M Jarraya1, A Guermazi2, D T Felson3, F W Roemer4, M C Nevitt5, J Torner6, C E Lewis7, J J Stefanik8. 1. Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States; Department of Radiology, Mercy Catholic Medical Center, Darby, PA, United States. Electronic address: mohamedjarraya@gmail.com. 2. Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States. 3. Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, United States. 4. Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany. 5. Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, United States. 6. Department of Epidemiology, University of Iowa, Iowa City, IA, United States. 7. Department of Medicine, UAB Medicine, Birmingham, AL, United States. 8. Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, United States; Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, United States.
Abstract
PURPOSE: To determine the relation of superolateral Hoffa's fat pad (SHFP) hyperintensity to cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and tibiofemoral joint (TFJ). METHODS: We used data from the 60 and 84-month study visits from the Multicenter Osteoarthritis (MOST) study. SHFP hyperintensity and Hoffa-synovitis were graded from 0 to 3. Cartilage damage and BMLs were scored in the PFJ and TFJ. Structural damage was defined as: any cartilage damage, full-thickness cartilage damage and any BML. Worsening structural damage was defined as any increase in cartilage and BML scores. Logistic regression was used to determine the relation of SHFP hyperintensity and Hoffa-synovitis (>0) to structural damage, adjusting for age, sex and body mass index (BMI). RESULTS: 1,094 knees were included in the study. Compared to knees without SHFP hyperintensity, those with SHFP hyperintensity had 1.2 (95% Confidence Interval (CI), 1.1-1.4), 1.7 (1.3-2.3) and 1.6 (1.3-1.9) times the prevalence of any cartilage damage, full-thickness cartilage damage, and BMLs in the lateral PFJ respectively, and 1.1 (1.0-1.2), 1.3 (1.0-1.8), and 1.2 (1.0-1.4) times the prevalence of any cartilage damage, full-thickness cartilage damage, and BMLs in the medial PFJ. SHFP hyperintensity was associated with worsening BMLs in the medial PFJ (RR: 1.4 (1.0-1.9)). In general, there was no relation between SHFP hyperintensity and TFJ outcomes. Hoffa-synovitis was associated both cross-sectionally and longitudinally with structural damage, regardless of definition, in all compartments. CONCLUSION: SHFP hyperintensity may be a local marker of PFJ structural damage.
PURPOSE: To determine the relation of superolateral Hoffa's fat pad (SHFP) hyperintensity to cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and tibiofemoral joint (TFJ). METHODS: We used data from the 60 and 84-month study visits from the Multicenter Osteoarthritis (MOST) study. SHFP hyperintensity and Hoffa-synovitis were graded from 0 to 3. Cartilage damage and BMLs were scored in the PFJ and TFJ. Structural damage was defined as: any cartilage damage, full-thickness cartilage damage and any BML. Worsening structural damage was defined as any increase in cartilage and BML scores. Logistic regression was used to determine the relation of SHFP hyperintensity and Hoffa-synovitis (>0) to structural damage, adjusting for age, sex and body mass index (BMI). RESULTS: 1,094 knees were included in the study. Compared to knees without SHFP hyperintensity, those with SHFP hyperintensity had 1.2 (95% Confidence Interval (CI), 1.1-1.4), 1.7 (1.3-2.3) and 1.6 (1.3-1.9) times the prevalence of any cartilage damage, full-thickness cartilage damage, and BMLs in the lateral PFJ respectively, and 1.1 (1.0-1.2), 1.3 (1.0-1.8), and 1.2 (1.0-1.4) times the prevalence of any cartilage damage, full-thickness cartilage damage, and BMLs in the medial PFJ. SHFP hyperintensity was associated with worsening BMLs in the medial PFJ (RR: 1.4 (1.0-1.9)). In general, there was no relation between SHFP hyperintensity and TFJ outcomes. Hoffa-synovitis was associated both cross-sectionally and longitudinally with structural damage, regardless of definition, in all compartments. CONCLUSION: SHFP hyperintensity may be a local marker of PFJ structural damage.
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Authors: J J Stefanik; A Guermazi; F W Roemer; G Peat; J Niu; N A Segal; C E Lewis; M Nevitt; D T Felson Journal: Osteoarthritis Cartilage Date: 2016-02-04 Impact factor: 6.576
Authors: Arya Haj-Mirzaian; Ali Guermazi; Nima Hafezi-Nejad; Christopher Sereni; Michael Hakky; David J Hunter; Bashir Zikria; Frank W Roemer; Shadpour Demehri Journal: Eur Radiol Date: 2018-04-12 Impact factor: 5.315
Authors: Kang Wang; Changhai Ding; Michael J Hannon; Zhongshan Chen; C Kent Kwoh; David J Hunter Journal: Arthritis Care Res (Hoboken) Date: 2019-01 Impact factor: 4.794
Authors: Arya Haj-Mirzaian; Ali Guermazi; Michael Hakky; Christopher Sereni; Bashir Zikria; Frank W Roemer; Miho J Tanaka; Andrew J Cosgarea; Shadpour Demehri Journal: Eur Radiol Date: 2018-04-30 Impact factor: 5.315
Authors: Mohamed Jarraya; Frank W Roemer; Lars Engebretsen; Andrew J Kompel; Kirstin M Small; Stacy E Smith; Ali Guermazi Journal: Eur J Radiol Open Date: 2021-10-04