Literature DB >> 2676060

Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes.

W G Nayler1, J J Liu, S Panagiotopoulos, D J Casley.   

Abstract

The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density of [125I]ET binding sites was reduced (P less than 0.01) without changes in affinity or selectivity.

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Year:  1989        PMID： 2676060      PMCID： PMC1854608          DOI： 10.1111/j.1476-5381.1989.tb12552.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

1.  Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria.

Authors:  T Ishikawa; M Yanagisawa; S Kimura; K Goto; T Masaki
Journal:  Am J Physiol       Date:  1988-10

2.  Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

Authors:  M S Simonson; S Wann; P Mené; G R Dubyak; M Kester; Y Nakazato; J R Sedor; M J Dunn
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

3.  Endothelin has potent inotropic effects in rat atria.

Authors:  J R Hu; R Von Harsdorf; R E Lang
Journal:  Eur J Pharmacol       Date:  1988-12-13       Impact factor: 4.432

4.  Endothelin, a novel vasoconstrictor peptide, as potent bronchoconstrictor.

Authors:  Y Uchida; H Ninomiya; M Saotome; A Nomura; M Ohtsuka; M Yanagisawa; K Goto; T Masaki; S Hasegawa
Journal:  Eur J Pharmacol       Date:  1988-09-13       Impact factor: 4.432

5.  A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Authors:  M Yanagisawa; H Kurihara; S Kimura; Y Tomobe; M Kobayashi; Y Mitsui; Y Yazaki; K Goto; T Masaki
Journal:  Nature       Date:  1988-03-31       Impact factor: 49.962

6.  Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide.

Authors:  T Ishikawa; M Yanagisawa; S Kimura; K Goto; T Masaki
Journal:  Pflugers Arch       Date:  1988-11       Impact factor: 3.657

7.  Dihydropyridine binding sites in aerobically perfused, ischemic, and reperfused rat hearts: effect of temperature and time.

Authors:  X H Gu; J S Dillon; W G Nayler
Journal:  J Cardiovasc Pharmacol       Date:  1988-09       Impact factor: 3.105

8.  Hearts from diabetic rats are more resistant to in vitro ischemia: possible role of altered Ca2+ metabolism.

Authors:  M Tani; J R Neely
Journal:  Circ Res       Date:  1988-05       Impact factor: 17.367

9.  Competitive interaction between endothelin and sarafotoxin: Binding and phosphoinositides hydrolysis in rat atria and brain.

Authors:  I Ambar; Y Kloog; I Schvartz; E Hazum; M Sokolovsky
Journal:  Biochem Biophys Res Commun       Date:  1989-01-16       Impact factor: 3.575

10.  Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols.

Authors:  M Sugiura; T Inagami; G M Hare; J A Johns
Journal:  Biochem Biophys Res Commun       Date:  1989-01-16       Impact factor: 3.575
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  4 in total

1.  The effects of endothelin-1 and NG-nitro-L-arginine methyl ester on regional haemodynamics in conscious rats with streptozotocin-induced diabetes mellitus.

Authors:  R J Kiff; S M Gardiner; A M Compton; T Bennett
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

2.  The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats.

Authors:  N E Cameron; K C Dines; M A Cotter
Journal:  Diabetologia       Date:  1994-12       Impact factor: 10.122

3.  Altered microvascular reactivity to endothelin-1, endothelin-3 and NG-nitro-L-arginine methyl ester in streptozotocin-induced diabetes mellitus.

Authors:  E Lawrence; S D Brain
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

4.  Effects of glucose, insulin or aldose reductase inhibition on responses to endothelin-1 of aortic rings from streptozotocin-induced diabetic rats.

Authors:  W C Hodgson; R G King
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739
  4 in total

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