J J Stefanik1, A Guermazi2, F W Roemer3, G Peat4, J Niu5, N A Segal6, C E Lewis7, M Nevitt8, D T Felson9. 1. Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, USA; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA. Electronic address: j.stefanik@northeastern.edu. 2. Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA. Electronic address: ali.guermazi@bmc.org. 3. Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany. Electronic address: frank.roemer@klinikum-augsburg.de. 4. Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom. Electronic address: g.m.peat@keele.ac.uk. 5. Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA. Electronic address: niujp@bu.edu. 6. Department of Epidemiology, The University of Iowa, Iowa City, IA, USA; Department of Rehabilitation Medicine, University of Kansas, Kansas City, KS, USA. Electronic address: neil-nsegal@kumc.edu. 7. Department of Medicine, UAB, Birmingham, AB, USA. Electronic address: celewis@uabmc.edu. 8. Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA. Electronic address: mnevitt@psg.ucsf.edu. 9. Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA. Electronic address: dfelson@bu.edu.
Abstract
OBJECTIVES: To investigate changes in cartilage damage and bone marrow lesions (BMLs) on MRI in the patellofemoral and tibiofemoral joints (TFJs) over 7 years. METHODS: The Multicenter Osteoarthritis (MOST) Study is a cohort study of persons aged 50-79 years at baseline with or at high risk for knee osteoarthritis (OA). Knees were eligible for the current study if they had knee MRI (1.0T) assessed for cartilage damage and BMLs at the baseline and 84-month visits. Knees were categorized as having MRI-detected structural damage (cartilage and BMLs) isolated to the patellofemoral joint (PFJ), isolated to the TFJ, mixed or no damage at baseline and 84-months. We determined the changes in PFJ and TFJ structural damage over 7 years and used logistic regression to assess the relation of baseline compartment distribution to incident isolated PFJ, isolated TFJ and mixed damage. RESULTS: Among 339 knees that had full-thickness cartilage loss isolated to the PFJ or TFJ at baseline, only 68 (20.1%) developed full-thickness cartilage loss in the other compartment while 271 (79.9%) continued to only have the initial compartment affected. Compared to knees without full-thickness cartilage damage (n = 582), those with isolated TFJ and PFJ full-thickness cartilage damage had 2.7 (1.5, 4.9) and 5.8 (3.6, 9.6) times the odds of incident mixed full-thickness cartilage damage, respectively. Similar results were seen when using other definitions of MRI-defined structural damage. CONCLUSIONS: Most knees with structural damage at baseline do not develop it in the other compartment. Knees that develop mixed structural damage are more likely to start with it isolated to the PFJ.
OBJECTIVES: To investigate changes in cartilage damage and bone marrow lesions (BMLs) on MRI in the patellofemoral and tibiofemoral joints (TFJs) over 7 years. METHODS: The Multicenter Osteoarthritis (MOST) Study is a cohort study of persons aged 50-79 years at baseline with or at high risk for knee osteoarthritis (OA). Knees were eligible for the current study if they had knee MRI (1.0T) assessed for cartilage damage and BMLs at the baseline and 84-month visits. Knees were categorized as having MRI-detected structural damage (cartilage and BMLs) isolated to the patellofemoral joint (PFJ), isolated to the TFJ, mixed or no damage at baseline and 84-months. We determined the changes in PFJ and TFJ structural damage over 7 years and used logistic regression to assess the relation of baseline compartment distribution to incident isolated PFJ, isolated TFJ and mixed damage. RESULTS: Among 339 knees that had full-thickness cartilage loss isolated to the PFJ or TFJ at baseline, only 68 (20.1%) developed full-thickness cartilage loss in the other compartment while 271 (79.9%) continued to only have the initial compartment affected. Compared to knees without full-thickness cartilage damage (n = 582), those with isolated TFJ and PFJ full-thickness cartilage damage had 2.7 (1.5, 4.9) and 5.8 (3.6, 9.6) times the odds of incident mixed full-thickness cartilage damage, respectively. Similar results were seen when using other definitions of MRI-defined structural damage. CONCLUSIONS: Most knees with structural damage at baseline do not develop it in the other compartment. Knees that develop mixed structural damage are more likely to start with it isolated to the PFJ.
