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Literature DB >> 26724389

Precision Medicine: Clarity for the Complexity of Dementia.

Brenna Cholerton¹, Eric B Larson², Joseph F Quinn³, Cyrus P Zabetian⁴, Ignacio F Mata⁵, C Dirk Keene⁶, Margaret Flanagan⁶, Paul K Crane⁷, Thomas J Grabowski⁸, Kathleen S Montine⁶, Thomas J Montine⁹.

Abstract

Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

Entities: Disease

Mesh：

Year: 2015 PMID： 26724389 PMCID： PMC4816691 DOI： 10.1016/j.ajpath.2015.12.001

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

56 in total

1. Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom.

Authors: Peter Hobson; Jolyon Meara
Journal: Mov Disord Date: 2004-09 Impact factor: 10.338

2. GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.

Authors: Ignacio F Mata; James B Leverenz; Daniel Weintraub; John Q Trojanowski; Alice Chen-Plotkin; Vivianna M Van Deerlin; Beate Ritz; Rebecca Rausch; Stewart A Factor; Cathy Wood-Siverio; Joseph F Quinn; Kathryn A Chung; Amie L Peterson-Hiller; Jennifer G Goldman; Glenn T Stebbins; Bryan Bernard; Alberto J Espay; Fredy J Revilla; Johnna Devoto; Liana S Rosenthal; Ted M Dawson; Marilyn S Albert; Debby Tsuang; Haley Huston; Dora Yearout; Shu-Ching Hu; Brenna A Cholerton; Thomas J Montine; Karen L Edwards; Cyrus P Zabetian
Journal: Mov Disord Date: 2015-08-21 Impact factor: 10.338

3. Cohort profile: Epidemiological Clinicopathological studies in Europe (EClipSE).

Authors:
Journal: J Alzheimers Dis Date: 2009 Impact factor: 4.472

4. Ecology of the aging human brain.

Authors: Joshua A Sonnen; Karen Santa Cruz; Laura S Hemmy; Randall Woltjer; James B Leverenz; Kathleen S Montine; Clifford R Jack; Jeffrey Kaye; Kelvin Lim; Eric B Larson; Lon White; Thomas J Montine
Journal: Arch Neurol Date: 2011-08

5. Effect of common neuropathologies on progression of late life cognitive impairment.

Authors: Lei Yu; Patricia A Boyle; Sue Leurgans; Julie A Schneider; Richard J Kryscio; Robert S Wilson; David A Bennett
Journal: Neurobiol Aging Date: 2015-04-22 Impact factor: 4.673

Review 6. Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments.

Authors: Eric M Reiman; Jessica B S Langbaum; Adam S Fleisher; Richard J Caselli; Kewei Chen; Napatkamon Ayutyanont; Yakeel T Quiroz; Kenneth S Kosik; Francisco Lopera; Pierre N Tariot
Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472

7. Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.

Authors: Nadia Postupna; Christopher Dirk Keene; Paul K Crane; Luis F Gonzalez-Cuyar; Joshua A Sonnen; Jessica Hewitt; Samantha Rice; Kimberly Howard; Kathleen S Montine; Eric B Larson; Thomas J Montine
Journal: J Neuropathol Exp Neurol Date: 2015-02 Impact factor: 3.685

Review 8. The Parkinson Progression Marker Initiative (PPMI).

Authors:
Journal: Prog Neurobiol Date: 2011-09-14 Impact factor: 10.885

Review 9. Recommendations of the Alzheimer's disease-related dementias conference.

Authors: Thomas J Montine; Walter J Koroshetz; Debra Babcock; Dennis W Dickson; Wendy R Galpern; M Maria Glymour; Steven M Greenberg; Michael L Hutton; David S Knopman; Andrey N Kuzmichev; Jennifer J Manly; Karen S Marder; Bruce L Miller; Creighton H Phelps; William W Seeley; Beth-Anne Sieber; Nina B Silverberg; Margaret Sutherland; Christine L Torborg; Salina P Waddy; Berislav V Zlokovic; Roderick A Corriveau
Journal: Neurology Date: 2014-07-30 Impact factor: 9.910

Review 10. Neurobiology of Alzheimer's Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions.

Authors: Joel Raskin; Jeffrey Cummings; John Hardy; Kory Schuh; Robert A Dean
Journal: Curr Alzheimer Res Date: 2015 Impact factor: 3.498

14 in total

1. Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson's disease.

Authors: Krista Specketer; Cyrus P Zabetian; Karen L Edwards; Lu Tian; Joseph F Quinn; Amie L Peterson-Hiller; Kathryn A Chung; Shu-Ching Hu; Thomas J Montine; Brenna A Cholerton
Journal: J Clin Exp Neuropsychol Date: 2019-06-10 Impact factor: 2.475

Review 2. Precision medicine for disease modification in Parkinson disease.

Authors: Alberto J Espay; Patrik Brundin; Anthony E Lang
Journal: Nat Rev Neurol Date: 2017-01-20 Impact factor: 42.937

3. PRECISION MEDICINE - The Golden Gate for Detection, Treatment and Prevention of Alzheimer's Disease.

Authors: H Hampel; S E O'Bryant; J I Castrillo; C Ritchie; K Rojkova; K Broich; N Benda; R Nisticò; R A Frank; B Dubois; V Escott-Price; S Lista
Journal: J Prev Alzheimers Dis Date: 2016-09-06

4. Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study.

Authors: Paul K Crane; Emily Trittschuh; Shubhabrata Mukherjee; Andrew J Saykin; R Elizabeth Sanders; Eric B Larson; Susan M McCurry; Wayne McCormick; James D Bowen; Thomas Grabowski; Mackenzie Moore; Julianna Bauman; Alden L Gross; C Dirk Keene; Thomas D Bird; Laura E Gibbons; Jesse Mez
Journal: Alzheimers Dement Date: 2017-06-15 Impact factor: 21.566

5. Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4.

Authors: Nadia Postupna; Caitlin S Latimer; Eric B Larson; Emily Sherfield; Julie Paladin; Carol A Shively; Matthew J Jorgensen; Rachel N Andrews; Jay R Kaplan; Paul K Crane; Kathleen S Montine; Suzanne Craft; C Dirk Keene; Thomas J Montine
Journal: Am J Pathol Date: 2017-02-16 Impact factor: 4.307