Jian Zhao1, Cen Wen2, Ming Li3. 1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, People's Republic of China. 2. Department of Anesthesiology, Affiliated Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China. 3. Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, People's Republic of China. limingsmmu@sina.cn.
Abstract
BACKGROUND: Recently, many institutions have investigated the associations of interleukin-17 (IL17) polymorphisms with tuberculosis (TB) susceptibility, while those results are inconsistent. The purpose of this meta-analysis is to comprehensively assess whether IL17A rs22275913, IL17F rs763780, and IL17A rs3748067 polymorphisms are correlated with TB risk. METHODS: Electronic bibliographic databases were searched for case-control studies which potentially focused on the relationship between the aforementioned polymorphisms and TB risk on October 15th, 2015. Pooled odds ratios (OR) combined with 95 % confidence intervals (CI) were employed to assess the associations. RESULTS: There was no significant association of IL-17A rs22275913 polymorphism with susceptibility to TB in Asians or Caucasians. For IL-17A rs3748067 polymorphism, significant associations were observed in Asian (T vs. C: OR 1.461, 95 % CI 1.158-1.844, P = 0.001; TT vs. CC: OR 1.871, 95 % CI 1.140-3.069, P = 0.013; TT/TC vs. CC: OR 1.392 95 % CI 1.062-1.825, P = 0.017; TT vs. TC/CC: OR 1.820, 95 % CI 1.111-2.981, P = 0.017). For IL-17F rs763780, we detected the significant associations under allele contrast, heterozygote, dominant and recessive models (C vs. T: OR 1.571, 95 % CI 1.352-1.824, P = 0.000; CT vs. TT: OR 1.624, 95 % CI 1.346-1.958, P = 0.000; CT/TT vs. TT: OR 1.639, 95 % CI 1.381-1.946, P = 0.000, respectively). The corresponding results were also detected in Asian populations (C vs. T: OR 1.068, 95 % CI 1.380-1.875, P = 0.000; CT vs. TT: OR 1.689, 95 % CI 1.390-2.053, P = 0.000; CT/TT vs. TT: OR 1.695, 95 % CI 1.420-2.023, P = 0.000), while there were no significant associations in Caucasian. CONCLUSION: IL-17F rs763780 allele C and IL-17A rs3748067 allele C may be involved in the susceptibility to TB in Asian populations. There were no significant associations between IL-17A rs22275913 polymorphism and risk of TB.
BACKGROUND: Recently, many institutions have investigated the associations of interleukin-17 (IL17) polymorphisms with tuberculosis (TB) susceptibility, while those results are inconsistent. The purpose of this meta-analysis is to comprehensively assess whether IL17Ars22275913, IL17Frs763780, and IL17Ars3748067 polymorphisms are correlated with TB risk. METHODS: Electronic bibliographic databases were searched for case-control studies which potentially focused on the relationship between the aforementioned polymorphisms and TB risk on October 15th, 2015. Pooled odds ratios (OR) combined with 95 % confidence intervals (CI) were employed to assess the associations. RESULTS: There was no significant association of IL-17Ars22275913 polymorphism with susceptibility to TB in Asians or Caucasians. For IL-17Ars3748067 polymorphism, significant associations were observed in Asian (T vs. C: OR 1.461, 95 % CI 1.158-1.844, P = 0.001; TT vs. CC: OR 1.871, 95 % CI 1.140-3.069, P = 0.013; TT/TC vs. CC: OR 1.392 95 % CI 1.062-1.825, P = 0.017; TT vs. TC/CC: OR 1.820, 95 % CI 1.111-2.981, P = 0.017). For IL-17Frs763780, we detected the significant associations under allele contrast, heterozygote, dominant and recessive models (C vs. T: OR 1.571, 95 % CI 1.352-1.824, P = 0.000; CT vs. TT: OR 1.624, 95 % CI 1.346-1.958, P = 0.000; CT/TT vs. TT: OR 1.639, 95 % CI 1.381-1.946, P = 0.000, respectively). The corresponding results were also detected in Asian populations (C vs. T: OR 1.068, 95 % CI 1.380-1.875, P = 0.000; CT vs. TT: OR 1.689, 95 % CI 1.390-2.053, P = 0.000; CT/TT vs. TT: OR 1.695, 95 % CI 1.420-2.023, P = 0.000), while there were no significant associations in Caucasian. CONCLUSION:IL-17Frs763780 allele C and IL-17Ars3748067 allele C may be involved in the susceptibility to TB in Asian populations. There were no significant associations between IL-17Ars22275913 polymorphism and risk of TB.
Authors: P Ye; P B Garvey; P Zhang; S Nelson; G Bagby; W R Summer; P Schwarzenberger; J E Shellito; J K Kolls Journal: Am J Respir Cell Mol Biol Date: 2001-09 Impact factor: 6.914
Authors: Mei Yu Peng; Zhao Hua Wang; Chun Yan Yao; Li Na Jiang; Qi Li Jin; Jing Wang; Bai Qing Li Journal: Cell Mol Immunol Date: 2008-06 Impact factor: 11.530
Authors: Javier Gonzalo Ocejo-Vinyals; Elena Puente de Mateo; María Ángeles Hoz; José Luis Arroyo; Ramón Agüero; Fernado Ausín; M Carmen Fariñas Journal: Cytokine Date: 2013-06-15 Impact factor: 3.861
Authors: Bruno Abarca Tomás; Christopher Pell; Aurora Bueno Cavanillas; José Guillén Solvas; Robert Pool; María Roura Journal: PLoS One Date: 2013-12-05 Impact factor: 3.240
Authors: Matti Korppi; Johanna Teräsjärvi; Milla Liehu-Martiskainen; Eero Lauhkonen; Juho Vuononvirta; Kirsi Nuolivirta; Liisa Kröger; Laura Pöyhönen; Minna K Karjalainen; Qiushui He Journal: Sci Rep Date: 2017-09-15 Impact factor: 4.379
Authors: Amanda J Martinot; Eryn Blass; Jingyou Yu; Malika Aid; Shant H Mahrokhian; Sara B Cohen; Courtney R Plumlee; Rafael A Larocca; Noman Siddiqi; Shoko Wakabayashi; Michelle Gardner; Rebecca Audette; Anne Devorak; Kevin B Urdahl; Eric J Rubin; Dan H Barouch Journal: PLoS Pathog Date: 2020-12-14 Impact factor: 6.823