Literature DB >> 32211214

A case report on the effect of micrografting in the healing of chronic and complex burn wounds.

Alessandro Andreone1, Daan de Hollander2.   

Abstract

Different approaches can be used to repair extensive burn injury and chronic wounds, including full and split thickness skin grafts, temporising matrices and scaffolds, and composite cultured skin products. The use of non-cultured or autologous skin cells suspension in chronic burn is well established, but despite this no significant literature has been realized. The Rigenera micrografting technology is an innovative technique allowing to obtain a suspension of autologous micrografts that can be applied over the wounds in a combined methodology specifically developed and based on the both injections of the wound edges and spraying over the wound bed of this suspension. A black male patient with open wounds on the back already treated with a traditional split skin graft, present a 10% of wounds not healing. Then, the patient was treated with micrografts suspension obtained by mechanical disaggregation of small split skin biopsies using the Rigeneracons medical device. Micrografts were directly injected and sprayed in the wounds. The combination of injection and sprayed micrografts solution over the wounds achieved full closure over 10% over a period of 6 months. The follow up more than 2 years showed stable wounds with no breakdown in the epidermis. The final cosmetic and functional results obtained with micrografting on chronic burn wounds is a valid alternative when all the other options cannot provide wound closure. IJBT
Copyright © 2020.

Entities:  

Keywords:  Micrografts; autologous; burns; chronic; non-healing wounds

Year:  2020        PMID: 32211214      PMCID: PMC7076320     

Source DB:  PubMed          Journal:  Int J Burns Trauma        ISSN: 2160-2026


  22 in total

Review 1.  Complex wounds and their management.

Authors:  Habeeba Park; Carol Copeland; Sharon Henry; Adrian Barbul
Journal:  Surg Clin North Am       Date:  2010-12       Impact factor: 2.741

2.  An innovative regenerative treatment of scars with dermal micrografts.

Authors:  Fabiano Svolacchia; Francesco De Francesco; Letizia Trovato; Antonio Graziano; Giuseppe A Ferraro
Journal:  J Cosmet Dermatol       Date:  2016-01-30       Impact factor: 2.696

3.  Sprayed cultured autologous keratinocytes used alone or in combination with meshed autografts to accelerate wound closure in difficult-to-heal burns patients.

Authors:  S Elizabeth James; Simon Booth; Baljit Dheansa; Dawn J Mann; Michael J Reid; Rostislav V Shevchenko; Philip M Gilbert
Journal:  Burns       Date:  2009-03-20       Impact factor: 2.744

4.  Metalloproteinases in chronic and acute wounds: A systematic review and meta-analysis.

Authors:  Aroa Tardáguila-García; Esther García-Morales; Josep M García-Alamino; Francisco Javier Álvaro-Afonso; Raúl Juan Molines-Barroso; José Luis Lázaro-Martínez
Journal:  Wound Repair Regen       Date:  2019-03-27       Impact factor: 3.617

5.  Micrografting chronic lower extremity ulcers with mechanically disaggregated skin using a micrograft preparation system.

Authors:  Rosario Miranda; Eleonora Farina; Michele A Farina
Journal:  J Wound Care       Date:  2018-02-02       Impact factor: 2.072

6.  [Keloids on dark skin: a consecutive series of 456 cases].

Authors:  G H Yedomon; H Adegbidi; F Atadokpede; F Akpadjan; E J Mouto; F do Ango-Padonou
Journal:  Med Sante Trop       Date:  2012 Jul-Sep

7.  Progress report for intractable ulcer and osteomyelitis cases using autologous micrografts.

Authors:  Miyuki Uehara; Fumiaki Shimizu
Journal:  SAGE Open Med Case Rep       Date:  2019-05-06

8.  A Retrospective Study on the Use of Dermis Micrografts in Platelet-Rich Fibrin for the Resurfacing of Massive and Chronic Full-Thickness Burns.

Authors:  Alessandro Andreone; Daan den Hollander
Journal:  Stem Cells Int       Date:  2019-09-15       Impact factor: 5.443

Review 9.  Surgical complications and their impact on patients' psychosocial well-being: a systematic review and meta-analysis.

Authors:  Anna Pinto; Omar Faiz; Rachel Davis; Alex Almoudaris; Charles Vincent
Journal:  BMJ Open       Date:  2016-02-16       Impact factor: 2.692

10.  Autologous micrograft accelerates endogenous wound healing response through ERK-induced cell migration.

Authors:  Frederic Lluis; Maurilio Sampaolesi; Martina Balli; Francesca Vitali; Adrian Janiszewski; Ellen Caluwé; Alvaro Cortés-Calabuig; Sebastien Carpentier; Robin Duelen; Flavio Ronzoni; Lukas Marcelis; Francesca Maria Bosisio; Riccardo Bellazzi; Aernout Luttun; Maria G Cusella De Angelis; Gabriele Ceccarelli
Journal:  Cell Death Differ       Date:  2019-10-25       Impact factor: 15.828

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  1 in total

1.  Analysis of the Effect of Wound-Edge Microgranular Skin Grafting in the Treatment of Various Small Wounds.

Authors:  Tiannan Chen; Yuesen Lin; Chengshuo Cui; Fangfang Zhang; Tingting Su; Kaiyu Guo; Jialin Hu
Journal:  Clin Cosmet Investig Dermatol       Date:  2022-05-31
  1 in total

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