| Literature DB >> 26823525 |
Ying Han1, Kristin A Rand1, Dennis J Hazelett1, Sue A Ingles1, Rick A Kittles1, Sara S Strom1, Benjamin A Rybicki1, Barbara Nemesure1, William B Isaacs1, Janet L Stanford1, Wei Zheng1, Fredrick R Schumacher1, Sonja I Berndt1, Zhaoming Wang1, Jianfeng Xu1, Nadin Rohland1, David Reich1, Arti Tandon1, Bogdan Pasaniuc1, Alex Allen1, Dominique Quinque1, Swapan Mallick1, Dimple Notani1, Michael G Rosenfeld1, Ranveer Singh Jayani1, Suzanne Kolb1, Susan M Gapstur1, Victoria L Stevens1, Curtis A Pettaway1, Edward D Yeboah1, Yao Tettey1, Richard B Biritwum1, Andrew A Adjei1, Evelyn Tay1, Ann Truelove1, Shelley Niwa1, Anand P Chokkalingam1, Esther M John1, Adam B Murphy1, Lisa B Signorello1, John Carpten1, M Cristina Leske1, Suh-Yuh Wu1, Anslem J M Hennis1, Christine Neslund-Dudas1, Ann W Hsing1, Lisa Chu1, Phyllis J Goodman1, Eric A Klein1, S Lilly Zheng1, John S Witte1, Graham Casey1, Alex Lubwama1, Loreall C Pooler1, Xin Sheng1, Gerhard A Coetzee1, Michael B Cook1, Stephen J Chanock1, Daniel O Stram1, Stephen Watya1, William J Blot1, David V Conti1, Brian E Henderson1, Christopher A Haiman1.
Abstract
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00×10(-8), all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38×10(-40); rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04×10(-27); and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39×10(-13)). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.Entities:
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Year: 2016 PMID： 26823525 PMCID： PMC4948565 DOI： 10.1093/jnci/djv431
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506