Tiffany L Blake-Lamb1, Lindsey M Locks2, Meghan E Perkins3, Jennifer A Woo Baidal4, Erika R Cheng3, Elsie M Taveras5. 1. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts; Kraft Center for Community Health Leadership, Partners Healthcare, Boston, Massachusetts. 2. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 3. Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts. 4. Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts;; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Medical Center, New York City, New York. 5. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts;. Electronic address: elsie.taveras@mgh.harvard.edu.
Abstract
CONTEXT: The "first 1,000 days"-conception through age 24 months-are critical for the development and prevention of childhood obesity. This study systematically reviews existing and ongoing interventions during this period, identifies gaps in current research, and discusses conceptual frameworks and opportunities for future interventions. EVIDENCE ACQUISITION: PubMed, Embase, Web of Science, and ClinicalTrials.gov were searched to identify completed and ongoing interventions implemented during pregnancy through age 24 months that aimed to prevent overweight/obesity between ages 6 months and 18 years. English-language, controlled interventions published between January 1, 1980 and December 12, 2014, were analyzed between December 13, 2014 and March 15, 2015. EVIDENCE SYNTHESIS: Of 34 completed studies from 26 unique identified interventions, nine were effective. Effective interventions focused on individual- or family-level behavior changes through home visits, individual counseling or group sessions in clinical settings, a combination of home and group visits in a community setting, and using hydrolyzed protein formula. Protein-enriched formula increased childhood obesity risk. Forty-seven ongoing interventions were identified. Across completed and ongoing interventions, the majority target individual- or family-level changes, many are conducted in clinical settings, and few target early-life systems and policies that may impact childhood obesity. CONCLUSIONS: Obesity interventions may have the greatest preventive effect if begun early in life. Yet, few effective interventions in the first 1,000 days exist, and many target individual-level behaviors of parents and infants. Interventions that operate at systems levels and are grounded in salient conceptual frameworks hold promise for improving future models of early-life obesity prevention.
CONTEXT: The "first 1,000 days"-conception through age 24 months-are critical for the development and prevention of childhood obesity. This study systematically reviews existing and ongoing interventions during this period, identifies gaps in current research, and discusses conceptual frameworks and opportunities for future interventions. EVIDENCE ACQUISITION: PubMed, Embase, Web of Science, and ClinicalTrials.gov were searched to identify completed and ongoing interventions implemented during pregnancy through age 24 months that aimed to prevent overweight/obesity between ages 6 months and 18 years. English-language, controlled interventions published between January 1, 1980 and December 12, 2014, were analyzed between December 13, 2014 and March 15, 2015. EVIDENCE SYNTHESIS: Of 34 completed studies from 26 unique identified interventions, nine were effective. Effective interventions focused on individual- or family-level behavior changes through home visits, individual counseling or group sessions in clinical settings, a combination of home and group visits in a community setting, and using hydrolyzed protein formula. Protein-enriched formula increased childhood obesity risk. Forty-seven ongoing interventions were identified. Across completed and ongoing interventions, the majority target individual- or family-level changes, many are conducted in clinical settings, and few target early-life systems and policies that may impact childhood obesity. CONCLUSIONS:Obesity interventions may have the greatest preventive effect if begun early in life. Yet, few effective interventions in the first 1,000 days exist, and many target individual-level behaviors of parents and infants. Interventions that operate at systems levels and are grounded in salient conceptual frameworks hold promise for improving future models of early-life obesity prevention.
Authors: Gina M French; Lisa Nicholson; Theresa Skybo; Elizabeth G Klein; Patricia M Schwirian; Lisa Murray-Johnson; Amy Sternstein; Ihuoma Eneli; Beth Boettner; Judith A Groner Journal: Pediatrics Date: 2012-08-13 Impact factor: 7.124
Authors: Philip J Ciampa; Disha Kumar; Shari L Barkin; Lee M Sanders; H Shonna Yin; Eliana M Perrin; Russell L Rothman Journal: Arch Pediatr Adolesc Med Date: 2010-12
Authors: M Hakanen; H Lagström; T Kaitosaari; H Niinikoski; K Näntö-Salonen; E Jokinen; L Sillanmäki; J Viikari; T Rönnemaa; O Simell Journal: Int J Obes (Lond) Date: 2006-04 Impact factor: 5.095
Authors: Matthew W Gillman; Sheryl L Rifas-Shiman; Ken Kleinman; Emily Oken; Janet W Rich-Edwards; Elsie M Taveras Journal: Obesity (Silver Spring) Date: 2008-05-01 Impact factor: 5.002
Authors: Matthew W Gillman; Helena Oakey; Peter A Baghurst; Robert E Volkmer; Jeffrey S Robinson; Caroline A Crowther Journal: Diabetes Care Date: 2010-02-11 Impact factor: 19.112
Authors: Robert M Siegel; Matthew Haemer; Roohi Y Kharofa; Amy L Christison; Sarah E Hampl; Lydia Tinajero-Deck; Mary Kate Lockhart; Sarah Reich; Stephen J Pont; William Stratbucker; Thomas N Robinson; Laura A Shaffer; Susan J Woolford Journal: Child Obes Date: 2018-06-07 Impact factor: 2.992
Authors: Sani M Roy; David A Fields; Jonathan A Mitchell; Colin P Hawkes; Andrea Kelly; Gary D Wu; Patricia A DeRusso; Michal A Elovitz; Eileen Ford; Danielle Drigo; Babette S Zemel; Shana E McCormack Journal: J Pediatr Date: 2018-09-26 Impact factor: 4.406
Authors: Dina H Griauzde; Edith C Kieffer; Sarah E Domoff; Kristen Hess; Susannah Feinstein; Amy Frank; Denise Pike; Megan H Pesch Journal: Eat Behav Date: 2019-12-24
Authors: I M Aris; J Y Bernard; L-W Chen; M T Tint; W W Pang; S E Soh; S-M Saw; L P-C Shek; K M Godfrey; P D Gluckman; Y-S Chong; F Yap; M S Kramer; Y S Lee Journal: Int J Obes (Lond) Date: 2017-07-28 Impact factor: 5.095