Aya Noro1, Takashi Nakamura2, Toshiko Hirai3, Masayo Haga4, Toyoki Kobayashi5, Akinobu Hayashi6, Yuji Kozuka6, Tokiko Nakai7, Toru Ogura8, Tomoko Ogawa9. 1. Department of Breast Surgery, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. xxxme_heavenly@yahoo.co.jp. 2. Department of Breast Surgery, Nabari City Hospital, Nabari, Mie, Japan. 3. Department of Endoscopy and Ultrasound, Nara Medical University Hospital, Kashihara, Nara, Japan. 4. Department of Radiology, Nara Medical University Hospital, Kashihara, Nara, Japan. 5. Department of Breast Surgery, Nara Medical University Hospital, Kashihara, Nara, Japan. 6. Department of Pathology, Mie University Hospital, Tsu, Mie, Japan. 7. Department of Pathology, Nara Medical University Hospital, Kashihara, Nara, Japan. 8. Center of Development of Clinical Study, Mie University Hospital, Tsu, Mie, Japan. 9. Department of Breast Surgery, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Abstract
PURPOSE: To prospectively evaluate the usefulness of contrast-enhanced ultrasound (CEUS) using parametric imaging for breast cancer in a multicenter study. METHODS: A total of 65 patients with breast cancer were included in this study. CEUS was performed, and still images on peak time (S), accumulated images (A) and parametric images (P) were generated from the raw data. Four blind reviewers ranked the best visible images as first place, and determined second and third place consecutively. We compared the average ranking of each image. The maximal diameter of the tumor determined on ultrasonography and MRI was compared with the corresponding pathological maximal diameter for 48 of the 65 patients. The correlation between the diameter determined by two experts and two beginners was analyzed. RESULTS: The average rank of visibility was as follows: P, 1.44; A, 2.04; and S, 2.52. The correlation between each image and the pathology was as follows: P, r = 0.664; A, r = 0.630; S, r = 0.717; and MRI, r = 0.936. There were no significant differences among the correlation between the experts and beginners in each image. CONCLUSIONS: The use of parametric imaging improves the visibility of CEUS. The maximal diameter of the tumor determined on CEUS correlates substantially with the pathology.
PURPOSE: To prospectively evaluate the usefulness of contrast-enhanced ultrasound (CEUS) using parametric imaging for breast cancer in a multicenter study. METHODS: A total of 65 patients with breast cancer were included in this study. CEUS was performed, and still images on peak time (S), accumulated images (A) and parametric images (P) were generated from the raw data. Four blind reviewers ranked the best visible images as first place, and determined second and third place consecutively. We compared the average ranking of each image. The maximal diameter of the tumor determined on ultrasonography and MRI was compared with the corresponding pathological maximal diameter for 48 of the 65 patients. The correlation between the diameter determined by two experts and two beginners was analyzed. RESULTS: The average rank of visibility was as follows: P, 1.44; A, 2.04; and S, 2.52. The correlation between each image and the pathology was as follows: P, r = 0.664; A, r = 0.630; S, r = 0.717; and MRI, r = 0.936. There were no significant differences among the correlation between the experts and beginners in each image. CONCLUSIONS: The use of parametric imaging improves the visibility of CEUS. The maximal diameter of the tumor determined on CEUS correlates substantially with the pathology.
Entities:
Keywords:
Breast cancer; Contrast-enhanced ultrasound; Parametric image; Sonazoid®; Visibility
Authors: C Boetes; R D Mus; R Holland; J O Barentsz; S P Strijk; T Wobbes; J H Hendriks; S H Ruys Journal: Radiology Date: 1995-12 Impact factor: 11.105
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