| Literature DB >> 29098564 |
Abstract
Hepatitis B virus is a member of the Hepadnaviridae family and responsible for causing acute and chronic hepatitis in humans. The current estimates of people chronically infected with the virus are put at 250 million worldwide. Immune-mediated liver damage in these individuals may lead to the development of cirrhosis and hepatocellular carcinoma later in life. This review deals with our current understanding of the virology, molecular biology, life cycle and cell-to-cell spread of this very important pathogen, all of which are considered essential for current and future approaches to antiviral treatment.Entities:
Keywords: Cell-to-cell spread; Genotypes; Hepatitis B virus; Life cycle; Molecular virology; Replication
Mesh:
Year: 2017 PMID: 29098564 DOI: 10.1007/s12072-017-9829-7
Source DB: PubMed Journal: Hepatol Int ISSN: 1936-0533 Impact factor: 6.047