| Literature DB >> 20453196 |
Nasim Ahmadiyeh1, Mark M Pomerantz, Chiara Grisanzio, Paula Herman, Li Jia, Vanessa Almendro, Housheng Hansen He, Myles Brown, X Shirley Liu, Matt Davis, Jennifer L Caswell, Christine A Beckwith, Adam Hills, Laura Macconaill, Gerhard A Coetzee, Meredith M Regan, Matthew L Freedman.
Abstract
The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.Entities:
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Year: 2010 PMID： 20453196 PMCID： PMC2906844 DOI： 10.1073/pnas.0910668107
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205