Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae.

Literature DB >> 2685557

Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae.

J M Song¹, S Picologlou, C M Grant, M Firoozan, M F Tuite, S Liebman.

Abstract

Changes in the dosage of genes encoding elongation factor EF-1 alpha were shown to cause parallel changes in the misreading of nonsense codons. Higher amounts of EF-1 alpha were correlated with increased nonsense suppression, suggesting that the level of EF-1 alpha is critically involved in translational fidelity.

Entities: Species

Mesh：

Substances：

Year: 1989 PMID： 2685557 PMCID： PMC362547 DOI： 10.1128/mcb.9.10.4571-4575.1989

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

34 in total

1. Isolation and characterization of amber suppressors in yeast.

Authors: S W Liebman; F Sherman; J W Stewart
Journal: Genetics Date: 1976-02 Impact factor: 4.562

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

4. Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae.

Authors: M G Sandbaken; M R Culbertson
Journal: Genetics Date: 1988-12 Impact factor: 4.562

5. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

Review 6. The role of guanosine 5'-triphosphate in polypeptide chain elongation.

Authors: Y Kaziro
Journal: Biochim Biophys Acta Date: 1978-09-21

7. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

8. Structural analysis and sequence organization of yeast centromeres.

Authors: K S Bloom; M Fitzgerald-Hayes; J Carbon
Journal: Cold Spring Harb Symp Quant Biol Date: 1983

9. An antisuppressor that acts on omnipotent suppressors in yeast.

Authors: S W Liebman; M Cavenagh
Journal: Genetics Date: 1980-05 Impact factor: 4.562

10. Transformation of intact yeast cells treated with alkali cations.

Authors: H Ito; Y Fukuda; K Murata; A Kimura
Journal: J Bacteriol Date: 1983-01 Impact factor: 3.490

30 in total

1. Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.

Authors: K Czaplinski; N Majlesi; T Banerjee; S W Peltz
Journal: RNA Date: 2000-05 Impact factor: 4.942

9. Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display.

Authors: R Shen; Z Z Su; C A Olsson; P B Fisher
Journal: Proc Natl Acad Sci U S A Date: 1995-07-18 Impact factor: 11.205

10. Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta.

Authors: T G Kinzy; J L Woolford
Journal: Genetics Date: 1995-10 Impact factor: 4.562

Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae.

1. Isolation and characterization of amber suppressors in yeast.

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

4. Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae.

5. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Review 6. The role of guanosine 5'-triphosphate in polypeptide chain elongation.

7. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

8. Structural analysis and sequence organization of yeast centromeres.

9. An antisuppressor that acts on omnipotent suppressors in yeast.

10. Transformation of intact yeast cells treated with alkali cations.

1. Mtt1 is a Upf1-like helicase that interacts with the translation termination factors and whose overexpression can modulate termination efficiency.

2. Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis.

3. Nucleotide sequence of rabbit elongation factor 1 alpha cDNA.

Review 4. Mechanism and regulation of eukaryotic protein synthesis.

5. Developmental analysis of elongation factor-1 alpha expression in transgenic tobacco.

6. Interactions between chromosomal omnipotent suppressors and extrachromosomal effectors in Saccharomyces cerevisiae.

7. Structure comparison and evolutionary relations between elongation factors EF-Tu (EF-1 alpha) and SUP 2 proteins.

Review 8. Modulation of efficiency of translation termination in Saccharomyces cerevisiae.

9. Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display.

10. Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta.