Sonimar de Souza1, Cézane P Reuter2, Lars B Andersen3, Rodrigo A Lima4, Karin A Pfeiffer5, Elza D de Mello6, Anelise R Gaya7, Silvia I R Franke8, Jane D P Renner9. 1. Graduate Program in Health Promotion, University of Santa Cruz do Sul, Rio Grande do Sul, Brazil. 2. Department of Health Sciences, Graduate Program in Health Promotion, University of Santa Cruz do Sul, Rio Grande do Sul, Brazil. cezanereuter@unisc.br. 3. Western Norway University of Applied Sciences, Campus Sogndal, Bergen, Norway. 4. Institute of Sport Science, University of Graz, Graz, Austria. 5. Department of Kinesiology, Michigan State University, East Lansing, MI, USA. 6. Graduate Program in Child and Adolescent Health, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil. 7. Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil. 8. Department of Health Sciences, Graduate Program in Health Promotion, University of Santa Cruz do Sul, Rio Grande do Sul, Brazil. 9. Department of Life Sciences, Graduate Program in Health Promotion, University of Santa Cruz do Sul, Rio Grande do Sul, Brazil.
Abstract
BACKGROUND: The associations of renal, hepatic, and hematologic markers with metabolic risk (MR) have already been shown in adolescents. However, it is still controversial which marker best predicts metabolic changes in youth. The aim of this study was to verify the association of MR with alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid, and hemoglobin (Hb) in adolescents. METHODS: We evaluated 1713 Brazilian adolescents aged 10 to 17 years. MR was calculated using a continuous metabolic risk score, including the sum of Z-scores of waist circumference, systolic blood pressure, fasting glucose, high-density lipoproteins, triglycerides, and cardiorespiratory fitness. Cutoff points were set for MR prediction for five metabolic components (ALT, AST, AST/ALT ratio, uric acid, and Hb). RESULTS: MR was strongly associated with increased uric acid (odds ratio [OR]: 2.50; 95% confidence interval [CI]: 1.74-3.59), ALT (OR: 2.64; 95% CI: 1.63-4.27), and AST levels (OR: 2.53; 95% CI: 1.24-5.18). Uric acid was shown to be the best predictor for MR (sensitivity: 55.79%; specificity: 61.35%; area under the curve: 0.616). CONCLUSION: Elevated hepatic, renal, and hematological markers were associated with MR in adolescents, especially ALT, AST, and uric acid levels. IMPACT: Elevated hepatic, renal, and hematological markers were associated with metabolic risk in adolescents, especially ALT, AST, and uric acid levels. It is still controversial which marker best predicts metabolic changes in adolescents. In addition, association of Hb with metabolic risk is under-studied in this population. It is important to further investigate the relationship between elevated Hb and hepatic markers, since there are key aspects not addressed yet. Our results highlight the importance of creating public health policies aimed to child and adolescent population, to prevention of metabolic disorders from an early age.
BACKGROUND: The associations of renal, hepatic, and hematologic markers with metabolic risk (MR) have already been shown in adolescents. However, it is still controversial which marker best predicts metabolic changes in youth. The aim of this study was to verify the association of MR with alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid, and hemoglobin (Hb) in adolescents. METHODS: We evaluated 1713 Brazilian adolescents aged 10 to 17 years. MR was calculated using a continuous metabolic risk score, including the sum of Z-scores of waist circumference, systolic blood pressure, fasting glucose, high-density lipoproteins, triglycerides, and cardiorespiratory fitness. Cutoff points were set for MR prediction for five metabolic components (ALT, AST, AST/ALT ratio, uric acid, and Hb). RESULTS: MR was strongly associated with increased uric acid (odds ratio [OR]: 2.50; 95% confidence interval [CI]: 1.74-3.59), ALT (OR: 2.64; 95% CI: 1.63-4.27), and AST levels (OR: 2.53; 95% CI: 1.24-5.18). Uric acid was shown to be the best predictor for MR (sensitivity: 55.79%; specificity: 61.35%; area under the curve: 0.616). CONCLUSION: Elevated hepatic, renal, and hematological markers were associated with MR in adolescents, especially ALT, AST, and uric acid levels. IMPACT: Elevated hepatic, renal, and hematological markers were associated with metabolic risk in adolescents, especially ALT, AST, and uric acid levels. It is still controversial which marker best predicts metabolic changes in adolescents. In addition, association of Hb with metabolic risk is under-studied in this population. It is important to further investigate the relationship between elevated Hb and hepatic markers, since there are key aspects not addressed yet. Our results highlight the importance of creating public health policies aimed to child and adolescent population, to prevention of metabolic disorders from an early age.
Authors: M V B Malachias; V Koch; Colombo Colombo; Silva Silva; I C B Guimarães; P K Nogueira Journal: Arq Bras Cardiol Date: 2016-09 Impact factor: 2.000
Authors: Sonimar de Souza; João Francisco de Castro Silveira; Kelin Cristina Marques; Anelise Reis Gaya; Silvia Isabel Rech Franke; Jane Dagmar Pollo Renner; James Philip Hobkirk; Sean Carroll; Cézane Priscila Reuter Journal: BMC Pediatr Date: 2022-06-02 Impact factor: 2.567