Fabiano Svolacchia1, Francesco De Francesco2, Letizia Trovato3, Antonio Graziano3,4, Giuseppe A Ferraro2. 1. Centre of Nanoscience, Mavi Sud, Aprilia, Italy. 2. Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy. 3. Human Brain Wave srl, Turin, Italy. 4. SHRO - Temple University of Philadelphia, Philadelphia, PA, USA.
Abstract
BACKGROUND: Pathological scars occur following injuries and are often considered esthetically unattractive. Several strategies have been attempted to improve these types of scars using both surgical and nonsurgical methods. The most common treatments include cryotherapy, intralesional corticosteroid injections, 5-fluorouracil, bleomycin, interferon, and verapamil. AIMS: In this study, we aim to investigate the effectiveness of dermal autologous micrografts in the treatment of pathological scars resulting from burns, trauma, or any iatrogenic source. METHODS: We used a new clinical practice called Rigenera Protocol to obtain autologous micrografts which were in turn injectable in the patients. RESULTS: A significant improvement was observed in appearance and texture of the exaggerated scars in all cases following already 4 months of autologous micrograft treatment We have also shown that these micrografts are composed of mesenchymal stem cells and in addition, histological evaluation verified restoration of the structural layers immediately below the epidermis and a horizontal realignment of collagen fibers in the papillary dermis. CONCLUSION: Our results clearly demonstrate the optimal outcomes obtained following treatment with dermal micrografts on exaggerated scars with different etiologies. However, further studies are required to confirm the efficacy of this new technique.
BACKGROUND: Pathological scars occur following injuries and are often considered esthetically unattractive. Several strategies have been attempted to improve these types of scars using both surgical and nonsurgical methods. The most common treatments include cryotherapy, intralesional corticosteroid injections, 5-fluorouracil, bleomycin, interferon, and verapamil. AIMS: In this study, we aim to investigate the effectiveness of dermal autologous micrografts in the treatment of pathological scars resulting from burns, trauma, or any iatrogenic source. METHODS: We used a new clinical practice called Rigenera Protocol to obtain autologous micrografts which were in turn injectable in the patients. RESULTS: A significant improvement was observed in appearance and texture of the exaggerated scars in all cases following already 4 months of autologous micrograft treatment We have also shown that these micrografts are composed of mesenchymal stem cells and in addition, histological evaluation verified restoration of the structural layers immediately below the epidermis and a horizontal realignment of collagen fibers in the papillary dermis. CONCLUSION: Our results clearly demonstrate the optimal outcomes obtained following treatment with dermal micrografts on exaggerated scars with different etiologies. However, further studies are required to confirm the efficacy of this new technique.
Authors: Francesco De Francesco; Antonio Graziano; Letizia Trovato; Gabriele Ceccarelli; Maurizio Romano; Marco Marcarelli; Gabriella Maria Cusella De Angelis; Umberto Cillo; Michele Riccio; Giuseppe Andrea Ferraro Journal: Stem Cell Rev Rep Date: 2017-02 Impact factor: 5.739
Authors: Elena Dai Prè; Alice Busato; Silvia Mannucci; Federica Vurro; Francesco De Francesco; Valentina Riccio; Samantha Solito; Reetuparna Biswas; Paolo Bernardi; Michele Riccio; Andrea Sbarbati Journal: Int J Mol Sci Date: 2020-04-27 Impact factor: 5.923
Authors: Marco Viganò; Irene Tessaro; Letizia Trovato; Alessandra Colombini; Marco Scala; Alberto Magi; Andrea Toto; Giuseppe Peretti; Laura de Girolamo Journal: J Orthop Surg Res Date: 2018-11-06 Impact factor: 2.359
Authors: Ruggero Rodriguez Y Baena; Riccardo D'Aquino; Antonio Graziano; Letizia Trovato; Antonio C Aloise; Gabriele Ceccarelli; Gabriella Cusella; André A Pelegrine; Saturnino M Lupi Journal: Front Cell Dev Biol Date: 2017-09-27
Authors: Marco Mario Tresoldi; Antonio Graziano; Alberto Malovini; Angela Faga; Giovanni Nicoletti Journal: Stem Cells Int Date: 2019-09-08 Impact factor: 5.443