Rajesh Bhat Uppoor1, Aparna Rajesh2, Mukund Prathivadibhayankaram Srinivasan3, Bhaskaran Unnikrishnan4, Ramesh Holla5. 1. Assistant Professor, Department of Cardiology, Kasturba Medical College (Manipal University) , Mangalore, Karnataka, India . 2. Associate Professor, Department of Obstetrics and Gynaecology, K. S. Hegde Medical Academy , Mangalore . 3. PhD Research Scholar, Department of Internal Medicine, Kasturba Medical College (Manipal University) , Mangalore, Karnataka, India . 4. Professor, Department of Community Medicine, Kasturba Medical College (Manipal University) Mangalore, Karnataka, India . 5. Assistant Professor, Department of Community Medicine, Kasturba Medical College (Manipal University) , Mangalore, Karnataka, India .
Abstract
INTRODUCTION: Coronary Artery Disease are on the rise in the general population and is the leading cause of death in both men and women. The impact of CAD is underappreciated in younger women when compared to men. Women have unique risk factors for CAD and postmenopausal women are at higher risk of developing CAD when compared to normal menstruating women. AIM: The aim of our study was to find out the difference in oxidative stress levels between obese postmenopausal women and normal menstruating women, also to compare the same in normal weight postmenopausal women. MATERIALS AND METHODS: Thirty one normal and 29 obese postmenopausal women with age more than 45 years who visited obstetrics and gynaecology outpatient department for general clinical evaluation at a tertiary care centre were recruited in this cross-sectional study. Thirty normal menstruating women were compared. Anthropometric measurements were recorded and the body mass index was calculated. Serum Malondialdehyde and superoxide dismutase was measured using a spectrophotometer. RESULTS: There was a significant difference in mean MDA levels in postmenopausal women (1.477 ± 0.359) when compared to normal menstruating women (0.666 ± 0.302) (p < 0.01). There was no significant difference in mean SOD levels in postmenopausal women (2.836 ± 0.899) when compared to normal menstruating women (2.986 ± 0.686) (p > 0.05). Also, there was a significant increase between mean MDA levels in obese postmenopausal women (2.48 ± 0.52) when compared to normal weight postmenopausal women (1.65 ± 0.36) (p < 0.01). There was a significant difference between mean SOD levels in obese postmenopausal women (1.36 ± 0.96) and normal weight postmenopausal women (2.56 ± 1.03) (p < 0.01). CONCLUSION: The oxidative stress was higher in obese postmenopausal women when compared to normal weight postmenopausal women and normal menstruating women.
INTRODUCTION: Coronary Artery Disease are on the rise in the general population and is the leading cause of death in both men and women. The impact of CAD is underappreciated in younger women when compared to men. Women have unique risk factors for CAD and postmenopausal women are at higher risk of developing CAD when compared to normal menstruating women. AIM: The aim of our study was to find out the difference in oxidative stress levels between obese postmenopausal women and normal menstruating women, also to compare the same in normal weight postmenopausal women. MATERIALS AND METHODS: Thirty one normal and 29 obese postmenopausal women with age more than 45 years who visited obstetrics and gynaecology outpatient department for general clinical evaluation at a tertiary care centre were recruited in this cross-sectional study. Thirty normal menstruating women were compared. Anthropometric measurements were recorded and the body mass index was calculated. Serum Malondialdehyde and superoxide dismutase was measured using a spectrophotometer. RESULTS: There was a significant difference in mean MDA levels in postmenopausal women (1.477 ± 0.359) when compared to normal menstruating women (0.666 ± 0.302) (p < 0.01). There was no significant difference in mean SOD levels in postmenopausal women (2.836 ± 0.899) when compared to normal menstruating women (2.986 ± 0.686) (p > 0.05). Also, there was a significant increase between mean MDA levels in obese postmenopausal women (2.48 ± 0.52) when compared to normal weight postmenopausal women (1.65 ± 0.36) (p < 0.01). There was a significant difference between mean SOD levels in obese postmenopausal women (1.36 ± 0.96) and normal weight postmenopausal women (2.56 ± 1.03) (p < 0.01). CONCLUSION: The oxidative stress was higher in obese postmenopausal women when compared to normal weight postmenopausal women and normal menstruating women.
Authors: F H EPSTEIN; L D OSTRANDER; B C JOHNSON; M W PAYNE; N S HAYNER; J B KELLER; T FRANCIS Journal: Ann Intern Med Date: 1965-06 Impact factor: 25.391
Authors: Gretchen L Gierach; B Delia Johnson; C Noel Bairey Merz; Sheryl F Kelsey; Vera Bittner; Marian B Olson; Leslee J Shaw; Sunil Mankad; Carl J Pepine; Steven E Reis; William J Rogers; Barry L Sharaf; George Sopko Journal: J Am Coll Cardiol Date: 2006-02-07 Impact factor: 24.094
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