PURPOSE: The HLA-DRB1 gene polymorphisms have been implicated in susceptibility to tuberculosis (TB). However, a large number of studies have reported inconclusive results. This study was conducted to investigate the relationship of HLA-DRB1 gene polymorphisms and TB risk by a meta-analysis. METHODS: A search was performed in Embase, PubMed, Wanfang Database, and China National Knowledge Internet (CNKI) up to Jul 30, 2014. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analyses were calculated by STATA 11.0 software. RESULTS: All 31 articles involving 3,416 cases and 4,515 controls were identified. The pooled results indicated a significant association between HLA-DRB1*04 (OR 1.22, 95% CI 1.00-1.48, P = 0.048), *09 (OR 1.50, 95% CI 1.08-2.08, P = 0.016), *10 (OR 1.23, 95% CI 1.01-1.49, P = 0.035), *11 (OR 0.72, 95% CI 0.53-0.99, P = 0.044), *15 (OR 1.40, 95% CI 1.14-1.73, P = 0.001), and *16 (OR 1.33, 95% CI 1.08-1.63, P = 0.007) gene polymorphisms and TB risk. In addition, the results also show no significant association between HLA-DRB1*01 (P = 0.748), *03 (P = 0.947), *07 (P = 0.966), *08 (P = 0.440), *12 (P = 0.288), *13 (P = 0.241), and *14 (P = 0.551) gene polymorphisms and TB risk. CONCLUSIONS: This study suggested that the HLA-DRB1*04, *09, *10, *15, and *16 gene polymorphisms may contribute to the risk of TB, especially in the East Asian. But the HLA-DRB1*11 gene polymorphism may be a protective factor for TB risk. Unfortunately, there is no significant association between the HLA-DRB1*01, *03, *07, *08, *12, *13, and *14 gene polymorphisms and TB risk.
PURPOSE: The HLA-DRB1 gene polymorphisms have been implicated in susceptibility to tuberculosis (TB). However, a large number of studies have reported inconclusive results. This study was conducted to investigate the relationship of HLA-DRB1 gene polymorphisms and TB risk by a meta-analysis. METHODS: A search was performed in Embase, PubMed, Wanfang Database, and China National Knowledge Internet (CNKI) up to Jul 30, 2014. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analyses were calculated by STATA 11.0 software. RESULTS: All 31 articles involving 3,416 cases and 4,515 controls were identified. The pooled results indicated a significant association between HLA-DRB1*04 (OR 1.22, 95% CI 1.00-1.48, P = 0.048), *09 (OR 1.50, 95% CI 1.08-2.08, P = 0.016), *10 (OR 1.23, 95% CI 1.01-1.49, P = 0.035), *11 (OR 0.72, 95% CI 0.53-0.99, P = 0.044), *15 (OR 1.40, 95% CI 1.14-1.73, P = 0.001), and *16 (OR 1.33, 95% CI 1.08-1.63, P = 0.007) gene polymorphisms and TB risk. In addition, the results also show no significant association between HLA-DRB1*01 (P = 0.748), *03 (P = 0.947), *07 (P = 0.966), *08 (P = 0.440), *12 (P = 0.288), *13 (P = 0.241), and *14 (P = 0.551) gene polymorphisms and TB risk. CONCLUSIONS: This study suggested that the HLA-DRB1*04, *09, *10, *15, and *16 gene polymorphisms may contribute to the risk of TB, especially in the East Asian. But the HLA-DRB1*11 gene polymorphism may be a protective factor for TB risk. Unfortunately, there is no significant association between the HLA-DRB1*01, *03, *07, *08, *12, *13, and *14 gene polymorphisms and TB risk.
Authors: R Duarte; C Carvalho; C Pereira; A Bettencourt; A Carvalho; M Villar; A Domingos; H Barros; Ja Marques; P Pinho Costa; D Mendonça; B Martins Journal: Rev Port Pneumol Date: 2011 Jan-Feb
Authors: Dolores López-Maderuelo; Francisco Arnalich; Rocio Serantes; Alicia González; Rosa Codoceo; Rosario Madero; Juan J Vázquez; Carmen Montiel Journal: Am J Respir Crit Care Med Date: 2003-01-16 Impact factor: 21.405
Authors: A Oliveira-Cortez; A C Melo; V E Chaves; A Condino-Neto; P Camargos Journal: Eur J Clin Microbiol Infect Dis Date: 2016-07-13 Impact factor: 3.267
Authors: Dhêmerson Souza de Lima; Mauricio Morishi Ogusku; Maisa Porto Dos Santos; Cláudia Maria de Melo Silva; Vanessa Alves de Almeida; Irineide Assumpção Antunes; Antonio Luiz Boechat; Rajendranath Ramasawmy; Aya Sadahiro Journal: PLoS One Date: 2016-02-22 Impact factor: 3.240
Authors: Xiang Tong; Yao Ma; Xundong Niu; Zhipeng Yan; Sitong Liu; Bo Peng; Shifeng Peng; Hong Fan Journal: Medicine (Baltimore) Date: 2016-07 Impact factor: 1.889