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Literature DB >> 26823830

Expression of phosphorylated Akt and hTERT is associated with prognosis of epithelial ovarian carcinoma.

Yoo-Kyung Lee¹, Hyun Hoon Chung², Jae Weon Kim², Yong-Sang Song², Noh-Hyun Park².

Abstract

Activation of human telomere reverse transcriptase (hTERT) is associated with the tumorigenic role of Akt. We aimed to evaluate the significance of Akt phosphorylation and hTERT expression on the prognosis of epithelial ovarian cancer (EOC). Between 2005 and 2012, 92 EOC patients treated at the Seoul National University Hospital were included in this study. Paraffin-embedded sections from the tumors of EOC patients were stained with anti-hTERT and anti-phosphorylated Akt (pAkt) antibodies. Correlations of pAkt and hTERT expression with the clinicopathological factors were analyzed using SPSS software, version 17.0 (IBM, Chicago, IL, USA). In 92 EOC tissues, pAkt and hTERT were not associated with any clinicopathological factors. However, the disease-free survival rate of patients exhibiting coexpression of pAkt and hTERT was poor compared with that of the other patients (P = 0.013). Coexpression of pAkt and hTERT is a poor prognostic marker for EOC.

Entities: Chemical Disease Gene Species

Keywords: AKT; Ovarian neoplasm; hTERT; prognosis

Mesh：

Substances：

Year: 2015 PMID： 26823830 PMCID： PMC4713616

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

23 in total

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Authors: Munmun Rahman; Kentaro Nakayama; Mohammed Tanjimur Rahman; Naomi Nakayama; Masako Ishikawa; Atsuko Katagiri; Kouji Iida; Satoru Nakayama; Yoshiro Otsuki; Ie-Ming Shih; Kohji Miyazaki
Journal: Hum Pathol Date: 2012-06-15 Impact factor: 3.466

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Authors: Wei Jia; Bin Chang; Lili Sun; Huimin Zhu; Lijuan Pang; Lin Tao; Hong Zou; Jinze Du; Yuling Dong; Yan Qi; Jinfang Jiang; Weihua Liang; Feng Li; Xia Zhao
Journal: Int J Clin Exp Pathol Date: 2014-08-15

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Authors: Robert J Kurman; Ie-Ming Shih
Journal: Hum Pathol Date: 2011-07 Impact factor: 3.466

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Authors: Roel G W Verhaak; Pablo Tamayo; Ji-Yeon Yang; Diana Hubbard; Hailei Zhang; Chad J Creighton; Sian Fereday; Michael Lawrence; Scott L Carter; Craig H Mermel; Aleksandar D Kostic; Dariush Etemadmoghadam; Gordon Saksena; Kristian Cibulskis; Sekhar Duraisamy; Keren Levanon; Carrie Sougnez; Aviad Tsherniak; Sebastian Gomez; Robert Onofrio; Stacey Gabriel; Lynda Chin; Nianxiang Zhang; Paul T Spellman; Yiqun Zhang; Rehan Akbani; Katherine A Hoadley; Ari Kahn; Martin Köbel; David Huntsman; Robert A Soslow; Anna Defazio; Michael J Birrer; Joe W Gray; John N Weinstein; David D Bowtell; Ronny Drapkin; Jill P Mesirov; Gad Getz; Douglas A Levine; Matthew Meyerson
Journal: J Clin Invest Date: 2012-12-21 Impact factor: 14.808

Review 6. Human telomerase and its regulation.

Authors: Yu-Sheng Cong; Woodring E Wright; Jerry W Shay
Journal: Microbiol Mol Biol Rev Date: 2002-09 Impact factor: 11.056

7. Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.

Authors: Akiko Sangawa; Michiko Shintani; Naoki Yamao; Shingo Kamoshida
Journal: Int J Clin Exp Pathol Date: 2014-05-15

8. AKT activation and telomerase reverse transcriptase expression are concurrently associated with prognosis of gastric cancer.

Authors: Takamitsu Sasaki; Hiroki Kuniyasu; Yi Luo; Misaho Kitayoshi; Eriko Tanabe; Daisuke Kato; Satoshi Shinya; Kiyomu Fujii; Hitoshi Ohmori; Yuichi Yamashita
Journal: Pathobiology Date: 2013-08-21 Impact factor: 4.342

9. Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors.

Authors: Hatice Ozer; Goncaimir Yenicesu; Sema Arici; Meral Cetin; Ersin Tuncer; Ali Cetin
Journal: Diagn Pathol Date: 2012-09-20 Impact factor: 2.644

Expression of phosphorylated Akt and hTERT is associated with prognosis of epithelial ovarian carcinoma.

Review 1. Telomerase and cancer.

2. Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.

3. REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer.

Review 4. Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm.

5. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.

Review 6. Human telomerase and its regulation.

7. Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.

8. AKT activation and telomerase reverse transcriptase expression are concurrently associated with prognosis of gastric cancer.

9. Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors.

Review 10. The potential role of Akt phosphorylation in human cancers.

1. Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties.

2. hERG1 is involved in the pathophysiological process and inhibited by berberine in SKOV3 cells.

Review 3. Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer.

4. ShRNA-mediated silencing of hTERT promote apoptosis and senescence in human ovarian cancer cells.