Literature DB >> 26807541

Pyrrole: An emerging scaffold for construction of valuable therapeutic agents.

Somnath S Gholap1.   

Abstract

Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs. Due to their inimitable anticancer and anti-tubercular properties, researchers were inspired to develop novel pyrrole derivatives for the treatment of MDR pathogens. In the present review the main target is to focus on the development of pyrrole mimics, with emphasis based on their structure activity relationship (SAR). The present review is being obliging for the future development of pyrrole therapeutics.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Fused pyrroles; N-substituted pyrrole; Natural pyrrole derivatives; Therapeutic agents

Mesh:

Substances:

Year:  2015        PMID: 26807541     DOI: 10.1016/j.ejmech.2015.12.017

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  34 in total

Review 1.  Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation.

Authors:  Alexander Kornienko; James J La Clair
Journal:  Nat Prod Rep       Date:  2017-08-30       Impact factor: 13.423

2.  Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives.

Authors:  Shu-Guang Zhang; Chao-Gen Liang; Yue-Qing Sun; Peng Teng; Jia-Qun Wang; Wei-Hua Zhang
Journal:  Mol Divers       Date:  2019-01-29       Impact factor: 2.943

3.  Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Acyclic α-N-Pyrrolyl/Indolyl Ketones.

Authors:  Remi Lavernhe; Eric J Alexy; Haiming Zhang; Brian M Stoltz
Journal:  Org Lett       Date:  2020-05-18       Impact factor: 6.005

Review 4.  Malononitrile dimer as a privileged reactant in design and skeletal diverse synthesis of heterocyclic motifs.

Authors:  Ahmad Shaabani; Seyyed Emad Hooshmand
Journal:  Mol Divers       Date:  2018-01-03       Impact factor: 2.943

5.  Insecticidal efficacy of six new pyrrole derivatives against four stored-product pests.

Authors:  Maria C Boukouvala; Nickolas G Kavallieratos; Christos G Athanassiou; Giovanni Benelli; Lazaros P Hadjiarapoglou
Journal:  Environ Sci Pollut Res Int       Date:  2019-08-13       Impact factor: 4.223

6.  Revisit to the synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives in lactic acid media as a green solvent and catalyst.

Authors:  Dilek Akbaslar; E Sultan Giray; Oztekin Algul
Journal:  Mol Divers       Date:  2020-09-27       Impact factor: 2.943

Review 7.  Greener organic synthetic methods: Sonochemistry and heterogeneous catalysis promoted multicomponent reactions.

Authors:  Ingrid V Machado; Jhonathan R N Dos Santos; Marcelo A P Januario; Arlene G Corrêa
Journal:  Ultrason Sonochem       Date:  2021-08-05       Impact factor: 7.491

Review 8.  Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018-2021).

Authors:  Ashima Dhiman; Rupam Sharma; Rajesh K Singh
Journal:  Acta Pharm Sin B       Date:  2022-04-01       Impact factor: 14.903

Review 9.  Marine Pyrrole Alkaloids.

Authors:  Kevin Seipp; Leander Geske; Till Opatz
Journal:  Mar Drugs       Date:  2021-09-10       Impact factor: 5.118

10.  Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines.

Authors:  Franz-Lucas Haut; Niklas J Feichtinger; Immanuel Plangger; Lukas A Wein; Mira Müller; Tim-Niclas Streit; Klaus Wurst; Maren Podewitz; Thomas Magauer
Journal:  J Am Chem Soc       Date:  2021-06-09       Impact factor: 15.419

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