Literature DB >> 29151578

Th1 cytokines, true functional signatures for protective immunity against TB?

Gucheng Zeng1, Guoliang Zhang2, Xinchun Chen3.   

Abstract

The lack of an effective preventative vaccine against tuberculosis (TB) presents a great challenge to TB control. Since it takes an extremely long time to accurately determine the protective efficacy of TB vaccines, there is a great need to identify the surrogate signatures of protection to facilitate vaccine development. Unfortunately, antigen-specific Th1 cytokines that are currently used to evaluate the protective efficacy of the TB vaccine, do not align with the protection and failure of TB vaccine candidates in clinical trials. In this review, we discuss the limitation of current Th1 cytokines as surrogates of protection and address the potential elements that should be considered to finalize the true functional signatures of protective immunity against TB.

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Year:  2017        PMID： 29151578      PMCID： PMC5843617          DOI： 10.1038/cmi.2017.113

Source DB:  PubMed          Journal:  Cell Mol Immunol        ISSN： 1672-7681            Impact factor:   11.530


  122 in total

Review 1.  Latent Mycobacterium tuberculosis infection.

Authors:  Haileyesus Getahun; Alberto Matteelli; Richard E Chaisson; Mario Raviglione
Journal:  N Engl J Med       Date:  2015-05-28       Impact factor: 91.245

Review 2.  The balance between protective and pathogenic immune responses in the TB-infected lung.

Authors:  Ian M Orme; Richard T Robinson; Andrea M Cooper
Journal:  Nat Immunol       Date:  2015-01       Impact factor: 25.606

3.  Cytokine production at the site of disease in human tuberculosis.

Authors:  P F Barnes; S Lu; J S Abrams; E Wang; M Yamamura; R L Modlin
Journal:  Infect Immun       Date:  1993-08       Impact factor: 3.441

4.  A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab') fragment prolong survival of mice infected with Mycobacterium tuberculosis.

Authors:  B Hamasur; M Haile; A Pawlowski; U Schroder; G Kallenius; S B Svenson
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

5.  IL-10 inhibits mature fibrotic granuloma formation during Mycobacterium tuberculosis infection.

Authors:  Joshua C Cyktor; Bridget Carruthers; Rachel A Kominsky; Gillian L Beamer; Paul Stromberg; Joanne Turner
Journal:  J Immunol       Date:  2013-02-08       Impact factor: 5.422

6.  Anti-PD1 Antibody Treatment and the Development of Acute Pulmonary Tuberculosis.

Authors:  Kohei Fujita; Tsuyoshi Terashima; Tadashi Mio
Journal:  J Thorac Oncol       Date:  2016-07-14       Impact factor: 15.609

7.  Induction of a protective response with an IgA monoclonal antibody against Mycobacterium tuberculosis 16kDa protein in a model of progressive pulmonary infection.

Authors:  Yamilé López; Daniel Yero; Gustavo Falero-Diaz; Nesty Olivares; María E Sarmiento; Sergio Sifontes; Rosa L Solis; Jorge A Barrios; Diana Aguilar; Rogelio Hernández-Pando; Armando Acosta
Journal:  Int J Med Microbiol       Date:  2009-01-20       Impact factor: 3.473

8.  An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.

Authors:  Matthew P R Berry; Christine M Graham; Finlay W McNab; Zhaohui Xu; Susannah A A Bloch; Tolu Oni; Katalin A Wilkinson; Romain Banchereau; Jason Skinner; Robert J Wilkinson; Charles Quinn; Derek Blankenship; Ranju Dhawan; John J Cush; Asuncion Mejias; Octavio Ramilo; Onn M Kon; Virginia Pascual; Jacques Banchereau; Damien Chaussabel; Anne O'Garra
Journal:  Nature       Date:  2010-08-19       Impact factor: 49.962

9.  CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease.

Authors:  Shunsuke Sakai; Keith D Kauffman; Michelle A Sallin; Arlene H Sharpe; Howard A Young; Vitaly V Ganusov; Daniel L Barber
Journal:  PLoS Pathog       Date:  2016-05-31       Impact factor: 6.823

10.  Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers.

