Román Carlos1, Bruno Augusto Benevenuto de Andrade2, Nathalie Henriques Silva Canedo3, Aline Corrêa Abrahão2, Michelle Agostini2, Oslei Paes de Almeida4, Mário José Romañach5. 1. Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala. 2. Department of Oral Diagnosis and Pathology, Federal University of Rio de Janeiro School of Dentistry, Rio de Janeiro, Brazil. 3. Department of Pathology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro School of Medicine, Rio de Janeiro, Brazil. 4. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. 5. Department of Oral Diagnosis and Pathology, Federal University of Rio de Janeiro School of Dentistry, Rio de Janeiro, Brazil. Electronic address: Marioromanach@ufrj.br.
Abstract
OBJECTIVE: To describe the clinicopathologic and immunohistochemical features of five cases of oral solitary fibrous tumor. STUDY DESIGN: Clinical data were collected from charts of two oral pathology laboratories of Latin America. All cases were evaluated by conventional hematoxylin and eosin staining and an extended immunohistochemical panel comprising vimentin, CD34, CD99, bcl-2, HHF-35, smooth muscle actin, calponin, S-100 protein, h-caldesmon, and Ki-67. RESULTS: The study included 1 male (20%) and 4 female (80%) patients, with a median age of 43 years. The most common affected site was the buccal mucosa (40%). Tumors were characterized by proliferation of spindled and ovoid cells in a variably vascular and collagenized stroma. All tumors were positive for vimentin, CD34, bcl-2, and CD99. Recurrence was not observed after complete surgical enucleation. CONCLUSIONS: Oral solitary fibrous tumors usually appear as well-delimited submucous nodules with a firm-rubbery consistency and covered by intact mucosa. Immunoreactivity for CD34, bcl-2, and CD-99 is helpful to confirm the diagnosis.
OBJECTIVE: To describe the clinicopathologic and immunohistochemical features of five cases of oral solitary fibrous tumor. STUDY DESIGN: Clinical data were collected from charts of two oral pathology laboratories of Latin America. All cases were evaluated by conventional hematoxylin and eosin staining and an extended immunohistochemical panel comprising vimentin, CD34, CD99, bcl-2, HHF-35, smooth muscle actin, calponin, S-100 protein, h-caldesmon, and Ki-67. RESULTS: The study included 1 male (20%) and 4 female (80%) patients, with a median age of 43 years. The most common affected site was the buccal mucosa (40%). Tumors were characterized by proliferation of spindled and ovoid cells in a variably vascular and collagenized stroma. All tumors were positive for vimentin, CD34, bcl-2, and CD99. Recurrence was not observed after complete surgical enucleation. CONCLUSIONS: Oral solitary fibrous tumors usually appear as well-delimited submucous nodules with a firm-rubbery consistency and covered by intact mucosa. Immunoreactivity for CD34, bcl-2, and CD-99 is helpful to confirm the diagnosis.