Literature DB >> 29735560

The Novel Phage-Derived Antimicrobial Agent HY-133 Is Active against Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

Ursula Kaspar1, Jorge A de Haro Sautto2, Sonja Molinaro3, Georg Peters2, Evgeny A Idelevich2, Karsten Becker2.   

Abstract

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage endolysin HY-133 has proved to be an active agent against S. aureus Here, the in vitro activity of HY-133 was studied against a large collection of genetically diverse LA-MRSA isolates revealing its high activity against mecA-, mecB-, and mecC-positive LA-MRSA.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  LA-MRSA; Staphylococcus aureus; antimicrobial agents; bacteriophage therapy; endolysin; livestock; susceptibility testing

Mesh：

Substances：

Year:  2018        PMID： 29735560      PMCID： PMC6021658          DOI： 10.1128/AAC.00385-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  40 in total

Review 1.  The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Germany.

Authors:  Robin Köck; Alexander Mellmann; Frieder Schaumburg; Alexander W Friedrich; Frank Kipp; Karsten Becker
Journal:  Dtsch Arztebl Int       Date:  2011-11-04       Impact factor: 5.594

Review 2.  Bacteriophage resistance mechanisms.

Authors:  Simon J Labrie; Julie E Samson; Sylvain Moineau
Journal:  Nat Rev Microbiol       Date:  2010-03-29       Impact factor: 60.633

3.  Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates collected from diseased food-producing animals in the GERM-Vet monitoring program 2008-2014.

Authors:  Geovana Brenner Michael; Heike Kaspar; Amanda Keller Siqueira; Eduardo de Freitas Costa; Luís Gustavo Corbellini; Kristina Kadlec; Stefan Schwarz
Journal:  Vet Microbiol       Date:  2016-09-01       Impact factor: 3.293

4.  EUREGIO MRSA-net Twente/Münsterland--a Dutch-German cross-border network for the prevention and control of infections caused by methicillin-resistant Staphylococcus aureus.

Authors:  A W Friedrich; I Daniels-Haardt; R Köck; F Verhoeven; A Mellmann; D Harmsen; J E van Gemert-Pijnen; K Becker; M G R Hendrix
Journal:  Euro Surveill       Date:  2008-08-28

Review 5.  Recombinant bacteriophage lysins as antibacterials.

Authors:  Mark Fenton; Paul Ross; Olivia McAuliffe; Jim O'Mahony; Aidan Coffey
Journal:  Bioeng Bugs       Date:  2010 Jan-Feb

Review 6.  Bacteriophage endolysins as novel antimicrobials.

Authors:  Mathias Schmelcher; David M Donovan; Martin J Loessner
Journal:  Future Microbiol       Date:  2012-10       Impact factor: 3.165

Review 7.  Infection prevention in a connected world: the case for a regional approach.

Authors:  Mariano Ciccolini; Tjibbe Donker; Robin Köck; Martin Mielke; Ron Hendrix; Annette Jurke; Janette Rahamat-Langendoen; Karsten Becker; Hubert G M Niesters; Hajo Grundmann; Alexander W Friedrich
Journal:  Int J Med Microbiol       Date:  2013-03-13       Impact factor: 3.473

8.  The clinical impact of livestock-associated methicillin-resistant Staphylococcus aureus of the clonal complex 398 for humans.

Authors:  Karsten Becker; Britta Ballhausen; Barbara C Kahl; Robin Köck
Journal:  Vet Microbiol       Date:  2015-11-22       Impact factor: 3.293

9.  The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri.

Authors:  Evgeny A Idelevich; Frieder Schaumburg; Dennis Knaack; Anna S Scherzinger; Wolfgang Mutter; Georg Peters; Andreas Peschel; Karsten Becker
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

10.  Livestock-associated MRSA carriage in patients without direct contact with livestock.

Authors:  Miranda M L van Rijen; Thijs Bosch; Erwin J M Verkade; Leo Schouls; Jan A J W Kluytmans
Journal:  PLoS One       Date:  2014-06-27       Impact factor: 3.240
View more
  3 in total

1.  In Vitro Activity of the Bacteriophage Endolysin HY-133 against Staphylococcus aureus Small-Colony Variants and Their Corresponding Wild Types.

Authors:  Nina Schleimer; Ursula Kaspar; Dennis Knaack; Christof von Eiff; Sonja Molinaro; Holger Grallert; Evgeny A Idelevich; Karsten Becker
Journal:  Int J Mol Sci       Date:  2019-02-07       Impact factor: 5.923

2.  Exploration of Bacterial Re-Growth as In Vitro Phenomenon Affecting Methods for Analysis of the Antimicrobial Activity of Chimeric Bacteriophage Endolysins.

Authors:  Ursula Kaspar; Nina Schleimer; Evgeny A Idelevich; Sonja Molinaro; Karsten Becker
Journal:  Microorganisms       Date:  2022-02-15

3.  Identification of a phage-derived depolymerase specific for KL47 capsule of Klebsiella pneumoniae and its therapeutic potential in mice.

Authors:  Min Li; Hui Wang; Long Chen; Genglin Guo; Pei Li; Jiale Ma; Rong Chen; Hong Du; Yuqing Liu; Wei Zhang
Journal:  Virol Sin       Date:  2022-05-02       Impact factor: 6.947
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.