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Literature DB >> 2674938

Codon choice and gene expression: synonymous codons differ in translational accuracy.

Abstract

Ribosomes programmed by different synonymous codons also differ in discriminating among near-cognate aminoacylated tRNAs. In the initial step of the recognition reaction ribosomes programmed by UUC discriminate less well than ribosomes programmed by UUU against ternary complexes containing three types of Leu-tRNA, and ribosomes programmed by CUC discriminate less well than ribosomes programmed by CUU against ternary complexes containing Phe-tRNA. Furthermore, in the proofreading step ribosomes programmed by UUC discriminate less well than ribosomes programmed by UUU against two of three near-cognate Leu-tRNAs, and ribosomes programmed by CUC discriminate less well than ribosomes programmed by CUU against near-cognate Phe-tRNA. The codon-induced change in reaction rate with near-cognate ternary complexes is greater than that with cognate ternary complexes: the most efficient codon is, therefore, the least accurate. Because the efficient, but inaccurate, codon UUC is used preferentially in highly expressed mRNAs of Escherichia coli, maximization of translational accuracy apparently has not been significant in the evolution of this particular biased codon choice in E. coli.

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Year: 1989 PMID： 2674938 PMCID： PMC297955 DOI： 10.1073/pnas.86.18.6888

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. Effect of replacing uridine 33 in yeast tRNAPhe on the reaction with ribosomes.

Authors: D B Dix; W L Wittenberg; O C Uhlenbeck; R C Thompson
Journal: J Biol Chem Date: 1986-08-05 Impact factor: 5.157

2. Mistranslation during phenylalanine starvation.

Authors: J Parker; J Precup
Journal: Mol Gen Genet Date: 1986-07

3. Guanosine 5'-O-(3-thiotriphosphate) as an analog of GTP in protein biosynthesis. The effects of temperature and polycations on the accuracy of initial recognition of aminoacyl-tRNA ternary complexes by ribosomes.

Authors: A M Karim; R C Thompson
Journal: J Biol Chem Date: 1986-03-05 Impact factor: 5.157

4. Variable rate of polypeptide chain elongation for colicins A, E2 and E3.

Authors: S Varenne; M Knibiehler; D Cavard; J Morlon; C Lazdunski
Journal: J Mol Biol Date: 1982-07-25 Impact factor: 5.469

5. Codon usage and mistranslation. In vivo basal level misreading of the MS2 coat protein message.

Authors: J Parker; T C Johnston; P T Borgia; G Holtz; E Remaut; W Fiers
Journal: J Biol Chem Date: 1983-08-25 Impact factor: 5.157

6. Mechanism of codon recognition by transfer RNA and codon-induced tRNA association.

Authors: D Labuda; G Striker; D Porschke
Journal: J Mol Biol Date: 1984-04-25 Impact factor: 5.469

7. Codon choice and gene expression: synonymous codons differ in their ability to direct aminoacylated-transfer RNA binding to ribosomes in vitro.

Authors: L K Thomas; D B Dix; R C Thompson
Journal: Proc Natl Acad Sci U S A Date: 1988-06 Impact factor: 11.205

Review 8. Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes.

Authors: H Grosjean; W Fiers
Journal: Gene Date: 1982-06 Impact factor: 3.688

9. Escherichia coli ribosomes translate in vivo with variable rate.

Authors: S Pedersen
Journal: EMBO J Date: 1984-12-01 Impact factor: 11.598

10. Is there proofreading during polypeptide synthesis?

Authors: T Ruusala; M Ehrenberg; C G Kurland
Journal: EMBO J Date: 1982 Impact factor: 11.598

25 in total

1. The accuracy of codon recognition by polypeptide release factors.

Authors: D V Freistroffer; M Kwiatkowski; R H Buckingham; M Ehrenberg
Journal: Proc Natl Acad Sci U S A Date: 2000-02-29 Impact factor: 11.205

2. Effect of size, quaternary structure and translational error on the static and dynamic heterogeneity of beta-galactosidase and measurement of electrophoretic dynamic heterogeneity.

Authors: Douglas B Craig; Allison M Haslam; Harlyn J Silverstein; Miki Chikamatsu; Elnaz Shadabi; Ellert R Nichols
Journal: Protein J Date: 2010-08 Impact factor: 2.371

Codon choice and gene expression: synonymous codons differ in translational accuracy.

1. Effect of replacing uridine 33 in yeast tRNAPhe on the reaction with ribosomes.

2. Mistranslation during phenylalanine starvation.

3. Guanosine 5'-O-(3-thiotriphosphate) as an analog of GTP in protein biosynthesis. The effects of temperature and polycations on the accuracy of initial recognition of aminoacyl-tRNA ternary complexes by ribosomes.

4. Variable rate of polypeptide chain elongation for colicins A, E2 and E3.

5. Codon usage and mistranslation. In vivo basal level misreading of the MS2 coat protein message.

6. Mechanism of codon recognition by transfer RNA and codon-induced tRNA association.

7. Codon choice and gene expression: synonymous codons differ in their ability to direct aminoacylated-transfer RNA binding to ribosomes in vitro.

Review 8. Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes.

9. Escherichia coli ribosomes translate in vivo with variable rate.

10. Is there proofreading during polypeptide synthesis?

1. The accuracy of codon recognition by polypeptide release factors.

2. Effect of size, quaternary structure and translational error on the static and dynamic heterogeneity of beta-galactosidase and measurement of electrophoretic dynamic heterogeneity.

Review 3. Cellular mechanisms that control mistranslation.

4. Unusual codon bias occurring within insertion sequences in Escherichia coli.

5. Evolution of codon usage bias in Drosophila.

6. Estimating selection on synonymous codon usage from noisy experimental data.

7. Engineering platforms for directed evolution of Laccase from Pycnoporus cinnabarinus.

8. The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality.

9. The signature of selection mediated by expression on human genes.

10. Functional expression of a fungal laccase in Saccharomyces cerevisiae by directed evolution.