Nico Steckhan1, Christoph-Daniel Hohmann2, Christian Kessler2, Gustav Dobos3, Andreas Michalsen2, Holger Cramer3. 1. Institute of Social Medicine, Epidemiology and Health Economics, Charité-University Medical Centre, Berlin, Germany and Immanuel Hospital Berlin; Immanuel Hospital Berlin, Department of Internal and Complementary Medicine, Berlin, Germany. Electronic address: nico.steckhan@charite.de. 2. Institute of Social Medicine, Epidemiology and Health Economics, Charité-University Medical Centre, Berlin, Germany and Immanuel Hospital Berlin; Immanuel Hospital Berlin, Department of Internal and Complementary Medicine, Berlin, Germany. 3. Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Abstract
OBJECTIVE: Chronic low-grade inflammation has been associated with insulin resistance, diabetes, atherosclerosis, obesity, and metabolic syndrome (MetS). A proinflammatory environment contributes to several metabolic disturbances and possibly the development of MetS. Dietary approaches have defined impact on immune function and putative antiinflammatory effects. The aim of this study was to assess the effects of different dietary approaches on markers of inflammation in patients with MetS. Further effects on weight loss and fasting insulin were analyzed. METHODS: Medline/PubMed, Scopus, and the Cochrane Library were screened in September 2014 for randomized controlled trials (RCTs) on different dietary approaches for participants with MetS as defined by National Cholesterol Education Program Adult Treatment Panel III. Primary outcomes were markers of the immune system. Secondary outcome was body weight and fasting insulin. Standardized mean differences (SMD) and 95% confidence intervals (95% CIs) were calculated. RESULTS: Thirteen randomized controlled trials with a total of 2017 patients were included. Low-fat diets (29 ± 2% energy from fats) decreased C-reactive protein compared with control diets (SMD: -0.98; 95% CI: -1.6 to -0.35; P = 0.002). Low-carbohydrate diets (23 ± 10% energy from carbohydrates; SMD: -0.33; 95% CI: -0.63 to -0.03; P = 0.004) and multimodal interventions (SMD: -1.02; 95% CI: -1.97 to -0.07; P = 0.04) were able to induce significant weight loss. Low-carbohydrate diets were able to decrease insulin (SMD: -0.33; 95% CI: -0.63 to -0.03; P = 0.03). CONCLUSIONS: C-reactive protein; however, this effect is also dependent on weight loss. Furthermore, low-carbohydrate diets have beneficial effects on insulin and body weight. Dietary approaches should mainly be tried to reduce macronutrients and enrich functional food components such as vitamins, flavonoids, and unsaturated fatty acids. People with MetS will benefit most by combining weight loss and anti-inflammatory nutrients.
OBJECTIVE: Chronic low-grade inflammation has been associated with insulin resistance, diabetes, atherosclerosis, obesity, and metabolic syndrome (MetS). A proinflammatory environment contributes to several metabolic disturbances and possibly the development of MetS. Dietary approaches have defined impact on immune function and putative antiinflammatory effects. The aim of this study was to assess the effects of different dietary approaches on markers of inflammation in patients with MetS. Further effects on weight loss and fasting insulin were analyzed. METHODS: Medline/PubMed, Scopus, and the Cochrane Library were screened in September 2014 for randomized controlled trials (RCTs) on different dietary approaches for participants with MetS as defined by National Cholesterol Education Program Adult Treatment Panel III. Primary outcomes were markers of the immune system. Secondary outcome was body weight and fasting insulin. Standardized mean differences (SMD) and 95% confidence intervals (95% CIs) were calculated. RESULTS: Thirteen randomized controlled trials with a total of 2017 patients were included. Low-fat diets (29 ± 2% energy from fats) decreased C-reactive protein compared with control diets (SMD: -0.98; 95% CI: -1.6 to -0.35; P = 0.002). Low-carbohydrate diets (23 ± 10% energy from carbohydrates; SMD: -0.33; 95% CI: -0.63 to -0.03; P = 0.004) and multimodal interventions (SMD: -1.02; 95% CI: -1.97 to -0.07; P = 0.04) were able to induce significant weight loss. Low-carbohydrate diets were able to decrease insulin (SMD: -0.33; 95% CI: -0.63 to -0.03; P = 0.03). CONCLUSIONS:C-reactive protein; however, this effect is also dependent on weight loss. Furthermore, low-carbohydrate diets have beneficial effects on insulin and body weight. Dietary approaches should mainly be tried to reduce macronutrients and enrich functional food components such as vitamins, flavonoids, and unsaturated fatty acids. People with MetS will benefit most by combining weight loss and anti-inflammatory nutrients.
Authors: Stephen F Smagula; Mary L Biggs; Mini E Jacob; Andreea M Rawlings; Michelle C Odden; Alice Arnold; Anne B Newman; Daniel J Buysse Journal: Psychosom Med Date: 2022-06-28 Impact factor: 3.864
Authors: Brian F Zamarron; Cara E Porsche; Danny Luan; Hannah R Lucas; Taleen A Mergian; Gabriel Martinez-Santibanez; Kae Won Cho; Jennifer L DelProposto; Lynn M Geletka; Lindsey A Muir; Kanakadurga Singer; Carey N Lumeng Journal: Obesity (Silver Spring) Date: 2020-04-13 Impact factor: 5.002
Authors: James A Blumenthal; Patrick J Smith; Stephanie Mabe; Alan Hinderliter; Kathleen Welsh-Bohmer; Jeffrey N Browndyke; Pao-Hwa Lin; William Kraus; P Murali Doraiswamy; James Burke; Andrew Sherwood Journal: Psychosom Med Date: 2017 Jul/Aug Impact factor: 4.312
Authors: Brian F Zamarron; Taleen A Mergian; Kae Won Cho; Gabriel Martinez-Santibanez; Danny Luan; Kanakadurga Singer; Jennifer L DelProposto; Lynn M Geletka; Lindsey A Muir; Carey N Lumeng Journal: Diabetes Date: 2016-11-08 Impact factor: 9.461