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Literature DB >> 11836439

Enhancement of hepatitis B virus replication by its X protein in transgenic mice.

Zhenming Xu¹, T S Benedict Yen, Lanying Wu, Charles R Madden, Wenjie Tan, Betty L Slagle, Jing-hsiung Ou.

Abstract

Hepatitis B virus (HBV) X gene encodes a multifunctional protein that can regulate cellular signaling pathways, interact with cellular transcription factors, and induce hepatocellular oncogenesis. In spite of its diverse activities, the precise role of the X protein in the viral life cycle of HBV remains unclear. To investigate this question, we have produced transgenic mice that carry either the wild-type HBV genome or a mutated HBV genome incapable of expressing the 16.5-kDa X protein. Our results indicate that while the X protein is not absolutely essential for HBV replication or its maturation in transgenic mice, it can enhance viral replication, apparently by activating viral gene expression. These results demonstrate a transactivation role of the X protein in HBV replication in transgenic mice.

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Year: 2002 PMID： 11836439 PMCID： PMC153824 DOI： 10.1128/jvi.76.5.2579-2584.2002

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

39 in total

1. trans-activation of viral enhancers by the hepatitis B virus X protein.

Authors: D F Spandau; C H Lee
Journal: J Virol Date: 1988-02 Impact factor: 5.103

2. X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo.

Authors: Z Zhang; N Torii; Z Hu; J Jacob; T J Liang
Journal: J Clin Invest Date: 2001-11 Impact factor: 14.808

3. Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential.

Authors: Z Rahmani; K W Huh; R Lasher; A Siddiqui
Journal: J Virol Date: 2000-03 Impact factor: 5.103

4. Proteasome complex as a potential cellular target of hepatitis B virus X protein.

Authors: J Huang; J Kwong; E C Sun; T J Liang
Journal: J Virol Date: 1996-08 Impact factor: 5.103

5. Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5.

Authors: Y Lin; T Nomura; J Cheong; D Dorjsuren; K Iida; S Murakami
Journal: J Biol Chem Date: 1997-03-14 Impact factor: 5.157

6. Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors.

Authors: E Seto; P J Mitchell; T S Yen
Journal: Nature Date: 1990-03-01 Impact factor: 49.962

7. Control of expression and methylation of a hepatitis B virus transgene by strain-specific modifiers.

Authors: J Schweizer; P Valenza-Schaerly; F Goret; C Pourcel
Journal: DNA Cell Biol Date: 1998-05 Impact factor: 3.311

8. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.

Authors: H S Chen; S Kaneko; R Girones; R W Anderson; W E Hornbuckle; B C Tennant; P J Cote; J L Gerin; R H Purcell; R H Miller
Journal: J Virol Date: 1993-03 Impact factor: 5.103

9. Hepatitis B virus X protein is not central to the viral life cycle in vitro.

Authors: H E Blum; Z S Zhang; E Galun; F von Weizsäcker; B Garner; T J Liang; J R Wands
Journal: J Virol Date: 1992-02 Impact factor: 5.103

10. HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit.

Authors: M Fischer; L Runkel; H Schaller
Journal: Virus Genes Date: 1995 Impact factor: 2.332

54 in total

1. Viral replication modulated by synthetic peptide derived from hepatitis B virus X protein.

Authors: Chang-Zheng Song; Qing-Wei Wang; Chang-Cheng Song; Zeng-Liang Bai
Journal: World J Gastroenterol Date: 2004-02-01 Impact factor: 5.742

Review 2. The enigmatic X gene of hepatitis B virus.

Authors: Michael J Bouchard; Robert J Schneider
Journal: J Virol Date: 2004-12 Impact factor: 5.103

3. Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level.

Authors: Chi-Ming Chiu; Shiou-Hwei Yeh; Pei-Jer Chen; Ti-Jung Kuo; Ching-Ju Chang; Po-Jen Chen; Wan-Jen Yang; Ding-Shinn Chen
Journal: Proc Natl Acad Sci U S A Date: 2007-01-26 Impact factor: 11.205

4. Hepatitis B virus X protein crosses out Smc5/6 complex to maintain covalently closed circular DNA transcription.

Authors: Bidisha Mitra; Haitao Guo
Journal: Hepatology Date: 2016-10-28 Impact factor: 17.425

5. Hepatitis B virus molecular biology and pathogenesis.

Authors: R Jason Lamontagne; Sumedha Bagga; Michael J Bouchard
Journal: Hepatoma Res Date: 2016-07-01

6. Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo.

Authors: Zhensheng Zhang; Eun Sun; Jing-hsiung James Ou; T Jake Liang
Journal: J Virol Date: 2010-06-30 Impact factor: 5.103

Review 7. Technical standards for hepatitis B virus X protein (HBx) research.

Authors: Betty L Slagle; Ourania M Andrisani; Michael J Bouchard; Caroline G L Lee; J-H James Ou; Aleem Siddiqui
Journal: Hepatology Date: 2015-03-09 Impact factor: 17.425

8. Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress.

Authors: Zhi-Ming Huang; Thomas Tan; Hiderou Yoshida; Kazutoshi Mori; Yanjun Ma; T S Benedict Yen
Journal: Mol Cell Biol Date: 2005-09 Impact factor: 4.272

9. Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.

Authors: Zhensheng Zhang; Ulrike Protzer; Zongyi Hu; James Jacob; T Jake Liang
Journal: J Virol Date: 2004-05 Impact factor: 5.103

10. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein.

Authors: Yanyan Zheng; Jie Li; Jing-hsiung Ou
Journal: J Virol Date: 2004-07 Impact factor: 5.103