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Literature DB >> 26819813

Retinal safety of near infrared radiation in photovoltaic restoration of sight.

H Lorach¹, J Wang¹, D Y Lee², R Dalal³, P Huie¹, D Palanker¹.

Abstract

Photovoltaic restoration of sight requires intense near-infrared light to effectively stimulate retinal neurons. We assess the retinal safety of such radiation with and without the retinal implant. Retinal damage threshold was determined in pigmented rabbits exposed to 880nm laser radiation. The 50% probability (ED50) of retinal damage during 100s exposures with 1.2mm diameter beam occurred at 175mW, corresponding to a modeled temperature rise of 12.5°C. With the implant, the same temperature was reached at 78mW, close to the experimental ED50 of 71mW. In typical use conditions, the retinal temperature rise is not expected to exceed 0.43°C, well within the safety limits for chronic use.

Entities: Disease Species

Keywords: (170.0170) Medical optics and biotechnology; (170.4470) Ophthalmology

Year: 2015 PMID： 26819813 PMCID： PMC4722897 DOI： 10.1364/BOE.7.000013

Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.732

21 in total

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Authors: Gholam A Peyman; Mahmoud Genaidy; Shin Yoneya; Gamze Men; Fatemah Ghahramani; Po-Cheng Kuo; Yanno Bezerra; Yoko Nishiyama-Ito; Andrew A Moshfeghi
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Journal: Lasers Surg Med Date: 2013-09 Impact factor: 4.025

12 in total

1. Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation.

Authors: Elton Ho; Richard Smith; Georges Goetz; Xin Lei; Ludwig Galambos; Theodore I Kamins; James Harris; Keith Mathieson; Daniel Palanker; Alexander Sher
Journal: J Neurophysiol Date: 2017-10-18 Impact factor: 2.714

2. Vertically integrated photo junction-field-effect transistor pixels for retinal prosthesis.

Authors: Samir Damle; Yu-Hsin Liu; Shaurya Arya; Nicholas W Oesch; Yu-Hwa Lo
Journal: Biomed Opt Express Date: 2019-12-04 Impact factor: 3.732

3. Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration.

Authors: Daniel Palanker; Yannick Le Mer; Saddek Mohand-Said; Mahiul Muqit; Jose A Sahel
Journal: Ophthalmology Date: 2020-02-25 Impact factor: 12.079

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5. Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons.

Authors: Thomas Flores; Xin Lei; Tiffany Huang; Henri Lorach; Roopa Dalal; Ludwig Galambos; Theodore Kamins; Keith Mathieson; Daniel Palanker
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Journal: Nat Commun Date: 2018-03-08 Impact factor: 14.919