Literature DB >> 26719440

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam-β-Lactamase Inhibitor Combinations.

Gina K Thomson1, James W Snyder2, Christi L McElheny3, Kenneth S Thomson2, Yohei Doi4.   

Abstract

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, bla(KPC-18) and bla(VIM-1). Whole-genome sequencing localized bla(KPC-18) to the chromosome and bla(VIM-1) to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam-β-lactamase inhibitor combinations.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26719440      PMCID： PMC4767958          DOI： 10.1128/JCM.02739-15

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  22 in total

1.  Sequence of pNL194, a 79.3-kilobase IncN plasmid carrying the blaVIM-1 metallo-beta-lactamase gene in Klebsiella pneumoniae.

Authors:  V Miriagou; C C Papagiannitsis; S D Kotsakis; A Loli; E Tzelepi; N J Legakis; L S Tzouvelekis
Journal:  Antimicrob Agents Chemother       Date:  2010-07-26       Impact factor: 5.191

2.  First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.

Authors:  K Lolans; A M Queenan; K Bush; A Sahud; J P Quinn
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

3.  Activity of temocillin against KPC-producing Klebsiella pneumoniae and Escherichia coli.

Authors:  Jennifer M Adams-Haduch; Brian A Potoski; Hanna E Sidjabat; David L Paterson; Yohei Doi
Journal:  Antimicrob Agents Chemother       Date:  2009-03-30       Impact factor: 5.191

4.  Emergence of Klebsiella pneumoniae carrying bla(VIM) and bla(KPC) genes.

Authors:  G Meletis; E Tzampaz; E Protonotariou; D Sofianou
Journal:  Hippokratia       Date:  2010-04       Impact factor: 0.471

5.  Outbreak due to a Klebsiella pneumoniae strain harbouring KPC-2 and VIM-1 in a German university hospital, July 2010 to January 2011.

Authors:  J Steinmann; M Kaase; S Gatermann; W Popp; E Steinmann; M Damman; A Paul; F Saner; J Buer; Pm Rath
Journal:  Euro Surveill       Date:  2011-08-18

6.  Emergence of a multiresistant KPC-3 and VIM-1 carbapenemase-producing Escherichia coli strain in Spain.

Authors:  Nerea Porres-Osante; Jose Manuel Azcona-Gutiérrez; Beatriz Rojo-Bezares; Esther Undabeitia; Carmen Torres; Yolanda Sáenz
Journal:  J Antimicrob Chemother       Date:  2014-02-28       Impact factor: 5.790

7.  MLST reveals potentially high-risk international clones of Enterobacter cloacae.

Authors:  R Izdebski; A Baraniak; M Herda; J Fiett; M J M Bonten; Y Carmeli; H Goossens; W Hryniewicz; C Brun-Buisson; M Gniadkowski
Journal:  J Antimicrob Chemother       Date:  2014-09-12       Impact factor: 5.790

8.  Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa.

Authors:  Krystyna M Kazmierczak; Sharon Rabine; Meredith Hackel; Robert E McLaughlin; Douglas J Biedenbach; Samuel K Bouchillon; Daniel F Sahm; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2015-12-07       Impact factor: 5.191

Review 9.  Treating infections caused by carbapenemase-producing Enterobacteriaceae.

Authors:  L S Tzouvelekis; A Markogiannakis; E Piperaki; M Souli; G L Daikos
Journal:  Clin Microbiol Infect       Date:  2014-07-12       Impact factor: 8.067

Review 10.  New β-lactamase inhibitors: a therapeutic renaissance in an MDR world.

Authors:  Sarah M Drawz; Krisztina M Papp-Wallace; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2013-12-30       Impact factor: 5.191
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  5 in total

Review 1.  Recognizing and Overcoming Resistance to New Beta-Lactam/Beta-Lactamase Inhibitor Combinations.

Authors:  Stephanie Ho; Lynn Nguyen; Trang Trinh; Conan MacDougall
Journal:  Curr Infect Dis Rep       Date:  2019-09-09       Impact factor: 3.725

Review 2.  The rapid spread of carbapenem-resistant Enterobacteriaceae.

Authors:  Robert F Potter; Alaric W D'Souza; Gautam Dantas
Journal:  Drug Resist Updat       Date:  2016-09-19       Impact factor: 18.500

3.  Chromosomal 16S Ribosomal RNA Methyltransferase RmtE1 in Escherichia coli Sequence Type 448.

Authors:  Bin Li; Marissa P Pacey; Yohei Doi
Journal:  Emerg Infect Dis       Date:  2017-05       Impact factor: 6.883

4.  High-Stringency Evaluation of the Automated BD Phoenix CPO Detect and Rapidec Carba NP Tests for Detection and Classification of Carbapenemases.

Authors:  Gina Thomson; David Turner; William Brasso; Susan Kircher; Thierry Guillet; Kenneth Thomson
Journal:  J Clin Microbiol       Date:  2017-10-04       Impact factor: 5.948

5.  Further Spread of a blaKPC-Harboring Untypeable Plasmid in Enterobacteriaceae in China.

Authors:  Jiansheng Huang; Hui Ding; Yang Shi; Yunan Zhao; Xiaolei Hu; Jianmin Ren; Guiying Huang; Rongzhen Wu; Zhigang Zhao
Journal:  Front Microbiol       Date:  2018-08-21       Impact factor: 5.640
  5 in total

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