Literature DB >> 26833148

The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri.

Evgeny A Idelevich1, Frieder Schaumburg1, Dennis Knaack1, Anna S Scherzinger2, Wolfgang Mutter2, Georg Peters1, Andreas Peschel3, Karsten Becker4.   

Abstract

HY-133 is a recombinant bacteriophage endolysin with bactericidal activity againstStaphylococcus aureus Here, HY-133 showedin vitroactivity against major African methicillin-susceptible and methicillin-resistantS. aureuslineages and ceftaroline/ceftobiprole- and borderline oxacillin-resistant isolates. HY-133 was also active againstStaphylococcus schweitzeri, a recently described species of theS. aureuscomplex. The activity of HY-133 on the tested isolates (MIC50, 0.25 μg/ml; MIC90, 0.5 μg/ml; range, 0.125 to 0.5 μg/ml) was independent of the species and strain background or antibiotic resistance.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26833148      PMCID： PMC4808236          DOI： 10.1128/AAC.02859-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Transmission of Staphylococcus aureus between mothers and infants in an African setting.

Authors:  F Schaumburg; A S Alabi; G Mombo-Ngoma; H Kaba; R M Zoleko; D A Diop; J-R Mackanga; A Basra; R Gonzalez; C Menendez; M P Grobusch; P G Kremsner; R Köck; G Peters; M Ramharter; K Becker
Journal:  Clin Microbiol Infect       Date:  2013-11-18       Impact factor: 8.067

Review 2.  New epidemiology of Staphylococcus aureus infection in Africa.

Authors:  F Schaumburg; A S Alabi; G Peters; K Becker
Journal:  Clin Microbiol Infect       Date:  2014-07-12       Impact factor: 8.067

3.  In vitro activity against Staphylococcus aureus of a novel antimicrobial agent, PRF-119, a recombinant chimeric bacteriophage endolysin.

Authors:  Evgeny A Idelevich; Christof von Eiff; Alexander W Friedrich; Domenico Iannelli; Guoqing Xia; Georg Peters; Andreas Peschel; Ingrid Wanninger; Karsten Becker
Journal:  Antimicrob Agents Chemother       Date:  2011-07-11       Impact factor: 5.191

4.  Staphylococcus aureus complex from animals and humans in three remote African regions.

Authors:  Frieder Schaumburg; Maude Pauly; Etile Anoh; Arsene Mossoun; Lidewij Wiersma; Grit Schubert; Arnaud Flammen; Abraham S Alabi; Jean-Jacques Muyembe-Tamfum; Martin P Grobusch; Stomy Karhemere; Chantal Akoua-Koffi; Emmanuel Couacy-Hymann; Peter G Kremsner; Alexander Mellmann; Karsten Becker; Fabian H Leendertz; Georg Peters
Journal:  Clin Microbiol Infect       Date:  2014-12-11       Impact factor: 8.067

5.  Virulence factors and genotypes of Staphylococcus aureus from infection and carriage in Gabon.

Authors:  F Schaumburg; U Ateba Ngoa; K Kösters; R Köck; A A Adegnika; P G Kremsner; B Lell; G Peters; A Mellmann; K Becker
Journal:  Clin Microbiol Infect       Date:  2011-05-20       Impact factor: 8.067

6.  Drug-resistant human Staphylococcus aureus in sanctuary apes pose a threat to endangered wild ape populations.

Authors:  Frieder Schaumburg; Lawrence Mugisha; Bruce Peck; Karsten Becker; Thomas R Gillespie; Georg Peters; Fabian H Leendertz
Journal:  Am J Primatol       Date:  2012-08-21       Impact factor: 2.371

7.  Cross-linked peptidoglycan mediates lysostaphin binding to the cell wall envelope of Staphylococcus aureus.

Authors:  Angelika Gründling; Olaf Schneewind
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

8.  Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov.

