Literature DB >> 26829220

The MCM Helicase Motor of the Eukaryotic Replisome.

Ferdos Abid Ali1, Alessandro Costa2.   

Abstract

The MCM motor of the CMG helicase powers ahead of the eukaryotic replication machinery to unwind DNA, in a process that requires ATP hydrolysis. The reconstitution of DNA replication in vitro has established the succession of events that lead to replication origin activation by the MCM and recent studies have started to elucidate the structural basis of duplex DNA unwinding. Despite the exciting progress, how the MCM translocates on DNA remains a matter of debate.
Copyright © 2016. Published by Elsevier Ltd.

Entities:  

Keywords:  AAA+ ATPase; DNA replication; MCM helicase; molecular motor; replication origin activation

Mesh：

Substances：

Year:  2016        PMID： 26829220     DOI： 10.1016/j.jmb.2016.01.024

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  16 in total

1.  Mechanisms of opening and closing of the bacterial replicative helicase.

Authors:  Jillian Chase; Andrew Catalano; Alex J Noble; Edward T Eng; Paul Db Olinares; Kelly Molloy; Danaya Pakotiprapha; Martin Samuels; Brian Chait; Amedee des Georges; David Jeruzalmi
Journal:  Elife       Date:  2018-12-24       Impact factor: 8.140

2.  MCM interference during licensing of DNA replication in Xenopus egg extracts-Possible Role of a C-terminal region of MCM3.

Authors:  Satoru Mimura; Yumiko Kubota; Haruhiko Takisawa
Journal:  Cell Cycle       Date:  2018-01-30       Impact factor: 4.534

Review 3.  Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.

Authors:  Thomas A Kunkel; Peter M J Burgers
Journal:  Bioessays       Date:  2017-08       Impact factor: 4.345

4.  Gene expression profiling and protein-protein interaction analysis reveals the dynamic role of MCM7 in Alzheimer's disorder and breast cancer.

Authors:  Navneeth Sriram; Sunny Mukherjee; Mahesh Kumar Sah
Journal:  3 Biotech       Date:  2022-06-10       Impact factor: 2.893

Review 5.  Imaging cellular responses to antigen tagged DNA damage.

Authors:  Marina A Bellani; Jing Huang; Manikandan Paramasivam; Durga Pokharel; Julia Gichimu; Jing Zhang; Michael M Seidman
Journal:  DNA Repair (Amst)       Date:  2018-08-23

Review 6.  Eukaryotic replication origins: Strength in flexibility.

Authors:  Charanya Kumar; Dirk Remus
Journal:  Nucleus       Date:  2016-05-03       Impact factor: 4.197

7.  Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Authors:  Nimna S Ranatunga; Susan L Forsburg
Journal:  G3 (Bethesda)       Date:  2016-10-13       Impact factor: 3.154

8.  Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication.

Authors:  Takuji Oyama; Sonoko Ishino; Tsuyoshi Shirai; Takeshi Yamagami; Mariko Nagata; Hiromi Ogino; Masami Kusunoki; Yoshizumi Ishino
Journal:  Nucleic Acids Res       Date:  2016-09-05       Impact factor: 16.971

9.  Cryo-EM structure of a licensed DNA replication origin.

Authors:  Ferdos Abid Ali; Max E Douglas; Julia Locke; Valerie E Pye; Andrea Nans; John F X Diffley; Alessandro Costa
Journal:  Nat Commun       Date:  2017-12-21       Impact factor: 14.919

10.  Structure of the active form of human origin recognition complex and its ATPase motor module.

Authors:  Ante Tocilj; Kin Fan On; Zuanning Yuan; Jingchuan Sun; Elad Elkayam; Huilin Li; Bruce Stillman; Leemor Joshua-Tor
Journal:  Elife       Date:  2017-01-23       Impact factor: 8.140
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