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Literature DB >> 26822576

The kinome 'at large' in cancer.

Emmy D G Fleuren¹, Luxi Zhang^2,3,4, Jianmin Wu⁵, Roger J Daly^2,3.

Abstract

Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome 'at large' in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.

Entities: Disease Species

Mesh：

Substances：

Year: 2016 PMID： 26822576 DOI： 10.1038/nrc.2015.18

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

116 in total

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Journal: Neoplasia Date: 2013-12 Impact factor: 5.715

2. RNAi screening of the kinome with cytarabine in leukemias.

Authors: Raoul Tibes; James M Bogenberger; Leena Chaudhuri; R Tanner Hagelstrom; Donald Chow; Megan E Buechel; Irma M Gonzales; Tim Demuth; James Slack; Ruben A Mesa; Esteban Braggio; Hongwei H Yin; Shilpi Arora; David O Azorsa
Journal: Blood Date: 2012-01-20 Impact factor: 22.113

3. Principles and strategies for developing network models in cancer.

Authors: Dana Pe'er; Nir Hacohen
Journal: Cell Date: 2011-03-18 Impact factor: 41.582

4. Integrated genomic characterization of papillary thyroid carcinoma.

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Journal: Cell Date: 2014-10-23 Impact factor: 41.582

5. Kinase requirements in human cells: I. Comparing kinase requirements across various cell types.

Authors: Dorre A Grueneberg; Sebastien Degot; Joseph Pearlberg; Wenliang Li; Joan E Davies; Amy Baldwin; Wilson Endege; John Doench; Jacqueline Sawyer; Yanhui Hu; Frederick Boyce; Jun Xian; Karl Munger; Ed Harlow
Journal: Proc Natl Acad Sci U S A Date: 2008-10-23 Impact factor: 11.205

6. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

Authors: Dalibor Blazek; Jiri Kohoutek; Koen Bartholomeeusen; Eric Johansen; Petra Hulinkova; Zeping Luo; Peter Cimermancic; Jernej Ule; B Matija Peterlin
Journal: Genes Dev Date: 2011-10-15 Impact factor: 11.361

7. NLK is a novel therapeutic target for PTEN deficient tumour cells.

Authors: Ana M Mendes-Pereira; Christopher J Lord; Alan Ashworth
Journal: PLoS One Date: 2012-10-29 Impact factor: 3.240

8. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

Authors: Cory M Johannessen; Jesse S Boehm; So Young Kim; Sapana R Thomas; Leslie Wardwell; Laura A Johnson; Caroline M Emery; Nicolas Stransky; Alexandria P Cogdill; Jordi Barretina; Giordano Caponigro; Haley Hieronymus; Ryan R Murray; Kourosh Salehi-Ashtiani; David E Hill; Marc Vidal; Jean J Zhao; Xiaoping Yang; Ozan Alkan; Sungjoon Kim; Jennifer L Harris; Christopher J Wilson; Vic E Myer; Peter M Finan; David E Root; Thomas M Roberts; Todd Golub; Keith T Flaherty; Reinhard Dummer; Barbara L Weber; William R Sellers; Robert Schlegel; Jennifer A Wargo; William C Hahn; Levi A Garraway
Journal: Nature Date: 2010-11-24 Impact factor: 49.962

9. Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.

Authors: Kingsley M Ekumi; Hana Paculova; Tina Lenasi; Vendula Pospichalova; Christian A Bösken; Jana Rybarikova; Vitezslav Bryja; Matthias Geyer; Dalibor Blazek; Matjaz Barboric
Journal: Nucleic Acids Res Date: 2015-02-20 Impact factor: 16.971

10. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

Authors: Ailan Guo; Hongbo Gu; Jing Zhou; Daniel Mulhern; Yi Wang; Kimberly A Lee; Vicky Yang; Mike Aguiar; Jon Kornhauser; Xiaoying Jia; Jianmin Ren; Sean A Beausoleil; Jeffrey C Silva; Vidyasiri Vemulapalli; Mark T Bedford; Michael J Comb
Journal: Mol Cell Proteomics Date: 2013-10-15 Impact factor: 5.911

94 in total

1. Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta.

Authors: Agnes Czikora; Satyabrata Pany; Youngki You; Amandeep S Saini; Nancy E Lewin; Gary A Mitchell; Adelle Abramovitz; Noemi Kedei; Peter M Blumberg; Joydip Das
Journal: Biochim Biophys Acta Biomembr Date: 2018-01-06 Impact factor: 3.747

2. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.

Authors: Fleur M Ferguson; Zainab M Doctor; Scott B Ficarro; Christopher M Browne; Jarrod A Marto; Jared L Johnson; Tomer M Yaron; Lewis C Cantley; Nam Doo Kim; Taebo Sim; Matthew J Berberich; Marian Kalocsay; Peter K Sorger; Nathanael S Gray
Journal: Cell Chem Biol Date: 2019-03-28 Impact factor: 8.116

3. Leveraging Atropisomerism to Obtain a Selective Inhibitor of RET Kinase with Secondary Activities toward EGFR Mutants.

Authors: Sean T Toenjes; Valeria Garcia; Sean M Maddox; Gregory A Dawson; Maria A Ortiz; F Javier Piedrafita; Jeffrey L Gustafson
Journal: ACS Chem Biol Date: 2019-08-29 Impact factor: 5.100

4. Exposure time versus cytotoxicity for anticancer agents.

Authors: David M Evans; Jianwen Fang; Thomas Silvers; Rene Delosh; Julie Laudeman; Chad Ogle; Russell Reinhart; Michael Selby; Lori Bowles; John Connelly; Erik Harris; Julia Krushkal; Larry Rubinstein; James H Doroshow; Beverly A Teicher
Journal: Cancer Chemother Pharmacol Date: 2019-05-17 Impact factor: 3.333

5. Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

Authors: Fleur M Ferguson; Zainab M Doctor; Scott B Ficarro; Jarrod A Marto; Nam Doo Kim; Taebo Sim; Nathanael S Gray
Journal: Bioorg Med Chem Lett Date: 2019-05-23 Impact factor: 2.823

6. PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact.

Authors: Fuyi Li; Cunshuo Fan; Tatiana T Marquez-Lago; André Leier; Jerico Revote; Cangzhi Jia; Yan Zhu; A Ian Smith; Geoffrey I Webb; Quanzhong Liu; Leyi Wei; Jian Li; Jiangning Song
Journal: Brief Bioinform Date: 2020-05-21 Impact factor: 11.622