Authors: D J Hunter; W Harvey; K D Gross; D Felson; P McCree; L Li; K Hirko; B Zhang; K Bennell Journal: Osteoarthritis Cartilage Date: 2011-01-11 Impact factor: 6.576
Authors: Neil A Segal; Michael C Nevitt; K Douglas Gross; Keith D Gross; Jean Hietpas; Natalie A Glass; Cora E Lewis; James C Torner Journal: PM R Date: 2013-08 Impact factor: 2.298
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: M K Javaid; J A Lynch; I Tolstykh; A Guermazi; F Roemer; P Aliabadi; C McCulloch; J Curtis; D Felson; N E Lane; J Torner; M Nevitt Journal: Osteoarthritis Cartilage Date: 2009-11-11 Impact factor: 6.576
Authors: Leena Sharma; Joan S Chmiel; Orit Almagor; Dorothy Dunlop; Ali Guermazi; Joan M Bathon; Charles B Eaton; Marc C Hochberg; Rebecca D Jackson; C Kent Kwoh; W Jerry Mysiw; Michel D Crema; Frank W Roemer; Michael C Nevitt Journal: Arthritis Rheumatol Date: 2014-07 Impact factor: 10.995
Authors: Kay M Crossley; Bill Vicenzino; Marcus G Pandy; Anthony G Schache; Rana S Hinman Journal: BMC Musculoskelet Disord Date: 2008-09-16 Impact factor: 2.362
Authors: E M Macri; D T Felson; M L Ziegler; T D V Cooke; A Guermazi; F W Roemer; T Neogi; J Torner; C E Lewis; M C Nevitt; J J Stefanik Journal: Osteoarthritis Cartilage Date: 2018-11-28 Impact factor: 6.576
Authors: L F Schaefer; M Sury; M Yin; S Jamieson; I Donnell; S E Smith; J A Lynch; M C Nevitt; J Duryea Journal: Osteoarthritis Cartilage Date: 2017-01-30 Impact factor: 6.576
Authors: H F Hart; K M Crossley; D Felson; M Jarraya; A Guermazi; F Roemer; C E Lewis; J Torner; M Nevitt; J J Stefanik Journal: Osteoarthritis Cartilage Date: 2018-02-07 Impact factor: 6.576
Authors: Erin M Macri; Tuhina Neogi; Irina Tolstykh; Rafael Widjajahakim; Cora E Lewis; James C Torner; Michael C Nevitt; Michael Roux; Joshua J Stefanik Journal: Arthritis Care Res (Hoboken) Date: 2020-07-03 Impact factor: 4.794
Authors: M Jarraya; A Guermazi; D T Felson; F W Roemer; M C Nevitt; J Torner; C E Lewis; J J Stefanik Journal: Osteoarthritis Cartilage Date: 2017-06-09 Impact factor: 6.576
Authors: E M Macri; D T Felson; Y Zhang; A Guermazi; F W Roemer; K M Crossley; K M Khan; J J Stefanik Journal: Osteoarthritis Cartilage Date: 2017-06-23 Impact factor: 6.576
Authors: Harvi F Hart; Tuhina Neogi; Michael LaValley; Daniel White; Yuqing Zhang; Michael C Nevitt; James Torner; Cora E Lewis; Joshua J Stefanik Journal: J Rheumatol Date: 2021-09-01 Impact factor: 4.666
Authors: N A Segal; M T Murphy; B M Everist; K D Brown; J He; J A Lynch; M C Nevitt Journal: Osteoarthritis Cartilage Date: 2021-07-29 Impact factor: 6.576