Literature DB >> 2536275

Competitive interaction between endothelin and sarafotoxin: Binding and phosphoinositides hydrolysis in rat atria and brain.

I Ambar1, Y Kloog, I Schvartz, E Hazum, M Sokolovsky.   

Abstract

Binding studies with the structurally similar vasoconstrictor peptides 125I-endothelin and 125I-sarafotoxin b, the former of mammalian origin and the latter derived from snake venom, reveal their mutually exclusive binding to rat atrium and various regions of the rat brain. In these tissues endothelin, like sarafotoxin, induces phosphoinositide hydrolysis which is in part Ca2+-independent. It is suggested that endothelins and sarafotoxins share common binding sites and mechanisms of action.

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Year:  1989        PMID： 2536275     DOI： 10.1016/s0006-291x(89)80197-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

1.  Endothelin causes contraction of canine and bovine arterial smooth muscle in vitro and in vivo.

Authors:  Y Suzuki; S Satoh; I Ikegaki; T Asano; M Shibuya; K Sugita; K Lederis; O Rorstad
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

Review 2.  Endothelin: a review of its effects and possible mechanisms of action.

Authors:  W Lovenberg; R C Miller
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

3.  Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

Authors:  M W MacCumber; C A Ross; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

4.  Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.

Authors:  M Skolovsky; R Galron; Y Kloog; A Bdolah; F E Indig; S Blumberg; G Fleminger
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

5.  Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

Authors:  M W MacCumber; C A Ross; B M Glaser; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

6.  Pre- and postjunctional actions of endothelin in the rat iris sphincter preparation.

Authors:  M Shinkai; H Tsuruoka; S Wakabayashi; Y Yamamoto; I Takayanagi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-07       Impact factor: 3.000

7.  Sarafotoxin expression in the bronchopulmonary tract: immunohistochemical occurrence and colocalization with endothelins.

Authors:  K A Seldeslagh; J M Lauweryns
Journal:  Histochemistry       Date:  1993-10

8.  Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts.

Authors:  R Plevin; E E MacNulty; S Palmer; M J Wakelam
Journal:  Biochem J       Date:  1991-12-15       Impact factor: 3.857

9.  Endothelium-dependent vascular activities of endothelin-like peptides in the isolated superior mesenteric arterial bed of the rat.

Authors:  S A Douglas; C R Hiley
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

10.  Structure-activity studies on endothelin (16-21), the C-terminal hexapeptide of the endothelins, in the guinea-pig bronchus.

Authors:  P Rovero; R Patacchini; C A Maggi
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739
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