| Literature DB >> 26857488 |
Tiffany C Blair1, Minsha Manoharan2, Stephanie D Rawlings-Rhea3, Ian Tagge4, Steven G Kohama5, Julie Hollister-Smith6, Betsy Ferguson7, Randall L Woltjer8, Meredith C Frederick9, James Pollaro10, William D Rooney11, Larry S Sherman12, Dennis N Bourdette13, Scott W Wong14.
Abstract
Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.Entities:
Keywords: Demyelination; Inflammatory; Interleukin 17 (IL-17); Intrathecal IgG; Magnetic resonance imaging (MRI); Th1; Th17
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Year: 2015 PMID： 26857488 PMCID： PMC4748211 DOI： 10.1016/j.jneuroim.2015.11.026
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478