Authors:  Chloe I Bloom; Christine M Graham; Matthew P R Berry; Fotini Rozakeas; Paul S Redford; Yuanyuan Wang; Zhaohui Xu; Katalin A Wilkinson; Robert J Wilkinson; Yvonne Kendrick; Gilles Devouassoux; Tristan Ferry; Makoto Miyara; Diane Bouvry; Dominique Valeyre; Valeyre Dominique; Guy Gorochov; Derek Blankenship; Mitra Saadatian; Phillip Vanhems; Huw Beynon; Rama Vancheeswaran; Melissa Wickremasinghe; Damien Chaussabel; Jacques Banchereau; Virginia Pascual; Ling-Pei Ho; Marc Lipman; Anne O'Garra
Journal:  PLoS One       Date:  2013-08-05       Impact factor: 3.240
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  22 in total

1.  Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis.

Authors:  Lingming Chen; Guoliang Zhang; Guobao Li; Wei Wang; Zhenhuang Ge; Yi Yang; Xing He; Zhi Liu; Zhiyi Zhang; Qiongdan Mai; Yiwei Chen; Zixu Chen; Jiang Pi; Shuai Yang; Jun Cui; Haipeng Liu; Ling Shen; Lingchan Zeng; Lin Zhou; Xinchun Chen; Baoxue Ge; Zheng W Chen; Gucheng Zeng
Journal:  Nat Metab       Date:  2022-03-14

2.  c-di-AMP Accumulation Regulates Growth, Metabolism, and Immunogenicity of Mycobacterium smegmatis.

Authors:  Huanhuan Ning; Xuan Liang; Yanling Xie; Lu Bai; Wei Zhang; Lifei Wang; Jian Kang; Yanzhi Lu; Yanling Ma; Guangchun Bai; Yinlan Bai
Journal:  Front Microbiol       Date:  2022-05-24       Impact factor: 6.064

3.  Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered in Xenopus.

Authors:  Eva-Stina Edholm; Maureen Banach; Kun Hyoe Rhoo; Martin S Pavelka; Jacques Robert
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-02       Impact factor: 11.205

4.  Sterilizing immunity: New opportunities for rational TB vaccine design.

Authors:  Alan Sher; Joanne L Flynn
Journal:  J Exp Med       Date:  2021-05-26       Impact factor: 14.307

Review 5.  The Role of Dendritic Cells in TB and HIV Infection.

Authors:  Rachel Abrahem; Emerald Chiang; Joseph Haquang; Amy Nham; Yu-Sam Ting; Vishwanath Venketaraman
Journal:  J Clin Med       Date:  2020-08-17       Impact factor: 4.241

6.  The Profile of T Cell Responses in Bacille Calmette-Guérin-Primed Mice Boosted by a Novel Sendai Virus Vectored Anti-Tuberculosis Vaccine.

Authors:  Zhidong Hu; Ling Gu; Chun-Ling Li; Tsugumine Shu; Douglas B Lowrie; Xiao-Yong Fan
Journal:  Front Immunol       Date:  2018-08-03       Impact factor: 7.561

7.  CCR4-dependent reduction in the number and suppressor function of CD4+Foxp3+ cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis.

Authors:  Thais B Bertolini; Annie R Piñeros; Rafael Q Prado; Ana Flávia Gembre; Leandra N Z Ramalho; José Carlos Alves-Filho; Vânia L D Bonato
Journal:  Cell Death Dis       Date:  2018-12-21       Impact factor: 8.469

Review 8.  RNA Sensing of Mycobacterium tuberculosis and Its Impact on TB Vaccination Strategies.

Authors:  Sanne Burkert; Ralf R Schumann
Journal:  Vaccines (Basel)       Date:  2020-02-04

9.  Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions.

Authors:  Simran Kaur Arora; Anwar Alam; Nilofer Naqvi; Javeed Ahmad; Javaid Ahmad Sheikh; Syed Asad Rahman; Seyed Ehtesham Hasnain; Nasreen Zafar Ehtesham
Journal:  Front Immunol       Date:  2020-07-21       Impact factor: 7.561

Review 10.  Towards new TB vaccines.

Authors:  Benedict Brazier; Helen McShane
Journal:  Semin Immunopathol       Date:  2020-03-18       Impact factor: 9.623
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