Literature DB >> 28808718

Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation.

Alexander Kornienko1, James J La Clair.   

Abstract

Covering: up to June 2017Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.

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Year:  2017        PMID： 28808718      PMCID： PMC5759776          DOI： 10.1039/c7np00024c

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  56 in total

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  12 in total

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6.  Ribose conversion with amino acids into pyrraline platform chemicals - expeditious synthesis of diverse pyrrole-fused alkaloid compounds.

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7.  Semi-synthetic cinnamodial analogues: Structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito Aedes aegypti.

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8.  Enantioselective Total Synthesis of Macfarlandin C, a Spongian Diterpenoid Harboring a Concave-Substituted cis-Dioxabicyclo[3.3.0]octanone Fragment.

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9.  Observation and Kinetic Characterization of Transient Schiff Base Intermediates by CEST NMR Spectroscopy.

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10.  CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism.

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Journal:  Cell Chem Biol       Date:  2021-03-31       Impact factor: 9.039
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