Literature DB >> 2464160

Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide.

T Ishikawa1, M Yanagisawa, S Kimura, K Goto, T Masaki.   

Abstract

Endothelin (ET) is a novel 21-amino-acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, which has a potent vasoconstricting effect. It has been suggested that ET increases Ca2+ influx via a voltage-dependent Ca2+ channel. The purpose of the present study is to investigate the mode of actions of ET on the cardiac automaticity. ET increased the sinoatrial nodal rate in a dose-dependent manner on the isolated right atria of guinea pigs. The positive chronotropic effect of ET was very potent and the ED50 value was 0.4 nM. These results suggest that ET is one of the most potent cardio-acceleratory substances.

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Year:  1988        PMID： 2464160     DOI： 10.1007/bf00581239

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  8 in total

1.  EFFECTS OF CALCIUM ON ISOLATED MAMMALIAN HEART.

Authors:  E SEIFEN; W FLACKE; M H ALPER
Journal:  Am J Physiol       Date:  1964-09

2.  Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria.

Authors:  T Ishikawa; M Yanagisawa; S Kimura; K Goto; T Masaki
Journal:  Am J Physiol       Date:  1988-10

3.  Pharmacological analysis of autonomic innervation of the right atria of rats and guinea pigs: demonstration of nonadrenergic noncholinergic nerves.

Authors:  A Saito; T Ishikawa; T Masaki; S Kimura; K Goto
Journal:  J Pharmacol Exp Ther       Date:  1986-08       Impact factor: 4.030

4.  A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Authors:  M Yanagisawa; H Kurihara; S Kimura; Y Tomobe; M Kobayashi; Y Mitsui; Y Yazaki; K Goto; T Masaki
Journal:  Nature       Date:  1988-03-31       Impact factor: 49.962

5.  Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

Authors:  Y Itoh; M Yanagisawa; S Ohkubo; C Kimura; T Kosaka; A Inoue; N Ishida; Y Mitsui; H Onda; M Fujino
Journal:  FEBS Lett       Date:  1988-04-25       Impact factor: 4.124

Review 6.  Pacemaker currents in mammalian nodal cells.

Authors:  H Irisawa; A Noma
Journal:  J Mol Cell Cardiol       Date:  1984-09       Impact factor: 5.000

7.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

8.  Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or smooth muscle stimulants.

Authors:  M Schramm; G Thomas; R Towart; G Franckowiak
Journal:  Arzneimittelforschung       Date:  1983
  8 in total
  23 in total

1.  Exercise in hypoxic environments: the mechanism remains elusive.

Authors:  John Longhurst
Journal:  J Physiol       Date:  2003-06-13       Impact factor: 5.182

2.  Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway.

Authors:  R A Kelly; H Eid; B K Krämer; M O'Neill; B T Liang; M Reers; T W Smith
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

Review 3.  Endothelin: a review of its effects and possible mechanisms of action.

Authors:  W Lovenberg; R C Miller
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

Review 4.  The clinical potential of endothelin receptor antagonists in cardiovascular medicine.

Authors:  C J Ferro; D J Webb
Journal:  Drugs       Date:  1996-01       Impact factor: 9.546

Review 5.  Endothelin receptor antagonists and cardiovascular diseases of aging.

Authors:  M P Love; J J McMurray
Journal:  Drugs Aging       Date:  2001       Impact factor: 3.923

6.  Inhibition of granulocyte-derived proteases reduces the increase in plasma endothelin associated with myocardial ischemia in the pig.

Authors:  T Tønnessen; A Ilebekk; P A Naess; G Christensen
Journal:  Basic Res Cardiol       Date:  1996 Jul-Aug       Impact factor: 17.165

7.  Endothelin-1 mediated inhibition of the acetylcholine-activated potassium current from rabbit isolated atrial cardiomyocytes.

Authors:  J P Spiers; E J Kelso; B J McDermott; C N Scholfield; B Silke
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

8.  Endothelin receptors in the human coronary artery, ventricle and atrium. A quantitative autoradiographic analysis.

Authors:  W A Bax; A T Bruinvels; R J van Suylen; P R Saxena; D Hoyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-10       Impact factor: 3.000

9.  Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes.

Authors:  W G Nayler; J J Liu; S Panagiotopoulos; D J Casley
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

Review 10.  Cardioprotective signaling by endothelin.

Authors:  Anita Schorlemmer; Michelle L Matter; Ralph V Shohet
Journal:  Trends Cardiovasc Med       Date:  2008-10       Impact factor: 6.677
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