Literature DB >> 11257099

Telomerase and cancer.

J W Shay1, Y Zou, E Hiyama, W E Wright.   

Abstract

Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells. Over the past few years there has been significant progress in identifying the components of the telomerase holoenzyme complex and the proteins that associate with telomeres, in order to elucidate mechanisms of telomere length regulation. This review covers recent advances in the field including the use of telomerase in cancer diagnostics and an overview of anti-telomerase cancer therapeutic approaches.

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Year:  2001        PMID： 11257099     DOI： 10.1093/hmg/10.7.677

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  117 in total

1.  Tiny telomere DNA.

Authors:  Jinsong Ren; Xiaogang Qu; John O Trent; Jonathan B Chaires
Journal:  Nucleic Acids Res       Date:  2002-06-01       Impact factor: 16.971

Review 2.  Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.

Authors:  J Fajkus; M Simícková; J Maláska
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2002-04-29       Impact factor: 6.237

3.  In silico evaluation of TERT inhibition by anticancer drugs.

Authors:  Porika Mahendar; Kalam Sirisha; Umasankar Kulandaivelu; Prakhya Laxmi Jaya Shankar; Tippani Radhika; Abbagani Sadanandam
Journal:  J Mol Model       Date:  2012-06-06       Impact factor: 1.810

4.  Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7.

Authors:  H R McMurray; D J McCance
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

5.  Altered mRNA expression of telomere-associated genes in monoclonal gammopathy of undetermined significance and multiple myeloma.

Authors:  Julieta Panero; Jorge Arbelbide; Dorotea Beatriz Fantl; Hernán García Rivello; Dana Kohan; Irma Slavutsky
Journal:  Mol Med       Date:  2010-07-14       Impact factor: 6.354

6.  History of the Baylor Charles A. Sammons Cancer Center.

Authors:  Marvin J Stone; Billie E Aronoff; W Phil Evans; Joseph W Fay; Z H Lieberman; Carolyn M Matthews; George J Race; R Pickett Scruggs; C Allen Stringer
Journal:  Proc (Bayl Univ Med Cent)       Date:  2003-01

7.  TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements.

Authors:  Hong-Yan Du; Elena Pumbo; Jennifer Ivanovich; Ping An; Richard T Maziarz; Ulrike M Reiss; Deborah Chirnomas; Akiko Shimamura; Adrianna Vlachos; Jeffrey M Lipton; Rakesh K Goyal; Frederick Goldman; David B Wilson; Philip J Mason; Monica Bessler
Journal:  Blood       Date:  2008-10-17       Impact factor: 22.113

8.  RNA interference mediated downregulation of human telomerase reverse transcriptase (hTERT) in LN18 cells.

Authors:  Ch Lavanya; M K Sibin; M M Srinivas Bharath; M Jeru Manoj; Manjunatha M Venkataswamy; Dhananjaya I Bhat; K V L Narasinga Rao; G K Chetan
Journal:  Cytotechnology       Date:  2016-10-18       Impact factor: 2.058

9.  Inhibition of telomerase by linear-chain fatty acids: a structural analysis.

Authors:  Masako Oda; Takamasa Ueno; Nobuyuki Kasai; Hirotada Takahashi; Hiromi Yoshida; Fumio Sugawara; Kengo Sakaguchi; Hideya Hayashi; Yoshiyuki Mizushina
Journal:  Biochem J       Date:  2002-10-15       Impact factor: 3.857

10.  Comparison of Periodontal Ligament Cell Lines with Adenovirus- and Lentivirus-Mediated Human Telomerase Reverse Transcription Expression.

Authors:  Guijun Sun; Yang Yang; Xiaoyan Lu; Qing Liu; Shengrong Wu; Jiajia Jin; Zixiao Huang; Xiangyi He
Journal:  Hum Gene Ther Methods       Date:  2019-02-28       Impact factor: 2.396
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