Mikael Thinggaard1,2, Matt McGue2,3, Bernard Jeune1,2, Merete Osler1,4, James W Vaupel1,2,5,6, Kaare Christensen1,2,5,7,8. 1. Danish Aging Research Center, University of Southern Denmark, Odense, Denmark. 2. Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark. 3. Department of Psychology, University of Minnesota, Minneapolis, Minnesota. 4. Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark. 5. Max-Planck Odense Center on the Biodemography of Aging, University of Southern Denmark, Odense, Denmark. 6. Max Planck Institute for Demographic Research, Rostock, Germany. 7. Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. 8. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Abstract
OBJECTIVES: To determine whether simple functional indicators are predictors of survival prognosis in very old adults. DESIGN: In-person survey conducted over a 3-month period in 1998; assessment of survival over a 15-year follow-up period. SETTING: Denmark. PARTICIPANTS: All 3,600 Danes born in 1905 and living in Denmark in 1998, were invited to participate regardless of residence and health; 2,262 (63%) participated in the survey: 1,814 (80.2%) in person and 448 (19.8%) through a proxy. MEASUREMENTS: Socioeconomic factors, medications and diseases, activities of daily living, physical performance, cognition, depression symptomatology, self-rated health, and all-cause mortality, evaluated as average remaining lifespan and chance of surviving to 100 years. RESULTS: Men aged 92 to 93 had an overall 6.0% chance of surviving to 100 years, whereas the chance for women was 11.4%. Being able to rise without use of hands increased the chance for men to 11.2% (95% confidence interval (CI)=7.7-14.7) and for women to 22.0% (95% CI=18.9-25.1). When combining this with a Mini-Mental State Examination (MMSE) scores from 28 to 30, the chances were 21.7% (95% CI=11.5-31.9) for men and 34.2% (95% CI=24.8-43.5) for women. CONCLUSION: Chair stand score combined with MMSE score is a quick and easy way to estimate overall chance of survival in very old adults, which is particularly relevant when treatment with potential side effects for nonacute diseases is considered.
OBJECTIVES: To determine whether simple functional indicators are predictors of survival prognosis in very old adults. DESIGN: In-person survey conducted over a 3-month period in 1998; assessment of survival over a 15-year follow-up period. SETTING: Denmark. PARTICIPANTS: All 3,600 Danes born in 1905 and living in Denmark in 1998, were invited to participate regardless of residence and health; 2,262 (63%) participated in the survey: 1,814 (80.2%) in person and 448 (19.8%) through a proxy. MEASUREMENTS: Socioeconomic factors, medications and diseases, activities of daily living, physical performance, cognition, depression symptomatology, self-rated health, and all-cause mortality, evaluated as average remaining lifespan and chance of surviving to 100 years. RESULTS:Men aged 92 to 93 had an overall 6.0% chance of surviving to 100 years, whereas the chance for women was 11.4%. Being able to rise without use of hands increased the chance for men to 11.2% (95% confidence interval (CI)=7.7-14.7) and for women to 22.0% (95% CI=18.9-25.1). When combining this with a Mini-Mental State Examination (MMSE) scores from 28 to 30, the chances were 21.7% (95% CI=11.5-31.9) for men and 34.2% (95% CI=24.8-43.5) for women. CONCLUSION: Chair stand score combined with MMSE score is a quick and easy way to estimate overall chance of survival in very old adults, which is particularly relevant when treatment with potential side effects for nonacute diseases is considered.
Authors: L Decoster; K Van Puyvelde; S Mohile; U Wedding; U Basso; G Colloca; S Rostoft; J Overcash; H Wildiers; C Steer; G Kimmick; R Kanesvaran; A Luciani; C Terret; A Hurria; C Kenis; R Audisio; M Extermann Journal: Ann Oncol Date: 2014-06-16 Impact factor: 32.976
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Authors: Kaare Christensen; Mikael Thinggaard; Anna Oksuzyan; Troels Steenstrup; Karen Andersen-Ranberg; Bernard Jeune; Matt McGue; James W Vaupel Journal: Lancet Date: 2013-07-11 Impact factor: 79.321
Authors: Signe Høi Rasmussen; Karen Andersen-Ranberg; Mikael Thinggaard; Bernard Jeune; Axel Skytthe; Lene Christiansen; James W Vaupel; Matt McGue; Kaare Christensen Journal: Int J Epidemiol Date: 2017-12-01 Impact factor: 7.196
Authors: Jacob K Pedersen; Irma T Elo; Nicole Schupf; Thomas T Perls; Eric Stallard; Anatoliy I Yashin; Kaare Christensen Journal: J Gerontol A Biol Sci Med Sci Date: 2016-08-18 Impact factor: 6.053
Authors: Mikael Thinggaard; Bernard Jeune; Merete Osler; James W Vaupel; Matt McGue; Kaare Christensen Journal: J Gerontol A Biol Sci Med Sci Date: 2020-11-13 Impact factor: 6.053