PURPOSE: To evaluate the effect of corneal cross-linking (CXL) in progressive keratoconus by applying in vivo static and dynamic Scheimpflug analyses. METHODS: In this longitudinal retrospective study, corneal topography and tomography (Pentacam HD) and dynamic Scheimpflug-based biomechanical analyses (CorvisST [CST]) of 24 eyes of 24 patients with progressive keratoconus before and 6 months after CXL were reviewed. New dynamic curve analyses, provided by Oculus Optikgeräte, were performed to analyze corneal dynamics throughout the entire response to the CST air puff impulse. RESULTS: Besides subtle changes of topography and tomography, only the CorvisST predefined parameters peak distance (-0.5 mm) and radius of the intended cornea (+0.5 mm; P < .05) demonstrated statistically significant differences 6 months after CXL. Using new dynamic curve analyses, additional distinct changes of the corneal biomechanical characteristics after CXL were noted. CONCLUSIONS: Published results of corneal biomechanical changes after CXL for progressive keratoconus based on single, predefined CST parameters are inconsistent. The new dynamic curve analyses demonstrate distinct changes of the biomechanical properties of the cornea and might therefore be the next step in understanding in vivo analyses of corneal biomechanics. Copyright 2016, SLACK Incorporated.
PURPOSE: To evaluate the effect of corneal cross-linking (CXL) in progressive keratoconus by applying in vivo static and dynamic Scheimpflug analyses. METHODS: In this longitudinal retrospective study, corneal topography and tomography (Pentacam HD) and dynamic Scheimpflug-based biomechanical analyses (CorvisST [CST]) of 24 eyes of 24 patients with progressive keratoconus before and 6 months after CXL were reviewed. New dynamic curve analyses, provided by Oculus Optikgeräte, were performed to analyze corneal dynamics throughout the entire response to the CST air puff impulse. RESULTS: Besides subtle changes of topography and tomography, only the CorvisST predefined parameters peak distance (-0.5 mm) and radius of the intended cornea (+0.5 mm; P < .05) demonstrated statistically significant differences 6 months after CXL. Using new dynamic curve analyses, additional distinct changes of the corneal biomechanical characteristics after CXL were noted. CONCLUSIONS: Published results of corneal biomechanical changes after CXL for progressive keratoconus based on single, predefined CST parameters are inconsistent. The new dynamic curve analyses demonstrate distinct changes of the biomechanical properties of the cornea and might therefore be the next step in understanding in vivo analyses of corneal biomechanics. Copyright 2016, SLACK Incorporated.
Authors: Yskert von Kodolitsch; Meike Rybczynski; Marina Vogler; Thomas S Mir; Helke Schüler; Kerstin Kutsche; Georg Rosenberger; Christian Detter; Alexander M Bernhardt; Axel Larena-Avellaneda; Tilo Kölbel; E Sebastian Debus; Malte Schroeder; Stephan J Linke; Bettina Fuisting; Barbara Napp; Anna Lena Kammal; Klaus Püschel; Peter Bannas; Boris A Hoffmann; Nele Gessler; Eva Vahle-Hinz; Bärbel Kahl-Nieke; Götz Thomalla; Christina Weiler-Normann; Gunda Ohm; Stefan Neumann; Dieter Benninghoven; Stefan Blankenberg; Reed E Pyeritz Journal: J Multidiscip Healthc Date: 2016-11-03
Authors: Naomi A L O'Brart; David P S O'Brart; Nada H Aldahlawi; Sally Hayes; Keith M Meek Journal: Invest Ophthalmol Vis Sci Date: 2018-02-01 Impact factor: 4.799