Zi-Nan Wang1, Ping Li1, Ran-Hua Jiang2, Ling Li3, Xue Li2, Liang Li1, Cong Liu1, Cong-Liang Tian4. 1. Department of Endocrinology, Shengjing Hospital of China Medical University Shenyang 110004, Liaoning Province, PR China. 2. Liaoyang Diabetes Hospital Liaoyang 111000, Liaoning Province, PR China. 3. Department of Endocrinology, Shengjing Hospital of China Medical UniversityShenyang 110004, Liaoning Province, PR China; The Liaoning Provincial Key Laboratory of Endocrine DiseasesShenyang 111000, Liaoning Province, PR China. 4. Department of Pediatrics, The First Affiliated Hospital of Dalian Medical University Dalian 116011, Liaoning Province, PR China.
Abstract
PURPOSE: Data about the association between serum uric acid and metabolic syndrome in healthy adolescents are sparse. This study examined this association and determined the optimal cutoffs for serum uric acid to predict metabolic syndrome among healthy adolescents. METHODS: During 2010-2011, we conducted a cross-sectional study of 927 adolescents (53.0% boys) aged 11-16 years from junior and senior high schools in northeast China. All participants received a physical examination and gave venous blood samples. RESULTS: Serum uric acid was positively associated with abdominal obesity, dyslipidemia and hypertension in boys and with abdominal obesity and dyslipidemia in girls. For those with hyperurecemia, the odds ratios (95% CI) for metabolic syndrome were 7.67 (95% CI, 2.58~22.78) for boys and 4.77 (95% CI, 1.01~22.60) for girls. SUA was a better predictor of metabolic syndrome than fasting glucose, though not as good as waist circumference. CONCLUSIONS: Among adolescents in China, serum uric acid level may be a useful predictor of metabolic syndrome.
PURPOSE: Data about the association between serum uric acid and metabolic syndrome in healthy adolescents are sparse. This study examined this association and determined the optimal cutoffs for serum uric acid to predict metabolic syndrome among healthy adolescents. METHODS: During 2010-2011, we conducted a cross-sectional study of 927 adolescents (53.0% boys) aged 11-16 years from junior and senior high schools in northeast China. All participants received a physical examination and gave venous blood samples. RESULTS: Serum uric acid was positively associated with abdominal obesity, dyslipidemia and hypertension in boys and with abdominal obesity and dyslipidemia in girls. For those with hyperurecemia, the odds ratios (95% CI) for metabolic syndrome were 7.67 (95% CI, 2.58~22.78) for boys and 4.77 (95% CI, 1.01~22.60) for girls. SUA was a better predictor of metabolic syndrome than fasting glucose, though not as good as waist circumference. CONCLUSIONS: Among adolescents in China, serum uric acid level may be a useful predictor of metabolic syndrome.
Entities:
Keywords:
Adolescents; metabolic syndrome; public health; uric acid
Authors: Sonimar de Souza; Cézane P Reuter; Lars B Andersen; Rodrigo A Lima; Karin A Pfeiffer; Elza D de Mello; Anelise R Gaya; Silvia I R Franke; Jane D P Renner Journal: Pediatr Res Date: 2020-03-14 Impact factor: 3.756