Authors:  Steven Y C Tong; Frieder Schaumburg; Matthew J Ellington; Jukka Corander; Bruno Pichon; Fabian Leendertz; Stephen D Bentley; Julian Parkhill; Deborah C Holt; Georg Peters; Philip M Giffard
Journal:  Int J Syst Evol Microbiol       Date:  2014-09-30       Impact factor: 2.747

9.  Population dynamics of Staphylococcus aureus from Northeastern Nigeria in 2007 and 2012.

Authors:  K O Okon; A O Shittu; A A Kudi; H Umar; K Becker; F Schaumburg
Journal:  Epidemiol Infect       Date:  2013-12-05       Impact factor: 4.434

10.  MRSA in Africa: filling the global map of antimicrobial resistance.

Authors:  Matthew E Falagas; Drosos E Karageorgopoulos; John Leptidis; Ioanna P Korbila
Journal:  PLoS One       Date:  2013-07-29       Impact factor: 3.240
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  14 in total

1.  The Novel Phage-Derived Antimicrobial Agent HY-133 Is Active against Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

Authors:  Ursula Kaspar; Jorge A de Haro Sautto; Sonja Molinaro; Georg Peters; Evgeny A Idelevich; Karsten Becker
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

2.  Identification of Peptidoglycan Hydrolase Constructs with Synergistic Staphylolytic Activity in Cow's Milk.

Authors:  Carolin T Verbree; Steven M Dätwyler; Susanne Meile; Fritz Eichenseher; David M Donovan; Martin J Loessner; Mathias Schmelcher
Journal:  Appl Environ Microbiol       Date:  2017-03-17       Impact factor: 4.792

Review 3.  Recombinant Endolysins as Potential Therapeutics against Antibiotic-Resistant Staphylococcus aureus: Current Status of Research and Novel Delivery Strategies.

Authors:  Hamed Haddad Kashani; Mathias Schmelcher; Hamed Sabzalipoor; Elahe Seyed Hosseini; Rezvan Moniri
Journal:  Clin Microbiol Rev       Date:  2017-11-29       Impact factor: 26.132

4.  Corrected and Republished from: Identification of Peptidoglycan Hydrolase Constructs with Synergistic Staphylolytic Activity in Cow's Milk.

Authors:  Carolin T Verbree; Steven M Dätwyler; Susanne Meile; Fritz Eichenseher; David M Donovan; Martin J Loessner; Mathias Schmelcher
Journal:  Appl Environ Microbiol       Date:  2017-12-15       Impact factor: 4.792

5.  Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128.

Authors:  Nethravathi Poonacha; Sandhya Nair; Srividya Desai; Darshan Tuppad; Deepika Hiremath; Thulasi Mohan; Aradhana Vipra; Umender Sharma
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

6.  Comparative in vitro activity of bacteriophage endolysin HY-133 against Staphylococcus aureus attached to vascular graft surface.

Authors:  Evgeny A Idelevich; Dennis Knaack; Nyityasmono Tri Nugroho; Georg Peters; Theodosios Bisdas; Sonja Molinaro; Giovanni B Torsello; Karsten Becker; Monika Herten
Journal:  Med Microbiol Immunol       Date:  2019-10-17       Impact factor: 3.402

7.  Rapid in Vitro Quantification of S. aureus Biofilms on Vascular Graft Surfaces.

Authors:  Monika Herten; Theodosios Bisdas; Dennis Knaack; Karsten Becker; Nani Osada; Giovanni B Torsello; Evgeny A Idelevich
Journal:  Front Microbiol       Date:  2017-12-05       Impact factor: 5.640

8.  Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus.

Authors:  Karsten Becker; Sarah van Alen; Evgeny A Idelevich; Nina Schleimer; Jochen Seggewiß; Alexander Mellmann; Ursula Kaspar; Georg Peters
Journal:  Emerg Infect Dis       Date:  2018-02       Impact factor: 6.883

9.  Vascular Graft Impregnation with Antibiotics: The Influence of High Concentrations of Rifampin, Vancomycin, Daptomycin, and Bacteriophage Endolysin HY-133 on Viability of Vascular Cells.

Authors:  Monika Herten; Evgeny A Idelevich; Sonja Sielker; Karsten Becker; Anna S Scherzinger; Nani Osada; Giovanni B Torsello; Theodosios Bisdas
Journal:  Med Sci Monit Basic Res       Date:  2017-06-27

10.  1st German Phage Symposium-Conference Report.

Authors:  Irene Huber; Katerina Potapova; Andreas Kuhn; Herbert Schmidt; Jörg Hinrichs; Christine Rohde; Wolfgang Beyer
Journal:  Viruses       Date:  2018-03-29       Impact factor: 5.048
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