Literature DB >> 26864582

Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome.

Mika Kondo1, Satoko Osuka1, Akira Iwase2,3, Tatsuo Nakahara1, Ai Saito1, Tomoko Nakamura1,4, Maki Goto1, Tomomi Kotani1, Fumitaka Kikkawa1.   

Abstract

Kisspeptin, a hypothalamic neuropeptide, is expressed in the arcuate nucleus (ARC) that is considered as the center of the gonadotropin-releasing hormone (GnRH)-pulse generator. We hypothesized that kisspeptin expressed in the ARC is implicated in the disturbance of the hypothalamus-pituitary-ovary axis observed in polycystic ovary syndrome (PCOS). To test this hypothesis, we evaluated the hormonal profiles, luteinizing hormone (LH) pulse, and ARC kisspeptin immunoreactivity in a PCOS rat model using the anti-progestin RU486. We found an alteration of the LH pulse, including a trend towards an increased mean LH concentration and area under the curve, and a significant upregulation of the mean LH pulse amplitude. Additionally, a higher number of kisspeptin-positive cells was observed in the ARC of RU486-treated rats than in the ARC of intact rats. These results suggest the possible involvement of hypothalamic kisspeptin in the hypothalamus-pituitary-ovary axis and therefore, in PCOS pathophysiology.

Entities:  

Keywords:  Kisspeptin; LH pulse; PCOS; RU486

Mesh：

Substances：

Year:  2016        PMID： 26864582     DOI： 10.1007/s11011-016-9807-0

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  43 in total

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Review 2.  Polycystic ovary syndrome.

Authors:  S Franks
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Journal:  PLoS One       Date:  2009-12-16       Impact factor: 3.240
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3.  Effect of Sleeve Gastrectomy on Kisspeptin Expression in the Hypothalamus of Rats with Polycystic Ovary Syndrome.

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Review 4.  Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides.

Authors:  Satoko Osuka; Natsuki Nakanishi; Tomohiko Murase; Tomoko Nakamura; Maki Goto; Akira Iwase; Fumitaka Kikkawa
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5.  Kisspeptin and LH pulsatile temporal coupling in PCOS patients.

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Journal:  Endocrine       Date:  2018-05-04       Impact factor: 3.633

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7.  Expression of the anti-Mullerian hormone, kisspeptin 1, and kisspeptin 1 receptor in polycystic ovary syndrome and controlled ovarian stimulation rat models.

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8.  Effect of Vitex agnus-castus ethanolic extract on hypothalamic KISS-1 gene expression in a rat model of polycystic ovary syndrome.

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  8 in total

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