| Literature DB >> 23153971 |
Mariagrazia Perilli1, Carlo Bottoni, Alessandro Grimaldi, Bernardetta Segatore, Giuseppe Celenza, Maurizio Mariani, Pierangelo Bellio, Patrizia Frascaria, Gianfranco Amicosante.
Abstract
The frequency of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae is increasing in Italian hospitals and poses an emerging threat to the management of infections in hospitalized patients. In this study, we report a detailed molecular characterization of a K. pneumoniae subsp. pneumoniae KP1/11 isolate from the decubitus ulcer of a hospitalized patient with a serious infection. K. pneumoniae KP1/11 produces KPC-3 and VIM-2 β-lactamases. The bla(KPC-3) gene is harbored in a large plasmid in a complex structure of Tn3-based transposon, Tn4401a. The chromosomal DNA of K. pneumoniae harbored also 2 class 1 integrons with different variable regions: 1) orfD-aacA8; 2) aacA29-bla(VIM-2).Entities:
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Year: 2012 PMID： 23153971 DOI： 10.1016/j.diagmicrobio.2012.10.008
Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803