Literature DB >> 26942071

Radiotherapy supports tumor-specific immunity by acute inflammation.

Laura Surace1, Nicole Angelika Scheifinger1, Anurag Gupta1, Maries van den Broek1.   

Abstract

Local immune stimulation is an integral part of radiotherapy. Production of anaphylatoxins is a crucial initial event in radiotherapy-induced immunity and clinical efficacy. We propose applying radiotherapy in few fractions and include radiation holidays to achieve acute rather than chronic inflammatory responses, which promote protective immunity and therapeutic efficacy.

Entities:  

Keywords:  cancer; immune response; inflammation; radiotherapy

Year:  2015        PMID： 26942071      PMCID： PMC4760297          DOI： 10.1080/2162402X.2015.1060391

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Complement-dependent modulation of antitumor immunity following radiation therapy.

Authors:  Michelle Elvington; Melissa Scheiber; Xiaofeng Yang; Katherine Lyons; Dustin Jacqmin; Casey Wadsworth; David Marshall; Kenneth Vanek; Stephen Tomlinson
Journal:  Cell Rep       Date:  2014-07-24       Impact factor: 9.423

2.  Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial.

Authors:  Jayant S Vaidya; David J Joseph; Jeffrey S Tobias; Max Bulsara; Frederik Wenz; Christobel Saunders; Michael Alvarado; Henrik L Flyger; Samuele Massarut; Wolfgang Eiermann; Mohammed Keshtgar; John Dewar; Uta Kraus-Tiefenbacher; Marc Sütterlin; Laura Esserman; Helle M R Holtveg; Mario Roncadin; Steffi Pigorsch; Marinos Metaxas; Mary Falzon; April Matthews; Tammy Corica; Norman R Williams; Michael Baum
Journal:  Lancet       Date:  2010-07-10       Impact factor: 79.321

3.  Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation.

Authors:  Anurag Gupta; Hans Christian Probst; Van Vuong; Alexandro Landshammer; Sabine Muth; Hideo Yagita; Reto Schwendener; Martin Pruschy; Alexander Knuth; Maries van den Broek
Journal:  J Immunol       Date:  2012-06-08       Impact factor: 5.422

4.  Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response.

Authors:  Laura Surace; Veronika Lysenko; Andrea Orlando Fontana; Virginia Cecconi; Hans Janssen; Antonela Bicvic; Michal Okoniewski; Martin Pruschy; Reinhard Dummer; Jacques Neefjes; Alexander Knuth; Anurag Gupta; Maries van den Broek
Journal:  Immunity       Date:  2015-04-14       Impact factor: 31.745

Review 5.  Innate and adaptive immune cells in the tumor microenvironment.

Authors:  Thomas F Gajewski; Hans Schreiber; Yang-Xin Fu
Journal:  Nat Immunol       Date:  2013-10       Impact factor: 25.606

6.  Radiotherapy of human sarcoma promotes an intratumoral immune effector signature.

Authors:  Anu Sharma; Beata Bode; Gabriela Studer; Holger Moch; Michal Okoniewski; Alexander Knuth; Lotta von Boehmer; Maries van den Broek
Journal:  Clin Cancer Res       Date:  2013-07-16       Impact factor: 12.531

Review 7.  Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms.

Authors:  Eran Elinav; Roni Nowarski; Christoph A Thaiss; Bo Hu; Chengcheng Jin; Richard A Flavell
Journal:  Nat Rev Cancer       Date:  2013-11       Impact factor: 69.800

8.  Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.

Authors:  Christina Twyman-Saint Victor; Andrew J Rech; Amit Maity; Ramesh Rengan; Kristen E Pauken; Erietta Stelekati; Joseph L Benci; Bihui Xu; Hannah Dada; Pamela M Odorizzi; Ramin S Herati; Kathleen D Mansfield; Dana Patsch; Ravi K Amaravadi; Lynn M Schuchter; Hemant Ishwaran; Rosemarie Mick; Daniel A Pryma; Xiaowei Xu; Michael D Feldman; Tara C Gangadhar; Stephen M Hahn; E John Wherry; Robert H Vonderheide; Andy J Minn
Journal:  Nature       Date:  2015-03-09       Impact factor: 49.962

9.  Modulation of the antitumor immune response by complement.

Authors:  Maciej M Markiewski; Robert A DeAngelis; Fabian Benencia; Salome K Ricklin-Lichtsteiner; Anna Koutoulaki; Craig Gerard; George Coukos; John D Lambris
Journal:  Nat Immunol       Date:  2008-09-28       Impact factor: 25.606

10.  Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

Authors:  Michael G Strainic; Ethan M Shevach; Fengqi An; Feng Lin; M Edward Medof
Journal:  Nat Immunol       Date:  2012-12-23       Impact factor: 25.606
  10 in total
  3 in total

Review 1.  Current advances in immune checkpoint inhibitor combinations with radiation therapy or cryotherapy for breast cancer.

Authors:  Alice Y Ho; Shervin Tabrizi; Samantha A Dunn; Heather L McArthur
Journal:  Breast Cancer Res Treat       Date:  2021-10-29       Impact factor: 4.872

2.  Balance of pro- and anti-inflammatory cytokines in livers of high fat diet rats exposed to fractionated gamma irradiation.

Authors:  Ayman Khalil; Hasan Omran; Fatima Alsheikh
Journal:  BMC Res Notes       Date:  2018-10-19

Review 3.  Improving radiotherapy in cancer treatment: Promises and challenges.

Authors:  Helen H W Chen; Macus Tien Kuo
Journal:  Oncotarget       Date:  2017-06-08
  3 in total

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