BACKGROUND: Obesity is associated with oxidative stress, and the oxidation of LDL is thought to play a crucial role in the generation of atherosclerotic lesions. OBJECTIVE: The objective was to describe the association of waist circumference (WC) and body mass index (BMI; in kg/m2) with plasma circulating oxidized LDL (ox-LDL) and C-reactive protein (CRP). DESIGN: This cross-sectional study included data for circulating ox-LDL and CRP from a subpopulation of 586 men and women enrolled in a population-based survey conducted in 2000 in Girona, Spain. Multivariate analysis was performed to describe the independent association of WC and BMI with ox-LDL and CRP. RESULTS: Multivariate logistic regression analysis adjusted for lifestyle, educational level, and dietary confounders showed a direct association of WC (quartile distribution) and BMI categories with ox-LDL (P for linear trend = 0.002) and CRP (P for linear trend = 0.004). Subjects in the top quartile of WC and with a BMI > 29.9 were at high risk of elevated circulating concentrations of ox-LDL and CRP. Further adjustment for cardiovascular disease risk factors did not substantially modify these associations. The risk of high ox-LDL concentrations in overweight (BMI = 25.0-29.9) or obese (BMI > or = 30) subjects with a WC < 102 cm (men) or < 88 cm (women) was not significantly different from that in normal-weight subjects with these WCs. In contrast, overweight or obese subjects with higher WCs (WC > or = 102 cm for men and > or = 88 cm for women) were at significantly higher risk of increased ox-LDL. CONCLUSION: High WC was associated with high concentrations of ox-LDL independently of BMI in the study population.
BACKGROUND: Obesity is associated with oxidative stress, and the oxidation of LDL is thought to play a crucial role in the generation of atherosclerotic lesions. OBJECTIVE: The objective was to describe the association of waist circumference (WC) and body mass index (BMI; in kg/m2) with plasma circulating oxidized LDL (ox-LDL) and C-reactive protein (CRP). DESIGN: This cross-sectional study included data for circulating ox-LDL and CRP from a subpopulation of 586 men and women enrolled in a population-based survey conducted in 2000 in Girona, Spain. Multivariate analysis was performed to describe the independent association of WC and BMI with ox-LDL and CRP. RESULTS: Multivariate logistic regression analysis adjusted for lifestyle, educational level, and dietary confounders showed a direct association of WC (quartile distribution) and BMI categories with ox-LDL (P for linear trend = 0.002) and CRP (P for linear trend = 0.004). Subjects in the top quartile of WC and with a BMI > 29.9 were at high risk of elevated circulating concentrations of ox-LDL and CRP. Further adjustment for cardiovascular disease risk factors did not substantially modify these associations. The risk of high ox-LDL concentrations in overweight (BMI = 25.0-29.9) or obese (BMI > or = 30) subjects with a WC < 102 cm (men) or < 88 cm (women) was not significantly different from that in normal-weight subjects with these WCs. In contrast, overweight or obese subjects with higher WCs (WC > or = 102 cm for men and > or = 88 cm for women) were at significantly higher risk of increased ox-LDL. CONCLUSION: High WC was associated with high concentrations of ox-LDL independently of BMI in the study population.
Authors: Christopher Papandreou; Sophia E Schiza; Manolis N Tzatzarakis; Mathaios Kavalakis; Christos M Hatzis; Aristidis M Tsatsakis; Anthony G Kafatos; Nikolaos M Siafakas; Nikolaos E Tzanakis Journal: Sleep Breath Date: 2011-09-15 Impact factor: 2.816
Authors: Christian K Roberts; Mary M Lee; Michael Katiraie; Shannon L Krell; Siddhartha S Angadi; Michael K Chronley; Christopher S Oh; Vicent Ribas; Ryan A Harris; Andrea L Hevener; Daniel M Croymans Journal: Med Sci Sports Exerc Date: 2015-06 Impact factor: 5.411
Authors: Omer T Njajou; Alka M Kanaya; Paul Holvoet; Stephanie Connelly; Elsa S Strotmeyer; Tamara B Harris; Steve R Cummings; Wen-Chi Hsueh Journal: Diabetes Metab Res Rev Date: 2009-11 Impact factor: 4.876
Authors: Justine Beck; Luigi Ferrucci; Kai Sun; Linda P Fried; Ravi Varadhan; Jeremy Walston; Jack M Guralnik; Richard D Semba Journal: Nutrition Date: 2008-06-30 Impact factor: 4.008
Authors: Betsy L Crist; D Lee Alekel; Laura M Ritland; Laura N Hanson; Ulrike Genschel; Manju B Reddy Journal: J Womens Health (Larchmt) Date: 2009-06 Impact factor: 2.681
Authors: Helmut Schröder; Jose Antonio Morales-Molina; Silvia Bermejo; Diego Barral; Eduardo Soler Mándoli; María Grau; Monica Guxens; Elisabet de Jaime Gil; Marisol Domínguez Alvarez; Jaume Marrugat Journal: Eur J Nutr Date: 2007-09-20 Impact factor: 5.614