Literature DB >> 26739780

Synthesis, structure and in vitro cytostatic activity of ferrocene-Cinchona hybrids.

László Kocsis1, Ildikó Szabó2, Szilvia Bősze2, Tamás Jernei3, Ferenc Hudecz4, Antal Csámpai5.   

Abstract

Exploring copper(I)- and ruthenium(II)-catalyzed azide-alkyne cycloadditions and a Sonogashira protocol, novel cytostatic ferrocene-cinchona hybrids were synthetized displaying significant in vitro activity on HepG-2 and HT-29 cells. Preliminary SAR studies disclosed that compounds incorporating linkers with 1,2,3-triazole and chalchone residues can be considered as promising lead structures. According to the best of our knowledge this is the first letter on the incorporation of ferrocene nucleus in the reputed cinchona family via triazole and chalcone linkers with established pharmaceutical profile.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  1,2,3-Triazole; Cinchona; Click reaction; Cytostatic activity; Ferrocene

Mesh：

Substances：

Year:  2015        PMID： 26739780     DOI： 10.1016/j.bmcl.2015.12.059

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Reactivity of (1-methoxycarbonylpentadienyl)iron(1+) cations with hydride, methyl, and nitrogen nucleophiles.

Authors:  Yuzhi Ma; Young K Yun; Julie Wondergem Nee Lukesh; Anobick Sar; Jayapal Reddy Gone; Sergey Lindeman; William A Donaldson
Journal:  Tetrahedron       Date:  2017-06-15       Impact factor: 2.457

2.  Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling.

Authors:  Ahmed Dhahir Latif; Tamás Jernei; Ana Podolski-Renić; Ching-Ying Kuo; Máté Vágvölgyi; Gábor Girst; István Zupkó; Sedef Develi; Engin Ulukaya; Hui-Chun Wang; Milica Pešić; Antal Csámpai; Attila Hunyadi
Journal:  Antioxidants (Basel)       Date:  2020-06-12

3.  Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona-Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers.

Authors:  Tamás Jernei; Cintia Duró; Antonio Dembo; Eszter Lajkó; Angéla Takács; László Kőhidai; Gitta Schlosser; Antal Csámpai
Journal:  Molecules       Date:  2019-11-11       Impact factor: 4.411

4.  Purine and Purine Isostere Derivatives of Ferrocene: An Evaluation of ADME, Antitumor and Electrochemical Properties.

Authors:  Valentina Rep; Martina Piškor; Helena Šimek; Petra Mišetić; Petra Grbčić; Jasna Padovan; Vesna Gabelica Marković; Dijana Jadreško; Krešimir Pavelić; Sandra Kraljević Pavelić; Silvana Raić-Malić
Journal:  Molecules       Date:  2020-03-29       Impact factor: 4.411

5.  Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of Their in vitro Antiproliferative Effects.

Authors:  Kinga Judit Fodor; Dániel Hutai; Tamás Jernei; Angéla Takács; Zsófia Szász; Máté Sulyok-Eiler; Veronika Harmat; Rita Oláh Szabó; Gitta Schlosser; Ferenc Hudecz; László Kőhidai; Antal Csámpai
Journal:  Molecules       Date:  2020-03-31       Impact factor: 4.411
  5 in total

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