Literature DB >> 26729504

Klebsiella pneumoniae Isolate from a New York City Hospital Belonging to Sequence Type 258 and Carrying blaKPC-2 and blaVIM-4.

Mariana Castanheira1, Lalitagauri M Deshpande2, Janet C Mills2, Ronald N Jones3, Rosemary Soave4, Stephen G Jenkins4, Audrey N Schuetz4.   

Abstract

Among 69 of 139 (49.6%) carbapenem-nonsusceptible Enterobacteriaceae carrying blaKPC, 1 Klebsiella pneumoniae was also positive for blaVIM. The isolate belonged to sequence type 258 (ST258) and carried blaKPC-2 on a copy of Tn4401a and blaVIM-4 on a class 1 integron. Genes were located on distinct plasmids belonging to Inc types A/C and FII. Elevated expression of the efflux pump AcrAB-TolC (acrA, 15.3 times) and reduced expression of outer membrane protein genes ompK35 and ompK37 (0.16 and 0.081 times, respectively) associated with various amino acid alterations on OmpK37 were observed. The presence of two carbapenemases in ST258 K. pneumoniae is of great concern due to the ability of this organism to widely disseminate.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26729504      PMCID： PMC4775970          DOI： 10.1128/AAC.01844-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

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Authors:  Constantinos C Papagiannitsis; Panagiota Giakkoupi; Alkiviadis C Vatopoulos; Kyriaki Tryfinopoulou; Vivi Miriagou; Leonidas S Tzouvelekis
Journal:  Int J Antimicrob Agents       Date:  2010-09-21       Impact factor: 5.283

2.  Emergence of Klebsiella pneumoniae Coharboring KPC and VIM Carbapenemases in Colombia.

Authors:  L J Rojas; M F Mojica; V M Blanco; A Correa; M C Montealegre; E De La Cadena; J J Maya; R D Camargo; J P Quinn; M V Villegas
Journal:  Antimicrob Agents Chemother       Date:  2012-12-10       Impact factor: 5.191

3.  A general method for detecting and sizing large plasmids.

Authors:  B M Barton; G P Harding; A J Zuccarelli
Journal:  Anal Biochem       Date:  1995-04-10       Impact factor: 3.365

4.  Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.

Authors:  H Yigit; A M Queenan; G J Anderson; A Domenech-Sanchez; J W Biddle; C D Steward; S Alberti; K Bush; F C Tenover
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

5.  Identification of plasmids by PCR-based replicon typing.

Authors:  Alessandra Carattoli; Alessia Bertini; Laura Villa; Vincenzo Falbo; Katie L Hopkins; E John Threlfall
Journal:  J Microbiol Methods       Date:  2005-06-02       Impact factor: 2.363

6.  Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011.

Authors:  J Steinmann; M Kaase; S Gatermann; W Popp; E Steinmann; M Damman; A Paul; F Saner; J Buer; Pm Rath
Journal:  Euro Surveill       Date:  2011-08-18

7.  Carbapenem-resistant Klebsiella pneumoniae harbouring blaKPC-3 and blaVIM-2 from central Italy.

Authors:  Mariagrazia Perilli; Carlo Bottoni; Alessandro Grimaldi; Bernardetta Segatore; Giuseppe Celenza; Maurizio Mariani; Pierangelo Bellio; Patrizia Frascaria; Gianfranco Amicosante
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Review 8.  Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.

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Journal:  Lancet Infect Dis       Date:  2013-09       Impact factor: 25.071

9.  Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene.

Authors:  Thierry Naas; Gaelle Cuzon; Maria-Virginia Villegas; Marie-Frédérique Lartigue; John P Quinn; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2008-01-28       Impact factor: 5.191

Review 10.  Global spread of Carbapenemase-producing Enterobacteriaceae.

Authors:  Patrice Nordmann; Thierry Naas; Laurent Poirel
Journal:  Emerg Infect Dis       Date:  2011-10       Impact factor: 6.883
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1.  Low Frequency of Ceftazidime-Avibactam Resistance among Enterobacteriaceae Isolates Carrying blaKPC Collected in U.S. Hospitals from 2012 to 2015.

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Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

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Authors:  Robert F Potter; Alaric W D'Souza; Gautam Dantas
Journal:  Drug Resist Updat       Date:  2016-09-19       Impact factor: 18.500

3.  Rapid Identification of Five Classes of Carbapenem Resistance Genes Directly from Rectal Swabs by Use of the Xpert Carba-R Assay.

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4.  Diversity of resistance mechanisms in carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016.

Authors:  Fiona Senchyna; Rajiv L Gaur; Johanna Sandlund; Cynthia Truong; Guillaume Tremintin; Dietmar Kültz; Carlos A Gomez; Fiona B Tamburini; Tessa Andermann; Ami Bhatt; Isabella Tickler; Nancy Watz; Indre Budvytiene; Gongyi Shi; Fred C Tenover; Niaz Banaei
Journal:  Diagn Microbiol Infect Dis       Date:  2018-10-13       Impact factor: 2.803

Review 5.  Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current Reports.

Authors:  Masego Mmatli; Nontombi Marylucy Mbelle; Nontuthuko E Maningi; John Osei Sekyere
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6.  CusS-CusR Two-Component System Mediates Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae.

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Journal:  Front Microbiol       Date:  2020-01-28       Impact factor: 5.640

7.  Within patient genetic diversity of blaKPC harboring Klebsiella pneumoniae in a Colombian hospital and identification of a new NTEKPC platform.

Authors:  Deisy Abril; Erika Vergara; Diana Palacios; Aura Lucía Leal; Ricaurte Alejandro Marquez-Ortiz; Johana Madroñero; Zayda Lorena Corredor Rozo; Zandra De La Rosa; Carlos A Nieto; Natasha Vanegas; Jorge A Cortés; Javier Escobar-Perez
Journal:  Sci Rep       Date:  2021-11-01       Impact factor: 4.379
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