta; Bernd R Binder; Valery N Bochkov Journal: J Immunol Date: 2010-11-10 Impact factor: 5.422
Authors: Lukas Haider; Marie T Fischer; Josa M Frischer; Jan Bauer; Romana Höftberger; Gergö Botond; Harald Esterbauer; Christoph J Binder; Joseph L Witztum; Hans Lassmann Journal: Brain Date: 2011-06-07 Impact factor: 13.501
Authors: Steven J Forrester; Daniel S Kikuchi; Marina S Hernandes; Qian Xu; Kathy K Griendling Journal: Circ Res Date: 2018-03-16 Impact factor: 17.367
Authors: Yulia Y Tyurina; Claudette M St Croix; Simon C Watkins; Alan M Watson; Michael W Epperly; Tamil S Anthonymuthu; Elena R Kisin; Irina I Vlasova; Olga Krysko; Dmitri V Krysko; Alexandr A Kapralov; Haider H Dar; Vladimir A Tyurin; Andrew A Amoscato; Elena N Popova; Sergey B Bolevich; Peter S Timashev; John A Kellum; Sally E Wenzel; Rama K Mallampalli; Joel S Greenberger; Hulya Bayir; Anna A Shvedova; Valerian E Kagan Journal: J Leukoc Biol Date: 2019-05-09 Impact factor: 4.962